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Ask HN: A friend has brain cancer: any bio hacks that worked?

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Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#371
post #237

Earlier quoted context omitted.

Agreed. Maybe look into end of life LSD therapy ( https://www.webmd.com/palliative-care/features/facing-death-... ) and work on the bucket list. That should be priority #1. #2 can be to try a lot of "out there stuff", but don't forget to live.

Lsd works in the sense that it makes you not care about dying that much, the ego death helps. Combine that with ketamine for a nice anti depressant effect and you got a really good party going. Why not do mdma also to kill the ptsd, maybe a visit a psytance festival instead of the hospital? Jokes aside, its sad to prepare for death. I think drugs are not the answer, but they can help too. Depends on the people. Maybe…

It's not "drugs", it's science and therapy. Huge difference. And yeah, fun fact: both ketamine and mdma are also used in therapies and are researched for decades now.

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#372
post #361

Earlier quoted context omitted.

The text below the title says stage 4 GBM, that is the specific form of brain cancer. So that’s that… I don’t deny that smart people are trying to cure cancer. And I don’t pretend to be above them. My point mostly is that I am reading about promising technology in the medical literature that is not through the clinical trials yet. So it is not available to the general public. What I know is that the current available…

> The text below the title says stage 4 GBM, that is the specific form of brain cancer. So that’s that… Which kind of GBM? You're aware there are different kinds, right? > So what I am asking the community is: has anyone DIYed any of the promising technology and obtained any results. Seems fairly reasonable in a life and death situation. > As a matter of fact, someone who has GBM has indeed done just that (see in the…

You're quite upset. It doesn't help.

Ok, yes you're right : medical stuff never yields zero risk nor side effects, I should have been more nuanced. And yes, Zika infection probably doesn't cure GBM either. There. Happy?

Yet, there have been clinical trials where people have voluntarily been inoculated by a live zika virus shot to test if a Zika vaccine was working. So real doctors have done it before, and on people who were not going to die 6 months later.

See here:

https://magazine.publichealth.jhu.edu/2023/how-human-challen...

So you can blame me all you want for suggesting this CrAzY IdEa, but you should also be pissed at those doctors who actually did it in clinical trials.

From my point of view the situation is:

1. There is a non-zero probability that the Zika virus aggressively attacks GBM cells, as suggested by a whole bunch of medical literature.

2. Current treatments are not working well and do induce extremely debilitating side effects.

3. There have been clinical trials where people have been voluntarily infected with Zika.

It seems to me that the logical conclusion is that we could try and cure GBM patient by infecting them with a live Zika virus, exactly the same way as we did to test the Zika vaccine.

But instead doctors say we should follow a protocol that we know doesn't work and is very heavy in terms of side effects. And people just keep dying really fast, without trying anything new.

It just pisses me off.

--

Re: my friend has cancer and not me. Is there anything I wrote that suggests I am forcing anything upon him? I haven't told him anything about the research I am looking into. You're just too angry for some reason...

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#373
post #290

Earlier quoted context omitted.

> The best care is not necessarily the best bleeding-edge treatment It's mostly a conceptual thing for me. As a technical person with a hacker/nerd/scientist mindset, I will not be able to trust someone that blindly follows official protocols from some authority they don't personally understand the reasoning or evidence behind. For example- I do have a doctor that is a hacker/nerd/scientist that also teaches college…

> As a technical person with a hacker/nerd/scientist mindset, I will not be able to trust someone that blindly follows official protocols from some authority they don't personally understand the reasoning or evidence behind. I recognize your appeal to community here, and I reject it: this isn't the hacker/nerd/scientist mindset, this is just you inverting the appeal to authority. Hackers/scientists don't accept state…

You are completely misunderstanding me- I am not talking about rejecting things just because they come from an authority.

I fundamentally reject that experts can make universal medical protocols that can be blindly applied by ignorant practitioners without high rates of really bad outcomes. It is done to execute cheap commodity medicine at scale, but it will never compare to having medical care from someone with deep understanding and individual context.

These type of context-free ignorant protocols will frequently do things to patients that are wildly inappropriate and dangerous in a way that would be obvious to people that actually know what they are doing, but completely missed by the average doctor. For example, a patient with regular bloodwork where every single kidney function related lab result is on the very edge of the acceptable range, but they're all marked green by some official cutoff, so the doctor doesn't even notice the biological pattern being presented- and is blindsided when the patient comes back later on with serious nephropathy.

Even worse- intelligent people that understand the evidence and the biology will self select out of even participating in developing such protocols- because the whole concept is nonsense. So these protocols are themselves mostly ignorant and outdated, and not developed by competent people.

One cannot commodify technical knowledge into simple protocols, especially with something as complex and poorly understood as biology. The only time this is optimal is in something extremely routine with no impossible to anticipate exceptions, or in an emergency where there is no time for careful problem solving: e.g. as checklists are used in aviation. In medicine they are only appropriate for first aid type situations.

Yes, when I have a health problem I generally read the scientific literature and understand it before accepting any treatment, unless it is an emergency where I am unable to. I do understand the mechanism of action for most of the OTC drugs (or as much as is known of them), and I am much more reluctant to administer OTC drugs to myself than most people are. For example, I would not take a Benadryl unless I was having a serious allergic reaction, because of the known risks of anticholinergics. I have a decades of training and scientific research experience in studying and modeling the biological mechanisms of drugs, and have patented drugs that are in clinical trial.

