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Living with Nausea: My Story in Six Charts

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Re: Living with Nausea: My Story in Six Charts

#11
My feeling is this was caused by COVID damaging the neurons or receptors of the stomach or duodenum, or, more likely that COVID caused a Magnesium Deficiency:

https://pmc.ncbi.nlm.nih.gov/articles/PMC10445067/

But some thoughts:

If the stomach is not emptying it means it is not getting the signal to empty.

Some of his symptoms signal high serotonin (panic attack, nasuea)

https://www.nature.com/articles/1300880

Anti-nasuea meds block the serotonin HT3 Receptor.

https://www.ncbi.nlm.nih.gov/books/NBK513318/

But the lack of gastric emptying is mostly controlled by high Cholecystokinin (https://www.uniprot.org/uniprotkb/P06307/entry)

https://pubmed.ncbi.nlm.nih.gov/645853/

Now it could be that his Cholecystokinin receptors are not getting this signal from the Cholecystokinin, or, since these are G Protein Coupled Receptors, that there is not enough GTP in the cell to create the cAMP needed for the stimulation to carry on down stream.

https://www.nature.com/scitable/content/ne0000/ne0000/ne0000...

To make GTP you need magnesium:

https://pmc.ncbi.nlm.nih.gov/articles/PMC3400779/

Magnesium is one nutrient found deficient in Gastroparisis:

https://pubmed.ncbi.nlm.nih.gov/2012043/

Not to mention that low magnesium is linked to worse COVID outcome.

Also, he said he had some tardive dyskinesia from some meds which would also point to low magnesium since low magnesium is linked to the disorder:

https://pubmed.ncbi.nlm.nih.gov/27816557/

Why did the ginger help? That is easy:

It triggers cholecystokinin signaling by activating the TRPV1. So more spicy foods will probably help as well. BUT, this to me would not be a long term solution since IMHO it would lower magnesium even more.

https://pmc.ncbi.nlm.nih.gov/articles/PMC11192538/

EGCG in green tea also triggers this receptor.

So it may be that he has some genetic issue with his Cholecystokinin receptor genetics that made him more vulnerable to a magnesium deficiency caused by COVID.

https://www.scirp.org/journal/paperinformation?paperid=11741...

Re: Living with Nausea: My Story in Six Charts

#12
Hey there, i have crohns' which isn't nausea based for me but definitely i understand the debilitating nature of gastrointestinal issues. It really just kills your ability to think, to talk socially, it completely and totally stole my adolescence. I'm sure you've done endless research, I'm not gonna tell you i have a cure. But if you haven't, you should look into gut microbiota. My understanding is that the balance of types of bacteria in the stomach and intestines has so so so much more to do with our daily experience than anyone realizes. And that any kind of infection or antibiotic regiment or just normal living can precipitate a change in the balance that just obliterates peoples lives. And we just don't know much at all about it yet. I've seen many people talk over the years about experimenting with different probiotics, even down to ordering exact strains of bacteria to make yogurt and test. If you need a new path to research and try things you can look there. As i said, doctors don't know much about it yet so it you probably can't find one to guide you through it. You'll have to figure it out, but it's possible, people have been helped, and at the end of it all, i hope it gets better for you. <3

Re: Living with Nausea: My Story in Six Charts

#13

I apparently have a food allergy. I thought it was acid for years. It wasn't until I moved somewhere with much higher pollen levels that my stomach symptoms were way worse and I noticed the cross-reactivity. Usually allergies are faster but when it's not it the food makes it into your stomach and your whole body has issues. It's something I'm still kind of figuring out as we speak. Some people I think call it a mast…

I had (have) an undiagnosed gluten allergy, and had similar issues for a couple years until I tried cutting wheat and other sources of gluten out of my diet and felt like a normal human being again within two days.

Re: Living with Nausea: My Story in Six Charts

#14

I apparently have a food allergy. I thought it was acid for years. It wasn't until I moved somewhere with much higher pollen levels that my stomach symptoms were way worse and I noticed the cross-reactivity. Usually allergies are faster but when it's not it the food makes it into your stomach and your whole body has issues. It's something I'm still kind of figuring out as we speak. Some people I think call it a mast…

I had (have) an undiagnosed gluten allergy, and had similar issues for a couple years until I tried cutting wheat and other sources of gluten out of my diet and felt like a normal human being again within two days.

You have to be careful with suggesting to cut out X/Y/Z foods. Said another way, I would recommend OP eat a bag of gluten and see if they end up in the hospital you'll have your diagnosis in 15 minutes and then there'd be no argument.

I'm not speaking about you specifically, parents get the cutting out X/Y/Z food wrong with their kids all the time. It makes people afraid of eating instead of afraid of what they're allergic to. Unless you maintain a strict food journal which I don't have time for why not just take 2x dose of Zyrtec (I'm just a happy customer) for a week, then try the gluten/paleo/soylent/steve jobs diet.

Edit: I am not a medical doctor and taking an antihistamine to mask a food allergy is probably dangerous but I'm still testing myself. OP said they tried Dramamine, which is an antihistime. I've taken that along with many antacids including Nexium and Pepcid which are also antihistimine. Maybe mast cell disorder is what doctors have to call it so someone with a peanut allergy doesn't read this and reaches for zyrtec and a bowl of peanuts and throws out their epipen. That's why I mentioned the pollen cross-reactivity because I think my body is just overreacting so I'm making the executive decision to suppress it. It's been 8 months or so, I've not taken a single Nexium, only a couple pepcid which for my family is basically cured. I moved somewhere with less pollen because I don't like taking pills all the time.

