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Accelerating scientific breakthroughs with an AI co-scientist

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Re: Accelerating scientific breakthroughs with an AI co-scientist

#11
I'm not sure if people here even read the entirety of the article. From the article:

> We applied the AI co-scientist to assist with the prediction of drug repurposing opportunities and, with our partners, validated predictions through computational biology, expert clinician feedback, and in vitro experiments.

> Notably, the AI co-scientist proposed novel repurposing candidates for acute myeloid leukemia (AML). Subsequent experiments validated these proposals, confirming that the suggested drugs inhibit tumor viability at clinically relevant concentrations in multiple AML cell lines.

and,

> For this test, expert researchers instructed the AI co-scientist to explore a topic that had already been subject to novel discovery in their group, but had not yet been revealed in the public domain, namely, to explain how capsid-forming phage-inducible chromosomal islands (cf-PICIs) exist across multiple bacterial species. The AI co-scientist system independently proposed that cf-PICIs interact with diverse phage tails to expand their host range. This in silico discovery, which had been experimentally validated in the original novel laboratory experiments performed prior to use of the AI co-scientist system, are described in co-timed manuscripts (1, 2) with our collaborators at the Fleming Initiative and Imperial College London. This illustrates the value of the AI co-scientist system as an assistive technology, as it was able to leverage decades of research comprising all prior open access literature on this topic.

The model was able to come up with new scientific hypotheses that were tested to be correct in the lab, which is quite significant.

Re: Accelerating scientific breakthroughs with an AI co-scientist

#13
It seems in general we’re heading toward’s Minsky’s society of minds concept. I know OpenAI is wanting to collapse all their models into a single omni model that can do it all, but I wonder if under the hood it’d just be about routing. It’d make sense to me for agents to specialize in certain tool calls, ways of thinking, etc that as a conceptual framework/scaffolding provides a useful direction.

Re: Accelerating scientific breakthroughs with an AI co-scientist

#16
post #9
post #6

Earlier quoted context omitted.

> I don’t need an ai to connect across ideas or come up with new hypothesis. This feels like hubris to me. The idea here isn't to assist you with menial tasks, the idea is to give you an AI generalist that might ne able to alert you to things outside of your field that may be related to your work. It's not going to reduce your workload, in fact, it'll probably increase it but the result should be better science. I ha…

Are you a scientist?

It is obvious that scientists are afraid for their job, that mere lab technicians will now be sufficient.

Re: Accelerating scientific breakthroughs with an AI co-scientist

#17

I'm not sure if people here even read the entirety of the article. From the article: > We applied the AI co-scientist to assist with the prediction of drug repurposing opportunities and, with our partners, validated predictions through computational biology, expert clinician feedback, and in vitro experiments. > Notably, the AI co-scientist proposed novel repurposing candidates for acute myeloid leukemia (AML). Subse…

This is one thing I've been wondering about AI: will its broad training enable it to uncover previously covered connections between areas the way multi-disciplinary people tend to, or will it still miss them because it's still limited to its training corpus and can't really infer.

If it ends up being more the case that AI can help us discover new stuff, that's very optimistic.

Re: Accelerating scientific breakthroughs with an AI co-scientist

#18

Tbh I don’t see why I would use this. I don’t need an ai to connect across ideas or come up with new hypothesis. I need it to write lots of data pipeline code to take data that is organized by project, each in a unique way, each with its own set of multimodal data plus metadata all stored in long form documents with no regular formatting, and normalize it all into a giant database. I need it to write and test a data…

The doing tends to be the hard part. Every scientist has 1000 idea for every one they get a chance to pursue. That said, I requested early access.

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Re: Accelerating scientific breakthroughs with an AI co-scientist

#19

I'm not sure if people here even read the entirety of the article. From the article: > We applied the AI co-scientist to assist with the prediction of drug repurposing opportunities and, with our partners, validated predictions through computational biology, expert clinician feedback, and in vitro experiments. > Notably, the AI co-scientist proposed novel repurposing candidates for acute myeloid leukemia (AML). Subse…

Not that I don't think there's a lot of potential in this approach, but the leukemia example seemed at least poorly-worded, "the suggested drugs inhibit tumor viability" reads oddly given that blood cancers don't form tumors?

Re: Accelerating scientific breakthroughs with an AI co-scientist

#20
“Drug repurposing for AML” lol

As a person who is literally doing his PhD on AML by implementing molecular subtyping, and ex-vivo drug predictions. I find this super random.

I would truly suggest our pipeline instead of random drug repurposing :)

https://celvox.co/solutions/seAMLess

edit: Btw we’re looking for ways to fund/commercialize our pipeline. You could contact us through the site if you’re interested!

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