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How long til we're all on Ozempic?

asteriskmag.com

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Re: How long til we're all on Ozempic?

#561
I hope that these drugs pull people back from nasty habits such that they eventually build the strength to do without them. As of yet, I do not see why it has to be a win-lose situation one way or the other. Crutches aren't evil - they are expedient while they are expedient.

Sometimes when you have a really strong habit, it becomes really hard to imagine yourself being otherwise. I welcome anything that helps people see beyond a prison they've put themselves in, as long as it doesn't put them in a worse prison.

Does Ozempic or whatever put one in a worse prison? This seems personal, and not a categorical matter.

Those who take it have a choice of how to develop their sense of identity in relationship to their treatment. It is here where the rubber hits the road - these abstract extremes of "you're suppressing your ability to grow" and "you're hopeless without it" are short-sighted and serve no good purpose.

Re: How long til we're all on Ozempic?

#562

A lot of people fail to realize that eating healthy and exercising is not enough for a lot of people who fight with their weight their entire lives. Ozempic and Wegovy are game changes and have real, tangible health benefits. One person told me, "No matter how much I eat or exercise, I have been 'hungry' my entire life. That ended when I started taking these drugs."

> One person told me, "No matter how much I eat or exercise, I have been 'hungry' my entire life. That ended when I started taking these drugs." I would change this to "No matter how much I eat, I have been hungry my entire life", because that's what my experience is. I'm nearly always hungry. Doesn't matter what I eat or how much of it. High protein, high fiber, moderate fat, low carb, all the steps people say cures…

Ozempic (or better, Zepbound) will solve that problem. I feel just like you, have had a similar experience, and I'm taking tirzepatide (Zepbound, basically) now.

Ignore the haters. Focus on what will make you successful.

> my doc won't give it to me

Get another one. You can have more than one. Go to one biased in favor of selling you the drug, if that is what works. It is your health. Your doc is not your mom, he is your advisor, it is your body and your choice what to take.

Compounded semaglutide is relatively inexpensive. And over time the brand name stuff will start to come down because they are being undercut by the compounds. Zepbound, for example, is now available direct to consumer for $550/month (5mg, and not an autopen so you can easily split the dose to make it last longer if that still works for you). Still pretty expensive, but for a life changing drug it is worth it. I also expect the price will continue to drop, probably quite a lot in the upcoming years.

Re: How long til we're all on Ozempic?

#563

A lot of people fail to realize that eating healthy and exercising is not enough for a lot of people who fight with their weight their entire lives. Ozempic and Wegovy are game changes and have real, tangible health benefits. One person told me, "No matter how much I eat or exercise, I have been 'hungry' my entire life. That ended when I started taking these drugs."

>eating healthy and exercising is not enough for a lot

That's because both these interventions when followed in the way they are commonly understood are near completely incorrect. I blame the govt/medical profession for this.

Other factors: again I blame govt/medical profession for this - example it's difficult to get unprocessed food unless one reads labels carefully. For example it is near impossible to get milk that is not fortified with vitamin D. As they say: the road to hell is paved with good intent.

Granted that even after doing everything right there will be some people who will be obese, but that would be the minority. Again the govt/medical profession is to blame - for example I've heard that infants/kids are now given around 30 vaccines. With so many variables that have changed in the environment it now becomes difficult to isolate what is causing the health issues that predispose people to a lifetime of ill health

Re: How long til we're all on Ozempic?

#564

One other note: the current peptide-based GLP-1 drugs are not likely to be the permanent solution. Injectables are just too problematic for that. Several companies are now working on more classic small-molecule drugs targeting the same receptors. So it's likely that in several years we'll get a pill with the same effects. Yes, there's technically a pill version of Ozempic already (Rybelsus), but it works by making th…

I'm curious what about injectables makes them specifically problematic for long term use? Diabetics already have to inject insulin for the rest of their lives, and an injectable version of the same drug usually has fewer side effects since it doesn't have to pass through your gut metabolism. I may be biased, I have no fear of needles and have injected myself with sex hormones every week for nearly 7 years, so adding…

They are more expensive. Autoinjectors are way more complicated than a pill bottle. You also can't freeze them, but they should be kept in a fridge.

Manufacturing standards also have to be way higher. I have no problem trusting Novo Nordisk to manufacture injectors safely, but I won't trust a random manufacturer from India or China.

The risk of accidental infection from injection also is not neglibible.

Re: How long til we're all on Ozempic?

#565
post #547

Earlier quoted context omitted.

I gained about 50 pounds the past decade and the past year I’ve been trying to lose it. I weighed myself at the beginning: 205 lbs I started running 30 minutes per day (heartrate training targeting about 140-150), every day, for 10 months. I kept my diet the same as before (though with a protein bar after the run). Weighed myself every week or two, always within a couple pounds of 205. In March I ramped up my runs to…

Running for 30 minutes is maybe 200-400 calories. If you trigger your body to eat more because of that or you are more lazy throughout the day because you’re tired after running, it’s a wash. Exercise is not the route to weight loss. It’s like 80-90% diet.

> It’s like 80-90% diet.