Edit-Edit (I'm really focused on this topic lately): The bottom line is that I reduced my cetirizine use from 15–20 mg/day to about 5 mg/day by moving to a place with less pollen.

If you're experiencing something similar, pay attention to any systemic symptoms and listen to your body. I had eliminated almost all food from my diet to control my gastric issues. But my left ear was having tinnitus. They checked it, they said my ears are very clean and thought it might be middle ear problems. They gave me a list of antihistimines and a nasal steroid (flonase) to try. I channeled my oppositional energy and thought, "Well, if they want me to try it…"

So I bought the entire list they gave me, I took cetirizine once a day, loratadine twice a day, and occasionally a fexofenadine pill (along with my usual double dose of Nexium, which I was desperate to discontinue) plus the Flonase for good measure.

I started cetirizine to manage tinnitus and dizziness, which are entirely separate systemic symptoms that I had never associated with my gastric symptoms or food.

A few days later, my ears cleared, and all my gastric/reflux symptoms disappeared. I quit all antacids on the same _day_. When my middle ears drain, that's my canary in the coal mine. It had worked so well that I wondered how long I had been suffering before I moved to Pollenville in the first place and just didn't notice.

Thanks Pollenville. You were my bag of raw gluten powder.

Re: Living with Nausea: My Story in Six Charts

#15
The emotional turmoil of trying to get help from the medical system with an unknown chronic illness can be just as bad or worse than the illness itself at times. I hope the author gets to the bottom of things and is able to find treatment or treat themselves.

Re: Living with Nausea: My Story in Six Charts

#16

So my kid has ARFID. I am not a doctor, but what I have learned is that eventually, anything that causes nausea associated with eating can progress into ARFID, even if the original underlying cause resolves. ARFID is technically an eating disorder, like anorexia, but it isn't related to poor body image; it is, basically, a food aversion to, well, food. All food, or nearly all. This is what happened to my kid; there’s…

Your son’s serotonin in his gut may still be high. Please do not assume that the nausea is related to a psychological disorder. My parents did this with me and it turns out my case was a lot more complicated.

I don’t know if you tried antinausea medication that blocks the serotonin HT3 receptor but if you try that and the nausea goes away, I would look ant increased serotonin release as a culprit instead.

Re: Living with Nausea: My Story in Six Charts

#17
Hi author,

I have an uncannily similar physical and symptomatic profile. Do you experience anxiety? My symptoms were so intense and unpredictable that I developed anxiety from it. I had to learn to manage and distinguish both issues, which helped a ton. I never had any formal diagnostic as every doc basically says "everything's normal", but I now suspect a heightened stomach sensibility due to multiple COVID-19 infections coupled with a highly stressful period in my life. I haven't had COVID in a while now and my stress levels are much lower so symptoms are mostly gone.

I understand how debilitating and hellish it can be. I wish you all the best!

Re: Living with Nausea: My Story in Six Charts

#18
If the author is reading this, might want to consider the possibility of an onset of chronic "silent migraines" which can have quite the nauseating effect but without the headache. I suffer from them and they are debilitating. While reading your article, I kept thinking it would eventually get to the part where you discovered you are having migraines (which also tend to run in cycles of a couple weeks to a month for many people, myself included), but no mention of this anywhere, so thought I'd point it out.

Re: Living with Nausea: My Story in Six Charts

#19

So my kid has ARFID. I am not a doctor, but what I have learned is that eventually, anything that causes nausea associated with eating can progress into ARFID, even if the original underlying cause resolves. ARFID is technically an eating disorder, like anorexia, but it isn't related to poor body image; it is, basically, a food aversion to, well, food. All food, or nearly all. This is what happened to my kid; there’s…

Your son’s serotonin in his gut may still be high. Please do not assume that the nausea is related to a psychological disorder. My parents did this with me and it turns out my case was a lot more complicated. I don’t know if you tried antinausea medication that blocks the serotonin HT3 receptor but if you try that and the nausea goes away, I would look ant increased serotonin release as a culprit instead.

https://www.ncbi.nlm.nih.gov/books/NBK603710/

"Research regarding ARFID is still emerging; the role of serotonin in sensory processing and anxiety suggests a potential mechanism through which neurotransmitter dysregulation could influence the disorder. Moreover, sensory processing issues, which are not exclusive to ARFID but are also present in other conditions (eg, autism), may be associated with abnormal serotonin function, further supporting the need to investigate serotonin's role in ARFID"

https://pmc.ncbi.nlm.nih.gov/articles/PMC305267/

Re: Living with Nausea: My Story in Six Charts

#20
post #15

The emotional turmoil of trying to get help from the medical system with an unknown chronic illness can be just as bad or worse than the illness itself at times. I hope the author gets to the bottom of things and is able to find treatment or treat themselves.

Yes when this happens you become a project manager trying to persuade resources you have no control over to get on board. And you are paying for them. And they may give you bad advice. And you feel like shit and don't want to do it.
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