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The brain's waste clearing lymphatic system shown in people for first time

nih.gov

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Re: The brain's waste clearing lymphatic system shown in people for first time

#51
post #41

Earlier quoted context omitted.

Very cool! Five minutes of this felt strangely soothing in my head, after a few nights of not enough sleep. Being able to set a max duration would be neat, in case it's unsafe to lose track of time and let the pattern run for too long? Classic outdated comment BTW ;) setInterval(flickerImage, 250); // 8hz

When I open the page, the image rotates for about ten seconds then vanishes. How do you watch it for five minutes? What did I do wrong?

As per the first line of the writeup on the page: It toggles between on and off every 16 seconds.

Re: The brain's waste clearing lymphatic system shown in people for first time

#52

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

It seems to have no effect on me. Am I an outlier?

Try lying down and then watching the screen.

Re: The brain's waste clearing lymphatic system shown in people for first time

#53

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

I’d like to see if anyone with Fatal Familial Insomnia has been treated with this pattern. I expected that insomnia stops this glymphatic clearance, and that’s what eventually kills them.

Re: The brain's waste clearing lymphatic system shown in people for first time

#54
post #41

Earlier quoted context omitted.

Very cool! Five minutes of this felt strangely soothing in my head, after a few nights of not enough sleep. Being able to set a max duration would be neat, in case it's unsafe to lose track of time and let the pattern run for too long? Classic outdated comment BTW ;) setInterval(flickerImage, 250); // 8hz

When I open the page, the image rotates for about ten seconds then vanishes. How do you watch it for five minutes? What did I do wrong?

[deleted]

Re: The brain's waste clearing lymphatic system shown in people for first time

#55
post #10

Earlier quoted context omitted.

This is some amazing work; and it also raises my belief that a Langford Basilisk is neurologically possible by about 25%

It's possible. But only for the brains of people with severe or undertreated epilepsy of carefully selected varieties. You can trigger a potentially fatal seizure by showing them an appropriately stimulating image. Which likely was a known concept to the author of the story. For the rest of us the negative feedback along the optical axis puts a stop to such shenanigans.

GenAI images sometimes do this to me. Not anything scary per say, but some of the faults make my brain feel weird as it tries and fails to interpret parts of the image that were "AI smeared".

Re: The brain's waste clearing lymphatic system shown in people for first time

#56
post #10

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

This is some amazing work; and it also raises my belief that a Langford Basilisk is neurologically possible by about 25%

Sure, we know imagery can cause fatal seizures so... yes.

Re: The brain's waste clearing lymphatic system shown in people for first time

#57

“Other studies have suggested that the glymphatic system may be most active during sleep.” Not only that but also the right sleeping position is relevant here. I don’t recall the scientist but he studied primates and their natural sleeping position, exactly this position also opens up the channels for the cerebrospinal fluid to flush the accumulated brain waste.

Do you recall which position?

> Glymphatic transport is most efficient in the right lateral sleeping position

https://pmc.ncbi.nlm.nih.gov/articles/PMC7698404/ Section 3.4.3

Re: The brain's waste clearing lymphatic system shown in people for first time

#58

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

In me, there seemed to be an illusion going on. It felt like a tunnel and it felt as immersive as a "dream world" (albeit a bit of a boring one). What I also noticed were the after image effects. A strong blue dot every time it flashed and circles divided into 8 sections like a star. This was trippy.

Noticed that as well. Very trippy

Re: The brain's waste clearing lymphatic system shown in people for first time

#59

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

Paul's animation wasn't playing at an even rate for me, for some reason, so I created two video versions (8Hz and 12Hz) with the 16 second on/off period, starting with an off period, running for 254 seconds, as per the paper. These versions end with an an additional off period, as a 'cool down' from the flicker.

Framerate of 24Hz differs from the 120Hz as presented in the paper, but here there is no 40Hz flicker attempt so it shouldn't be an issue.

Compression may affect the edges of the lines, but downloads are enabled.

8Hz version - https://vimeo.com/1023278230/8ad6db6234

12Hz version - https://vimeo.com/1023275135/378186db55

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