Urgh some ungodly JavaScript is hijacking the scrolling, I wish the site wasn't so ineptly written.
And no « reader mode » possible. Totally unusable for me!
Dog Aging Project
21–30 of 133 posts
Re: Dog Aging Project
#22So when i join the project, my dog becomes a guinea pig for testing Rapamycin?
I didn’t know that molecule. It’s an immunosuppressant, isn’t it a bit counter productive for old people that tends to be weaker?
Re: Dog Aging Project
#23Urgh some ungodly JavaScript is hijacking the scrolling, I wish the site wasn't so ineptly written.
bahaha usually when HN people are complaining about a website I think they're being dramatic but the way this was scrolljacked, it's almost like it's designed to frustrate you
Re: Dog Aging Project
#24Are there other examples of innovations flowing from veterinary medicine to human medicine?
malaria parasite discovered when researching cattle disease.
Re: Dog Aging Project
#25So when i join the project, my dog becomes a guinea pig for testing Rapamycin?
I didn’t know that molecule. It’s an immunosuppressant, isn’t it a bit counter productive for old people that tends to be weaker?
The idea is to inhibit mtor which regulates a lot of processes in the body that affects aging. The immunosuppressant effects are a side-effect.
If it works? It was promising but latetly it looks more unlikely.
Re: Dog Aging Project
#26Are there other examples of innovations flowing from veterinary medicine to human medicine?
Euthanasia.
Re: Dog Aging Project
#27Are there other examples of innovations flowing from veterinary medicine to human medicine?
> other examples of innovations flowing from veterinary medicine to human medicine
“As microbial and genetic discoveries were made, pathogenesis studies were required to integrate the new knowledge into useful clinical advances. Those advances include a creative model of enteric bacterial disease (Moon), demonstration of the transmissibility and pathogenesis of scrapie, a proposal that human kuru was a transmissible spongiform encephalopathy (Hadlow), and the isolation of bovine leukemia virus (Miller) and bovine immunosuppressive retroviruses (Van Der Maaten)—5 years before AIDS and HIV appeared. Now modern molecular and genetic sciences and their applications in integrative, whole-animal biology make possible exciting advances for the benefit of both animals and people” [1].
(Counterfactual: “major methodological limitations of the animal research and evidence of widespread publication bias” limit translatability [2].)
Re: Dog Aging Project
#28So when i join the project, my dog becomes a guinea pig for testing Rapamycin?
I didn’t know that molecule. It’s an immunosuppressant, isn’t it a bit counter productive for old people that tends to be weaker?
Better thought of as an immune modulator than suppressant. Ultimately it’s a blunt tool when we lack more specific agents. Yes, it will have risks including infection, but the benefits may (or may not) outweigh the risks.
Re: Dog Aging Project
#29So when i join the project, my dog becomes a guinea pig for testing Rapamycin?
I didn’t know that molecule. It’s an immunosuppressant, isn’t it a bit counter productive for old people that tends to be weaker?
> isn’t it a bit counter productive for old people that tends to be weaker?
Not if it’s running around fighting imaginary worms and generally inflaming everything.
Re: Dog Aging Project
#30So when i join the project, my dog becomes a guinea pig for testing Rapamycin?
> when i join the project, my dog becomes a guinea pig for testing Rapamycin?
They remain a canine. But yes, they become a research subject.