Live data from Hacker News

The brain's waste clearing lymphatic system shown in people for first time

nih.gov

81–90 of 111 posts

Re: The brain's waste clearing lymphatic system shown in people for first time

#81

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

Paul's animation wasn't playing at an even rate for me, for some reason, so I created two video versions (8Hz and 12Hz) with the 16 second on/off period, starting with an off period, running for 254 seconds, as per the paper. These versions end with an an additional off period, as a 'cool down' from the flicker. Framerate of 24Hz differs from the 120Hz as presented in the paper, but here there is no 40Hz flicker atte…

Wow! So a visual effect similar to some psychadelic hallucinations is associated with brain cleaning!

Also, I've been at concerts where the light show guy seems to have reverse-engineered the filters our brains use to process raw signal into "images", and could use the lights to create just the raw primitives.

A few hours of that and it was like I was learning to see all over again, a tune-up/calibration of my visual system.

Re: The brain's waste clearing lymphatic system shown in people for first time

#82
post #57

Earlier quoted context omitted.

Do you recall which position?

> Glymphatic transport is most efficient in the right lateral sleeping position https://pmc.ncbi.nlm.nih.gov/articles/PMC7698404/ Section 3.4.3

That's great that there's a way to passively optimize that process every day. But it's also bad news considering it's contrary to what you need if you have GERD.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10643078/

> A limited number of studies have demonstrated that sleeping in the left lateral decubitus (LLD) decreases nocturnal reflux in patients with gastroesophageal reflux disease (GERD) compared to right lateral decubitus (RLD) and supine.

Re: The brain's waste clearing lymphatic system shown in people for first time

#83
post #57

Earlier quoted context omitted.

Do you recall which position?

> Glymphatic transport is most efficient in the right lateral sleeping position https://pmc.ncbi.nlm.nih.gov/articles/PMC7698404/ Section 3.4.3

> Glymphatic transport is most efficient in the right lateral sleeping position, with more CSF clearance occurring compared to supine and prone [6]

Reference [6] is a study on rats! The authors suggest further investigation in humans.

Even though I would bet on this still holding for humans.

Re: The brain's waste clearing lymphatic system shown in people for first time

#84

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

The paper says they used http://psychtoolbox.org/ to generate the images.

> Psychophysics Toolbox Version 3 (PTB-3) is a free set of Matlab and GNU Octave functions for vision and neuroscience research

Scientists almost never want to share their code and it makes me sad. Why wouldn't they want to make their paper more easily reproducible?

Re: The brain's waste clearing lymphatic system shown in people for first time

#85

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

Paul's animation wasn't playing at an even rate for me, for some reason, so I created two video versions (8Hz and 12Hz) with the 16 second on/off period, starting with an off period, running for 254 seconds, as per the paper. These versions end with an an additional off period, as a 'cool down' from the flicker. Framerate of 24Hz differs from the 120Hz as presented in the paper, but here there is no 40Hz flicker atte…

What are you supposed to look at? The center red dot?

Re: The brain's waste clearing lymphatic system shown in people for first time

#87

Earlier quoted context omitted.

Paul's animation wasn't playing at an even rate for me, for some reason, so I created two video versions (8Hz and 12Hz) with the 16 second on/off period, starting with an off period, running for 254 seconds, as per the paper. These versions end with an an additional off period, as a 'cool down' from the flicker. Framerate of 24Hz differs from the 120Hz as presented in the paper, but here there is no 40Hz flicker atte…

Wow! So a visual effect similar to some psychadelic hallucinations is associated with brain cleaning! Also, I've been at concerts where the light show guy seems to have reverse-engineered the filters our brains use to process raw signal into "images", and could use the lights to create just the raw primitives. A few hours of that and it was like I was learning to see all over again, a tune-up/calibration of my visual…

It's like the Brown Noise for your brain!

https://www.youtube.com/watch?v=6ijI4HjTGkw

Re: The brain's waste clearing lymphatic system shown in people for first time

#88
post #42

Earlier quoted context omitted.

It seems to have no effect on me. Am I an outlier?

Maybe try it again at the end of the workday?

I tried it again several hours later, being more tired, and on my 22" fullscreen instead of my phone.

Still nothing.

Re: The brain's waste clearing lymphatic system shown in people for first time

#89

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

Paul's animation wasn't playing at an even rate for me, for some reason, so I created two video versions (8Hz and 12Hz) with the 16 second on/off period, starting with an off period, running for 254 seconds, as per the paper. These versions end with an an additional off period, as a 'cool down' from the flicker. Framerate of 24Hz differs from the 120Hz as presented in the paper, but here there is no 40Hz flicker atte…

[dead]

Re: The brain's waste clearing lymphatic system shown in people for first time

#90
post #76
post #41

Earlier quoted context omitted.

Very cool! Five minutes of this felt strangely soothing in my head, after a few nights of not enough sleep. Being able to set a max duration would be neat, in case it's unsafe to lose track of time and let the pattern run for too long? Classic outdated comment BTW ;) setInterval(flickerImage, 250); // 8hz

Isn't that 4 Hz?

Exactly, the comment was carried over from V0.1 which set a 125 ms timer.
Post reply on HN