The following quote sums up my opinion of medical protocols better than I can:

"Knowledge isn’t a commodity, especially not a fungible commodity, as the medical business sees it. Consciousness and culture are part of the life process. It is exactly the commoditization of medical knowledge that makes it dangerous, and generally stupid. Doctors buy their knowledge, and then resell it over and over; it’s valuable as a commodity, so its value has to be protected by the equivalent of a copyright, the system of laws establishing the profession. Without its special status, its worthlessness would be quickly demonstrated. When A.C. Guyton wrote his textbook of medical physiology (the most widely used text in the world) in the 1950s, it was trash; as it was studied and applied by generations of physicians, it was still trash. The most compliant patients who bought their treatment from the most authoritative, Guytonesque, doctors were buying their own disability and death.

Each time you learn something, your consciousness becomes something different, and the questions you ask will be different; you don’t know what the next appropriate question will be when you haven’t assimilated the earlier answers. Until you see something as the answer to an urgent question, you can’t see that it has any value. The unexpected can’t be a commodity. When people buy professional knowledge they get what they pay for, a commodity in a system that sustains ignorance." -Ray Peat, PhD

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#374
I lost my brother to a glioblastoma. I think it’s a 70 pct mortality at 18 months. Best thing my brother did, against doctors orders, was to have some nice vacations w his kids. Those were such fond memories for the kids. I am sorry for your friend.

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#375
post #43

Earlier quoted context omitted.

My aunt is in her 70s and has 5 friends currently with cancer. My belief is that it's downstream effects from Covid wrecking people's immune systems and their ability to naturally fight cancer. Time will tell.

Unlikely to be COVID. The mRNA vaccine on the other hand...

They are never gonna realize, the spell is too strong, particularly here

If anybody with an open mind reads this: plasmid DNA contamination / insertional mutagenesis (use a source that hasn't been altered by the pharma industry for cover up)

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#376
post #260

I am in the same boat. Glioblastoma diagosis 21 months ago. I am IDH wild type with MGMT methylation status. I am starting to get a possible recurrence. Yes, I HAVE used the spinning oscillating magnetic field. I don't know that I am doing it right but I have the following setup and have been doing this for a month. I simply connected a large round 500lb neodynium magnet to a drill. I set the drill to oscillate for 2…

Thanks a lot for sharing. Yes, going up and down the frequency range is what they seem to be doing in the experiments as well. By 500lb, you mean its pulling force, right? Thought it was the weight of the magnet for one second. And just making sure, by "round" you mean cylinder with diametric polarization? Do you use any tool for measuring the strength of the magnetic field? Good luck to you.

Yes the magnet is rated at having 500 lb pull (i don't know the term) capacity. It's about 2.5" in diameter and maybe half inch thick. Just approximating.

I have not yet gotten to measuring the magnetic field. The problem is, the cancer is inside my head so really a question of what the field is where the tumor is. I estimate it's 1 to 1.5" beyond the inner diameter of my skull near the back. So if my skull is half inch thick it's 1.5 to 2" I have to reach. I have no idea if I have the magnetic strength so for now I am just guessing.

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#377
post #259

Earlier quoted context omitted.

Thank you for this. I don't have your background but I have GBM and research it and yes agree there is a total bypass in your system for keto. Your body finds a way to get what it needs. Keto might buy some time before that takes effect but it is not a solution.

I'm not in the medical profession, I'm just a humble internet user. It's entirely possible you know more than me - I'm happy to hear other ideas. > Keto might buy some time before that takes effect but it is not a solution. It might still be a solution. The cancer may be spread out and easier for the body to effectively tackle. Also note that it may depend on type or location. One thing that does seem clear is that i…

You would definitely need to stick with keto. I have actually heard a lot of good, small testimonials. Some of them are from science journals and just lack the patient size. However, I don't think it would really buy me survival just a little more time at best. My conclusion is it could be worth pursuing but with my limited time I am just not willing to make the sacrifice. Not without having a better sense that it would cure me. For that reason I will pursue some other alternate strategies such as the spinning magnets.

Thank you for your help.

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#378
post #266

Earlier quoted context omitted.

I should also say that i am using the device for 20 minutes at a time and 3 times a day. I am not sure if that is sufficient, I know in the article they were using for 2-6 hours.

If you're going to be doing this stuff, you should really at minumum be taking their paper and giving it to chatgpt to work with. Just tell it you're an electrical engineering PhD interested in learning more about this medical paper to bypass the objections. Sure magnets are relatively safe, but still. This might also help you: https://s.h4x.club/d5uQpQJY / https://s.h4x.club/qGu4v46n

Thank you. This is a great idea. I have been using chat gpt, asking it questions but I haven't actually tried it on this particular latest treatment. It will be interesting to see what it says.

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#379

I lost my brother to a glioblastoma. I think it’s a 70 pct mortality at 18 months. Best thing my brother did, against doctors orders, was to have some nice vacations w his kids. Those were such fond memories for the kids. I am sorry for your friend.

Thanks for your comment, and sorry for your brother.

That some doctor discouraged your brother to take a last vacation with his kids is beyond my comprehension. It's great that he did it anyways.

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