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Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

medicalxpress.com

251–260 of 394 posts

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#251
post #223

Earlier quoted context omitted.

A single protein shake typically provides around 22g of protein, which is a small portion of the recommended daily intake for maintaining muscle, generally close to 1g of protein per pound of body weight. As an example, I'm currently on a weight loss diet and have a 180g of proteins target per day. Unless you were significantly under-consuming protein, it's unlikely that the shake alone made a major difference.

Such high recommendations are for people that want to maximize muscle retention / growth not people that just want to be healthy. You can get by on much less.

But strength training is required anyone who wants to be healthy [0]. The RDA is just for avoiding clinical deficiency.

[0] https://www.barbellmedicine.com/blog/where-should-my-priorit...

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#252
post #71

Earlier quoted context omitted.

Regex is one of my favorite things to work with. It's surgery. I love having a very specific problem and a very sharp knife. What I hate is chasing down language or library bugs, or undocumented limitations. Of course I would hate it if I had never used it extensively. Its terseness is harder if you only have to pick it up occasionally.

Yes, once you have a scalpel, everything looks like a very specific problem ;)

That is the temptation! No requirements, no conventions, no best practices, no nagging boss, just me and total root access to all the files :)

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#253
post #92

Earlier quoted context omitted.

As far as I know, muscle is only used when fat reserves are depleted or you don't eat enough protein for the brain's personal amino acid supply. I'm not particularly knowledgeable about this, though, maybe an expert can weigh in.

Any calorie deficit of 500 under BMR and the body will not just consume the fat stores but also muscle. That’s what I learned on the bodybuilding forums at least. Some people went too high on the deficit and ended up losing some muscle definition

It's more likely to happen if your deficit below TDEE is greater than 500 Calories. If you're 500 below BMR, you're almost definitionally losing weight at an unsustainably unhealthy rate, like much greater than 1% of your bodyweight lost per week.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#254
post #87

Earlier quoted context omitted.

Remember to get a license for your code https://regexlicensing.org/

> Licenses: “No regex licenses have been issued at this time.” Perfect

Just license 007: License to kill.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#255

Earlier quoted context omitted.

Caffeine is grandfathered in as a Generally Recognized as Safe food additive. If energy drink companies had to go through clinical trials with no patent protection for each drink formula, they wouldn't make them.

Why was caffeine studied? Why does it continue to be studied?

It’s a lot cheaper to study something in academia than to do a full clinical trial.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#256
post #3

If this really has the potential to compete with Ozempic, then it should have a noticeable impact on Novo Nordisk's stock value [1], but we're not seeing that yet. [1] https://finance.yahoo.com/quote/NVO/

This assumes that NN won't snap it up themselves.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#257
post #188

This is the press release that is being republished with ads in the post link https://med.stanford.edu/news/all-news/2025/03/ozempic-rival...

https://www.nature.com/articles/s41586-025-08683-y

This seems to be the paper, but its behind a paywall.

Anyone with access can tell me if they publish the 12mer amino acid sequence? Is there more to it (post translational modifications)

Or is it just the peptide?

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#258
post #237
post #7

Delighted to discover this kind of breakthrough is based on a gnarly regular expression: https://github.com/Svensson-Lab/pro-hormone-predictor/blob/m...

Obligatory xkcd: https://xkcd.com/208/

A very early one at that

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#259
post #185

Since it is naturally occurring, it isn't patentable. Which means it is less likely that companies will develop a commercial product from it. Why pay to get FDA approval, if you don't get a government granted monopoly on it afterwards? This is one problem with using patents as the mechanism to incentivise development of medicine.

I've always been very, very skeptical of this claim. If there's an actual natural, identified substance with huge benefits to people, it's going to go gangbusters and you're going to make a lot, LOT of money selling it, even if you're doing it via roadside lemonade stand. It feels like this claim is usually used to promote cures and treatments with extremely low quality RCTs backing their use as a sort of panacea. I…

Lithium is a good counter. It is by far the best treatment for bipolar 1, and its cheap and easy to source. Prices for lithium carbonate and other lithium medicament's are not at all cheap, and there are not a lot of medical companies producing it. There has even been shortages. Instead antipsychotics have been pushed as a preferred treatment, even though the outcomes are worse than with lithium.

Re: Natural occurring molecule rivals Ozempic in weight loss, sidesteps side effects

#260
post #168

Earlier quoted context omitted.

interesting TIL too bad we don't have auto doc gen (fastapi what I'm working with atm) edit: not saying it can't be done but our org isn't using auto docs

Yeah, it's one of those "Once you're used to writing doc strings, you have no reason to ever use anything else" but if you don't use them, it can be prohibitively laborious to move whatever alternative you're using over to "PEP-compliant". ( lots of fun dunder functions in Python that make metaprogramming a lot easier, but someone needs to tell you about)

Fluent Python covers a bunch of this stuff.
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