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Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

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Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#81

Earlier quoted context omitted.

Autism plus "AI for social" coprocessor could be a wicked combo ;)

I know several autistic adults who check their outgoing messages with AI for unintentional meanings or recommendations to better communicate what they mean. Not getting the ai to write for them mind you. Social coprocessor indeed!

Do you have details? What prompts and what models?

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#82
post #12
post #2

What if growing bigger, more connected brains is the next evolutionary step? Doesn't seem entirely unreasonable to me.

This is like assuming that cancer is good? More cells, better body? This is just a hypothetical counter-argument. More connectivity could be better, "more intelligent", and autism seems to be "cool" among nerds for this reason. But maybe it's just a fallacy, just a way to pretend to be something better. Again, all hypothetical. Yesterday I listened to a podcast episode about bird brains [0]. That some birds have a wa…

yeah sure my autism is real cool and all until I forget my sunglasses or my headphones die at the grocery store. cool or uncool aside, seems like life must feel considerably more comfortable than for those of us with all the senses cranked to 100 24/7.

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#83
post #66

Earlier quoted context omitted.

I think I've made the case above that it's not merely about "being neurotypical", it's also about being steeped in a very specific culture. That peculiar use of "why did you apply" might as well be described as an idiomatic expression, a play on words that happens to be common in that well-defined context. If you aren't familiar with that usage because you are from a different cultural context (or even something as s…

My point isn't that neurotypical people will always be familiar with whatever idioms they encounter, but that learning those idioms is way easier for them. It seems like you're misunderstanding what I'm saying as the struggles of not understanding specific things as being specific to autistic people, and that's not the case; I'm saying that while neurotypical people might have to deal with specific cases of idioms or…

As someone having experienced (and of course still experiencing) similar struggles as a person with ADHD, the Heureka moment for me was realizing that the difference is I'm overthinking it. In quite a lot of the situations, there's no right answer people are looking for. There's no strict protocol, people just say whatever random stuff that comes into their mind and it might not even be related to what the other person said, then the other person builds on from there or says their own random stuff. Sometimes they strike a chord, sometimes they don't. Sometimes they end up saying the completely wrong thing and then they may or may not attempt to correct the situation. Trying to attribute a system to it is mostly just my own desire for order that probably doesn't exist. Like most things in life, the system is so complex that it might as well be random in some aspects.

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#84
post #69

I am not an expert in any way, shape or form but I wonder how this squares with this other journal article in Nature: Molecular Psychiatry which came out in 2024? "11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults" https://doi.org/10.1038/s41380-024-02776-2 Edited to add title of the article

Wouldn't be the first time that a syndrome ends up having basically two opposite etiologies.

Abnormal synaptic density-- high or low) producing autism-like social deficits wouldn't be too much of a surprise.

Alternatively, starting with high connectivity resulting in a greater rate of synaptic pruning and overcorrection wouldn't be a surprise, either.

All are interesting things to think about and watch evolve.

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#85
post #66

Earlier quoted context omitted.

My point isn't that neurotypical people will always be familiar with whatever idioms they encounter, but that learning those idioms is way easier for them. It seems like you're misunderstanding what I'm saying as the struggles of not understanding specific things as being specific to autistic people, and that's not the case; I'm saying that while neurotypical people might have to deal with specific cases of idioms or…

As someone having experienced (and of course still experiencing) similar struggles as a person with ADHD, the Heureka moment for me was realizing that the difference is I'm overthinking it. In quite a lot of the situations, there's no right answer people are looking for. There's no strict protocol, people just say whatever random stuff that comes into their mind and it might not even be related to what the other pers…

"Overthinking" stuff is good for you actually. It's just a phase of learning any sort of skill: 1. Unconscious incompetence 2. Conscious incompetence 3. Conscious competence 4. Unconscious competence. Step 4 is where you get rid of the "overthinking" bit.

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#86
post #69

I am not an expert in any way, shape or form but I wonder how this squares with this other journal article in Nature: Molecular Psychiatry which came out in 2024? "11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults" https://doi.org/10.1038/s41380-024-02776-2 Edited to add title of the article

OP's article is about children, yours is about adults.

OP's article's conclusion states "Furthermore, our study highlights the importance of studying neurodevelopmental disorders closer to their onset, rather than in adulthood when a lifetime of compensatory mechanisms may have already taken place"

As I understand, autistic people often get negative reinforcement from authoritarian mindsets of society (follow the general norm and the power structures instead of thinking for yourself) and that can be kinda traumatizing for autistic people

So what we need is to value that every person's perspective is equally valid, and their ideas are plausible, and no one is inherently superior, whether NT or ASD etc...

