Earlier quoted context omitted.
I think by keyed it isn't just "can't be plugged in upside down" but also "can't be plugged into the other plug that's basically the same but connects to some other subsystem." Ideally a system like this would let you select some per-subsystem physical lockout mechanism.
That level of keying would be done at the harness/electrical engineer level. You shouldn't put two same plug ends at one termination site. You really couldn't control it at plug or part level.
The plug manufacturer has to provide many, many keying options (say for a 2-pin plug, one might have variants 2A, 2B, etc... which explicitly cannot mate with each other)
An engineer designing the car has to ensure all plugs with same keying options are interchangeable (2A is for power supply; 2B for door switch; etc...)
If the plug manufacturer does not provide enough keying options, this will be pretty hard to during design time.