121–130 of 159 posts
Anyone can mix chemicals in a test tube and claim it’s the cure for something. That’s the easy part. Proving it’s safe and effective, that’s what requires a lot of capital expenditure. This statement is a drastic characterization, but you could say “half a dozen PhDs can form reasons to believe they may have found a cure for something”, and the paragraph would end the same.
Earlier quoted context omitted.
https://247wallst.com/media/2024/08/04/9-biggest-video-game-...
There is certainly a difference between profit and revenue, yes.
That's interesting. I was just reading about how high dose IV vitamin c can induce cell death in a wide variety of cancers, but somehow, despite this being known for decades, nobody has done rigorous research on it. https://www.cancer.gov/research/key-initiatives/ras/news-eve... From what I can tell there are several things like this - that have promising anti cancer effects, that just don't really get that much atte…
Deeply disappointed by the comments replying to this. I would reply to each individually, but feel like I'd get throttled by hackernews, so I'll just reply to everyone here. --- shepherdjerred writes that this is unlikely because doctors want what is best for their patients and would notice a cure were it available. This is kind of true. Some doctors do know about and prescribe vitamin c with typical therapy. Here is…
People writing completely half-baked, often deeply ignorant opinions on complex, nuanced subjects out of mostly emotional disdain, but phrasing their responses in such a way as to easily fool someone who doesn't know said subject well that they at all know what they're talking about and are thus arguing rationally.
Anyone can mix chemicals in a test tube and claim it’s the cure for something. That’s the easy part. Proving it’s safe and effective, that’s what requires a lot of capital expenditure. This statement is a drastic characterization, but you could say “half a dozen PhDs can form reasons to believe they may have found a cure for something”, and the paragraph would end the same.
Got my PhD from a lab that works on antibody drugs, they eventually even released one to the market. I’d argue that our current system is broken. There’s no reliable metric of drug effectiveness in any of our pre-clinical models, and thus we end up going into clinical trials quite blind indeed. And more often than not, what drug gets into trials has more to do with ego and politics than actual scientific merit. And t…
That being said, we're talking about human lives either way so it needs to be thought through and avoid unintended disasters through lack of care.
Earlier quoted context omitted.
> That's interesting. I was just reading about how high dose IV vitamin c can induce cell death in a wide variety of cancers, but somehow, despite this being known for decades, nobody has done rigorous research on it. Sigh. Vitamin C quackery again. Vitamin C at high doses is cytotoxic, so it works against rapidly dividing cells. Cancer cells also preferentially concentrate vitamin C because they are under oxidative…
There is evidence that high doses of antioxidants can make cancer worse , probably because cancer cells are under oxidative stress. https://www.cancer.gov/news-events/cancer-currents-blog/2015... https://pubmed.ncbi.nlm.nih.gov/8127329/
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> That's interesting. I was just reading about how high dose IV vitamin c can induce cell death in a wide variety of cancers, but somehow, despite this being known for decades, nobody has done rigorous research on it. Sigh. Vitamin C quackery again. Vitamin C at high doses is cytotoxic, so it works against rapidly dividing cells. Cancer cells also preferentially concentrate vitamin C because they are under oxidative…
Thanks for providing a plausible explanation. Do you know of any links (ideally peer- reviewed research) supporting the quick evolution of resistance to vitamin C? If not I'll google around.
In the articles linked in this thread, large-dose vitamin C prolonged survival, but didn't clear the cancer. It's exactly what you'd expect from a chemo treatment.
Earlier quoted context omitted.
> That's interesting. I was just reading about how high dose IV vitamin c can induce cell death in a wide variety of cancers, but somehow, despite this being known for decades, nobody has done rigorous research on it. Sigh. Vitamin C quackery again. Vitamin C at high doses is cytotoxic, so it works against rapidly dividing cells. Cancer cells also preferentially concentrate vitamin C because they are under oxidative…
This was just published by UI showing a potent effect of high dose vitamin C + chemotherapy: https://medicine.uiowa.edu/content/high-dose-iv-vitamin-c-pl... and https://www.sciencedirect.com/science/article/pii/S221323172...
If federal funds are used to develop a medication or vaccine, it must not be patentable, otherwise it is a corporate welfare giveaway trading lives and poverty for money.
Earlier quoted context omitted.
Got my PhD from a lab that works on antibody drugs, they eventually even released one to the market. I’d argue that our current system is broken. There’s no reliable metric of drug effectiveness in any of our pre-clinical models, and thus we end up going into clinical trials quite blind indeed. And more often than not, what drug gets into trials has more to do with ego and politics than actual scientific merit. And t…
It doesn’t (have to) cost billions to bring a (successful) drug to market. And if you pick a single successful example that was discovered in academia, was spun out into a small focussed biotech, and was in a disease area that didn’t require large or multiple studies to make it to market, you’ll have your anecdote to prove your point. Except… you’d be ignoring the costs of the 90% of drugs that fail in phase 1. You’d…