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The brain's waste clearing lymphatic system shown in people for first time

nih.gov

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Re: The brain's waste clearing lymphatic system shown in people for first time

#31

Post by llm_trw »

PaulKeeble wrote: post #4

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

Fascinating. Can you go into more details explaining what your understanding of the paper is? I'm reading it now but I'm not familiar with the field.

Re: The brain's waste clearing lymphatic system shown in people for first time

#32

Post by anal_reactor »

PaulKeeble wrote: post #24
LinuxBender wrote: post #20

Earlier quoted context omitted.

What is one supposed to experience or feel? Maybe my computer is too slow or my monitor is too small? I used to collect gifs that were similar to this just because they had a neat visual effect but neither those nor this image gives me any kind of experience. If I could find a private business that has an MRI I would pay cash to get a full body scan and then just a brain scan as I have always wanted one but hospitals…

After focussing on the dot for a few seconds the images appear to produce a tunnel or other change in effect from just images flipping, maybe a moving star. Then when the grey image appears you get an after effect of the overall image for about a second. Some feel a form of pressure or even light seizure sensation in the brain and have auditory experience like there was a sound that disappears each time the grey clea…

I don't feel anything either. Not sure why

Re: The brain's waste clearing lymphatic system shown in people for first time

#33

Post by shaganer »

feoren wrote: post #19
PaulKeeble wrote: post #4

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

Staring at the v0.3 produces an effect similar to something I'm able to do trigger manually on command. I've always had the feeling that I'm somehow triggering a "flow" in my brain, but I have no way to confirm what's actually going on. It's actually stronger when I trigger it manually, and it feels like it flows down my spine and eventually some weak signal reaches my extremities. (Maybe that means it's not CSF afte…

I'm interested in how you accomplish this. I can do something along the lines of that by getting myself heated. I actually get a hothead and a tingling comes up to my brain like it's passing in a channel. It could simply be a sensation rising within the brain though, without an actual transport of something.

I can focus better after but it doesn't clear my head, just use that frustration or anger to become determined.

Re: The brain's waste clearing lymphatic system shown in people for first time

#34

Post by shaganer »

khafra wrote: post #10
PaulKeeble wrote: post #4

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

This is some amazing work; and it also raises my belief that a Langford Basilisk is neurologically possible by about 25%

I'm interested to hear your reasons why you think it's closer to reality. I don't see why the discovery of the brain wastage system would help a brain crash from being possible. Edit: Just looked back at the post and that it involves an image causing the glymphatic system to react.

Re: The brain's waste clearing lymphatic system shown in people for first time

#35

Post by shaganer »

PaulKeeble wrote: post #4

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

I wonder how this will work with hypophantic and aphantic individuals (people with little to no "mind's eye" visual imagery), such as myself. Like would the effect still be registered the same as anyone else, or would it cause the imagery effect to lessen or be ineffective altogether?

Re: The brain's waste clearing lymphatic system shown in people for first time

#36

Post by sharpshadow »

“Other studies have suggested that the glymphatic system may be most active during sleep.”

Not only that but also the right sleeping position is relevant here. I don’t recall the scientist but he studied primates and their natural sleeping position, exactly this position also opens up the channels for the cerebrospinal fluid to flush the accumulated brain waste.

Re: The brain's waste clearing lymphatic system shown in people for first time

#37

Post by evanjrowley »

Karellen wrote: post #18
reverius42 wrote: post #13

Earlier quoted context omitted.

Thanks for introducing me to the concept! Just read the short story I assume you are referring to: https://www.infinityplus.co.uk/stories/blit.htm

Looks like it, according to Wikipedia: https://en.wiktionary.org/wiki/Langford%27s_basilisk Just read the story, thought it was very reminiscent of one of the plot points in Neal Stephenson's Snow Crash (1992) - until I noticed the publication date of 1988, 4 years earlier!

You'll also find a similar concept throughout David Foster Wallace's Infinite Jest (1996).

Re: The brain's waste clearing lymphatic system shown in people for first time

#38

Post by sithadmin »

feoren wrote: post #19
PaulKeeble wrote: post #4

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

Staring at the v0.3 produces an effect similar to something I'm able to do trigger manually on command. I've always had the feeling that I'm somehow triggering a "flow" in my brain, but I have no way to confirm what's actually going on. It's actually stronger when I trigger it manually, and it feels like it flows down my spine and eventually some weak signal reaches my extremities. (Maybe that means it's not CSF afte…

That just sounds like ASMR, which some folks can induce without external stimuli.

Re: The brain's waste clearing lymphatic system shown in people for first time

#39

Post by sithadmin »

elric wrote: post #12
jhrmnn wrote: post #3

Earlier quoted context omitted.

Looking up “brain MRI with contrast”, the biggest difference seems to be that in a regular MRI the contrast goes to the blood, but here it goes straight to the brain cerebrospinal fluid. You need open brain for that, so indeed doesn’t seem trivial.

Cerebrospinal fluid is produced in the brain, I would imagine that the contrast would end up in newly produced fluid as well, but maybe that assumption is wrong.

Even assuming that the contrast could show up in newly excreted CSF (maybe, maybe not), MRI contrast elimination half lives are very short (mostly all under ~2 hrs, excepting cases like renal dysfunction), and cerebrospinal fluid doesn’t replenish particularly quickly.

Re: The brain's waste clearing lymphatic system shown in people for first time

#40

Post by [deleted] »

khafra wrote: post #10
PaulKeeble wrote: post #4

There have been a couple of papers [1] that can induce this process while awake using particular image patterns as confirmed in an MRI. I think the NIH confirmation is running behind in the science, independent research is quite a bit ahead of them. I came across the paper on this last year and implemented a very simple page with the parameters they used [2]. There is a number of disease models that show reduced or n…

This is some amazing work; and it also raises my belief that a Langford Basilisk is neurologically possible by about 25%

[deleted]
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