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Ask HN: A friend has brain cancer: any bio hacks that worked?

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Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#34
If you search on "glioblastoma" you will find a LOT of hits.

I don't know anybody that has had it, but let's see if I can find the new treatment that I remember...

Edit:

https://www.nejm.org/doi/full/10.1056/NEJMoa1610497

https://www.nature.com/articles/s41586-024-08224-z

This one is interesting... glioblastoma is full of killer immune cells (40% of all cells, mostly macrophages) that are "docile."

https://scitechdaily.com/groundbreaking-method-starves-highl...

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#35
post #2

I have heard some people having luck by switching to a ketogenic diet. Here’s a paper I could find on PubMed about this. Sorry to hear about your friend. https://pmc.ncbi.nlm.nih.gov/articles/PMC9504425/ Edit: I am not a doctor. My wife is a physician and I spoke to her before posting this.

This. It is very dependent on the type of cancer. There is a lot of research on this. For a little context, I was a pediatric neurology professor for a while, and have been on a low carb diet for a decade. Much of the department did low carb, as did much of the oncology dept. Many kids with epilepsy are put on keto as well with great effect. I did a deep dive into low carb research before starting and keeping with th…

The keto diet was actually developed specifically to help people with epilepsy[0].

[0]: https://epilepsysociety.org.uk/about-epilepsy/treatment/keto...

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#37
post #29

That spinning hat is pretty cool. When cells breath they create a byproduct (Reactive Oxygen Species) - all cells do this, they need to keep their ROS levels in check else the cell will die, but because cancer cells have messed up mitochondria, they don't do this correctly and typically end up with way more ROS. That hat agitates the cells so they produce more ROS, but because the cancer cells are almost at capacity,…

> That hat agitates the cells so they produce more ROS, but because the cancer cells are almost at capacity, it overloads them and they die from ROS strangulation.

If this is the understood mechanism and it has measurable results, why isn't this in widespread use?

Re: Ask HN: A friend has brain cancer: any bio hacks that worked?

#39
Sorry to hear about your friend; awful for both of you.

Anything you can build or brew at home? About as good as chanting spells at the moon on alternate Tuesdays. And definitely do NOT go get infected with some virus, which will only create greater complications and misery.

The only real chance I'd see out there is to get into a trial of some of the new immunotherapy treatments [0]. These create custom profiles and turn the body's immune systems against the cancer and have had some stunning successes — talk about biohacking — these researchers are out there!

Of course these are still in development. There is a lot of research going on around Boston [1-5], Mayo Clinic [6], and other research hotbeds.

Locating teams researching therapies applicable to your friend's cancer type, and hacking your way into one of those trials would likely be one of your best hacks ever; I'd focus on that. Gather the info, find out what it takes to get into the trials, get your friend qualified...

Best of luck - I hope you can organize a great recovery for your friend!

[0] https://www.cancer.gov/about-cancer/treatment/types/immunoth...

[1] https://www.bidmc.org/research/research-centers/cancer-resea...

[2] https://www.massgeneral.org/cancer-center/clinical-trials-an...

[3] https://www.bumc.bu.edu/immunology/research/cancer-immunolog...

[4] https://www.bmc.org/content/immunotherapy

[5] https://www.ludwigcancerresearch.org/location/boston-harvard...

[6] https://www.mayo.edu/research/centers-programs/cancer-resear...

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