Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

GLP-1 drugs: An economic disruptor? (2024)

wildfirelabs.substack.com

Post reply on HN
Print view View original

421–430 of 553 posts

Re: GLP-1 drugs: An economic disruptor? (2024)

#421

Post by dang »

Judgmentality wrote: post #316
dang wrote: post #287

Earlier quoted context omitted.

Your comments come across as more aggressive than perhaps you intend them to. We've had to ask you similar things before. Telling someone that their spending is "fucking egregious" and "who knows what else you didn't mention", would land with most people as quite a provocation. The fact that cj replied courteously says something good about cj, but your comment broke the site guidelines and we need you not to do that.…

You're right. I was being a dick.

I wouldn't put it that way but I respect and appreciate the reply.

Re: GLP-1 drugs: An economic disruptor? (2024)

#422

Post by llm_trw »

raphman wrote: post #253

Is this person an expert of any kind? They throw around dozens of numbers without any sources. For example, > 'A movie theater chain recently analyzed their user data and discovered that 72% of their profits came from concessions, primarily from impulse purchases made by people who swore they "wouldn't buy anything."' This combination of non-descript source, precise numbers, and 'quotes' looks like the usual bullshit…

Is there any evidence for general impulse control?

I'm seeing papers claiming both increased and decreased impulse control.

Re: GLP-1 drugs: An economic disruptor? (2024)

#423

Post by andbberger »

appleorchard46 wrote: post #334

Obesity causes many health problems, but it's also a symptom - of our poor relationship with food, of the way American society is set up around instant gratification, of the predatory nature of food manufacturers. Though treating the symptom is undeniably good, it also lets the deeper problems that lead to it go unchecked, and my fear is that it will lead to novel problems down the line. How recreational drugs are be…

name some nations that maintain healthy weight without drugs? your dogma isn't supported by the data. obesity is a public health problem and it's not caused simply by junk food

Re: GLP-1 drugs: An economic disruptor? (2024)

#424

Post by ChiperSoft »

maleldil wrote: post #289
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

> being overweight will be a choice Not everyone can take these drugs. Some people will have severe side effects. It's very common to have nausea, vomiting, etc., and some people will experience these frequently enough that the prescribing doctor will rescind the prescription.

This was me. I’ve been on them for four years and actually gained fifty pounds

The drug keeps me from binge eating, which is huge, but if I take enough to actually lose weight then I have weekly bouts of food poisoning because the sugars in my gut start to ferment. An entire day sitting on the toilet while holding a bucket because it’s coming out both ends.

Re: GLP-1 drugs: An economic disruptor? (2024)

#426

Post by glp1guide »

jijji wrote: post #394
glp1guide wrote: post #339

Earlier quoted context omitted.

Yeah unfortunately that’s about to come to an abrupt end

how so? the last i checked, the prices are going down, not up (from the biolabs that manufacture the peptides)

Sorry a bit late here, but both Tirzepatide and Semaglutide are off the shortage list, and the promise to not seek legal action that is currently allowing some compounders to operate freely will likely end sometime soon.

Literally, the only reason any compounder today (that is brave enough) can produce Tirzepatide or Semaglutide is because the FDA has promised to not pursue legal action for a short period to enable people to find other solutions.

Prices are about to go back up/a bunch of options are about to leave the market. See: Novo Nordisk's share price/related news.

Re: GLP-1 drugs: An economic disruptor? (2024)

#427

Post by glp1guide »

glp1guide wrote: post #337

Incredibly excited about these drugs (like everyone else) and have been looking into them for a bit. A few notes: - Semaglutide just came off the shortage list [0], companies won’t be able to compound it for long - generic Liraglutide exists, and is about half as effective - patent expiries vary[1] [0]: https://glp1.guide/content/semaglutide-removed-from-shortage... [1]: https://glp1.guide/content/another-generic-lir…

Woops, last link is wrong:

https://glp1.guide/content/patent-expirations-for-glp1-recep...

Re: GLP-1 drugs: An economic disruptor? (2024)

#428

Post by monitron »

p0w3n3d wrote: post #32

Don't those drugs have serious side effects? I remember reading something but not sure where

Some people experience major side effects. Neither my wife (semaglutide) nor I (tirzepatide) have had any negative effects apart from minor upper GI disturbances when moving up to a higher dose. These dissipate within a week or so.

That said, these are definitely serious drugs and I wouldn't be taking one if my quality and length of life weren't threatened by metabolic syndrome, and if I hadn't been trying for decades to solve the problem without medication.

Re: GLP-1 drugs: An economic disruptor? (2024)

#429

Post by llm_trw »

brokensegue wrote: post #26
aljgz wrote: post #14

> When companies like Google see their healthcare costs drop by $12,000 per employee annually and productivity increase by 25%, we observe a restructuring of corporate America that makes remote work a minor adjustment. In my entire office, there's one overweight person that I know. Out of thousands of employees. There could be more, and other cities might be different, but you get the idea. The author intentionally o…

40% of Americans are obese and way more are merely overweight. Either your office is small, a huge fluke, weirdly selected or you're not observant enough.

The 40% of Americans who are obese don't work at Google.

Re: GLP-1 drugs: An economic disruptor? (2024)

#430

Post by llm_trw »

bgnn wrote: post #201
brokensegue wrote: post #26

Earlier quoted context omitted.

40% of Americans are obese and way more are merely overweight. Either your office is small, a huge fluke, weirdly selected or you're not observant enough.

Luckily there's the rest of the world.

The rest of the world is just 30 years behind the Us.

The Netherlands today are fatter than Missisipi was in 1985.

Post reply on HN