They're going to change, where humans sit in the loop and how they program will change, probably a good blend of procedural control and object-oriented processes, where the agents are considered objects and process flow is defined in the procedural methods, but don't freak out there's still a ton to do.
There are many design principles we can leverage to enhance human participation and fulfillment instead of just replacing them. Lights out manufacturing hasn't taken off, why would we think a lights out society would work any better?
Edited for formatting.