> Regard man as a mine rich in gems of inestimable value > > -Baha'i Teaching

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#87

Earlier quoted context omitted.

As someone having experienced (and of course still experiencing) similar struggles as a person with ADHD, the Heureka moment for me was realizing that the difference is I'm overthinking it. In quite a lot of the situations, there's no right answer people are looking for. There's no strict protocol, people just say whatever random stuff that comes into their mind and it might not even be related to what the other pers…

"Overthinking" stuff is good for you actually. It's just a phase of learning any sort of skill: 1. Unconscious incompetence 2. Conscious incompetence 3. Conscious competence 4. Unconscious competence. Step 4 is where you get rid of the "overthinking" bit.

For sure, zero disagreement there! Just pointing out my personal observation that most people seem to not really do that.

In myself, overthinking is a quality I value very highly in some situations while also being one of the highest contributors to personal misery in other situations. In the net though, definitely a keeper.

As you say, it leads you down a path. Often at the beginning there is pain, such as being painfully self-conscious. At the end of the path is often self-development though.

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#88
post #51

Vinod, often flashy and interesting, also often plays a bit fast and loose..a strategy that seems to land his lab good journals, but questionable replication. So I immediately looked at the preprocessing steps in the methods...which is, annoyingly, in supplemental 1. A few comments: It is written so vaguely, it is difficult to understand what preprocessing steps were done and in which order (which matters). The steps…

Is it too bold to say that any 10+ year old study claiming to have found across-subject brain x behavior relationship is not worth looking at closely?

Ha. I didn't even notice the date.

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#89

Earlier quoted context omitted.

> it's the non autistic people who have deficiencies in communication Example: In a Job interview, when you get asked why you did apply. Its the social norm to lie and make up some reason that sounds good, and saying the truth "i need money to pay my rent" makes you the weird one. People say ND people are blunt and frank... but the other side of the same coin would be that NT people can't talk about facts.

> Example: In a Job interview, when you get asked why you did apply. Its the social norm to lie and make up some reason that sounds good, and saying the truth "i need money to pay my rent" makes you the weird one This question has been included (not by my choice) in some hiring loops where I’ve been an interviewer. There are a lot of good answers that are definitely not lies. You see a lot of candidates who actually…

Good points, I appreciate the perspective! But, as someone probably on the spectrum, I still feel like the point about "NT people can't talk about facts" holds up.

Like, if someone replies, "I need the money etc" why can't NTs better clarify what they mean? For example, "Okay but why this company/role/specialty" as opposed to ?" If someone lacks the self-awareness to narrow down what they're looking for in a case like that, and just writes off the interviewee as deficient somehow, I'm happy to label the interviewer as being bad at "talking about facts".

I've had a case where I got a similar kind of prompt, and I asked a clarifying question to better get at what he was looking for, and he replied, "Just, whatever you interpret that to mean."

Like, what? You're the one asking the question, and you don't know what you want out of it? You'll knowingly let the interviewee "interpret" it, in a possibly incorrect way?

There was a reddit thread I'll try to find where they were asked "What's your favorite drink" and they replied "water" to which the follow-up was "come on, you can do better than that". A lot of commenters said, "oh yeah obviously that was an attempt to get you to see if you can intelligently defend your preference" or whatever. Okay, but the interviewer can also clarify what they're looking for!

Is it really (always) a bona fide occupational qualification to be able to guess the wishes of someone who's making no effort to express them on their own end?

Re: Brain Hyperconnectivity in Children with Autism and Its Links to Social Deficits (2013)

#90

Vinod, often flashy and interesting, also often plays a bit fast and loose..a strategy that seems to land his lab good journals, but questionable replication. So I immediately looked at the preprocessing steps in the methods...which is, annoyingly, in supplemental 1. A few comments: It is written so vaguely, it is difficult to understand what preprocessing steps were done and in which order (which matters). The steps…

Amusing comments provided you are not Vinod. Three sites and I would hope that connectomes were computed interleaved between cases and controls and analyzed with blinding. Is that standard? Do you think behavioral difference in the scanner could generate false positive connectome differences?

I am not sure what you mean by interleaved here. In 2013 I am not sure that site differences were as appreciated as they are today. Today, in studies that use multi-site imaging data, ComBat Harmonization is often the method that is employed to account for site effects in two ways: (1) it models site-specific scaling factors and (2) it uses empirical Bayes to improve the estimation of the site parameters for small sample sizes. https://pmc.ncbi.nlm.nih.gov/articles/PMC5845848/
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