Columbus was famously a devout catholic; his DNA suggests that he was of Sephardic Jewish descent, most likely from a family that underwent a forced conversion.
There are indications he may have been raised Jewish, and later converted to Catholicism. Or, converted but still close to Judaism. His choice to set sail for the New World on August 2, 1492, the exact date ordained for the expulsion of Jews from Spain does suggest he may have not converted yet. Further, It's also known that the family profession was weaving, a traditionally Jewish profession at the time and that Jew…
This is one of the least compelling pieces of evidence: one doesn’t set out for a cross-oceanic voyage on a whim. He had sponsorship from the Spanish crown and lobbied and prepared for years for the journey. His journey was formally sanctioned by the the royal family in April of the year he left.