And if you diet, you lose weight temporarily and trigger your body to eat more because you're hungry. Your body doesn't want there to be a route to weight loss, so it blocks them pretty effectively.

Re: How long til we're all on Ozempic?

#566

I'd think it more likely that it'll be one of the next generation drugs, but I do agree with the premise that it will be really common. A few weeks ago I started a low dose of tirzepatide (aka Mounjaro, aka Zepbound) and the side effects are interesting. The biggest negative, which just takes adjustment, is drastically lower stomach capacity. Used to be that two eggs and two pieces of toast was breakfast. Now I bette…

> "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape. Studies show it just doesn't work. There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667. https://www.ncbi.nlm.nih.gov/pmc/…

I hear very often this theory that "it just doesn't work".

To be fair, I had also believed this for many years.

However, all the people who claim that "it just doesn't work", have never made any serious attempt to do "it", so they cannot know whether it does work or not.

I have been obese for more than a decade, during which I have made several attempts to lose weight, which have all failed, because they were not done in the right manner.

Then I have made a final attempt using the correct method, and I have lost about 35% of my initial body weight during about ten months, at a steady rate between 100 g and 150 g per day, i.e. about 1 kg per week.

This was more than 10 years ago and since then I have kept a constant weight. Because I have done this once, now I can control my weight and have any weight I want, even if I gain weight extremely easily. It is enough to eat one day like I was eating when I was obese to gain enough weight to require a week of weight losing diet to go back to the desired weight.

The rules for losing weight and maintaining the weight are very simple, but they must be observed and those who claim that "it doesn't work" never try to observe the rules, so it is entirely predictable that it cannot work for them.

First, it should be obvious that after losing weight one must eat differently as before, otherwise weight will be gained until reaching again the original weight.

To be able to control the weight, anyone who is or has been obese must stop eating until they feel satiated. At each meal, one must plan before beginning to eat how much to eat and then eat only the amount planned, never more than that. One must eat a fixed number of meals per day (preferably few, e.g. only two meals per day should be enough for an adult who has a sedentary lifestyle) and never eat between meals any kind of snacks or drink any sweet of fatty beverages. Between meals, only water or beverages without any calories (e.g. unsweetened herbal teas or tea or coffee) are acceptable intakes.

While losing weight, the most important thing is to weigh oneself every day with precise digital scales (with a resolution of 100 grams or less), at the same hour and in the same physiological conditions, i.e. in the same order with respect to meals and relieving oneself.

Whenever the weight is not less than the previous day, then the quantity of food planned for the current day must be diminished in comparison with the previous day. At the very beginning of losing weight there may be a delay, e.g. of a week or so between starting to eat less every day until the weight begins to decrease, but eventually it is possible to reach a steady state of a constant rate of losing weight per day.

When diminishing the amount of eaten food, only the carbohydrates and the non-essential fats must be reduced. The amount of proteins, essential fatty acids, vitamins and minerals must remain normal. To achieve this, one must eat a source of pure proteins, for example turkey breast or chicken breast or some kind of protein powders, so that eating enough proteins contributes only a minimum amount of calories. The rest of the nutrients can be provided mostly by non-starchy vegetables and perhaps by some supplements like fish oil. One could also eat almost anything that is not recommended, for instance chocolate, with the condition that the quantity is negligible, which can normally be achieved only when such treats are not eaten every day, but e.g. only once or twice per week.

These rules are simple and anyone who follows them will lose as much weight as desired. Obviously, this is easier said than done, because for the entire duration of the weight-losing diet one will be permanently hungry and one would tend to think about food and it will be difficult to resist temptations, so it is better to not keep in the house any kind of food that can be eaten immediately, without requiring some kind of preparation. Unfortunately, this is unavoidable and it is the price that must be paid. After the first few weeks, the hunger sensation diminishes in intensity and it always disappears for a few hours whenever you find some work to do that captures your attention.

As long as you do not want to follow such rules, you will not lose weight, but that is because you do not want to do it, not because it does not work.

Not wanting to do it is a valid reason, because one may abhor more the feeling of hunger during many months than being obese, but this decision must be described correctly and not be justified by the false claim that "it doesn't work". At least in my case, the improvement in my health and in what I was able to do (e.g. before losing weight climbing a few stairs would make me tired and sweaty) has made worthwhile any displeasure felt during losing weight and I have been very happy to have achieved that.

Re: How long til we're all on Ozempic?

#567

Earlier quoted context omitted.

I gained about 50 pounds the past decade and the past year I’ve been trying to lose it. I weighed myself at the beginning: 205 lbs I started running 30 minutes per day (heartrate training targeting about 140-150), every day, for 10 months. I kept my diet the same as before (though with a protein bar after the run). Weighed myself every week or two, always within a couple pounds of 205. In March I ramped up my runs to…

Its a pretty well known fact that exercise alone (unless you are doing extreme athlete training) is not going to change your weight without a change in diet. You can get healthier with exercise, but not smaller. That is almost entirely based on diet. Just think about it; your thirty minutes of running probably burned between 300-500 calories. That one protein bar probably has about 300 calories by itself.

> 300-500 calories

Put another way, up to a pound a week of weight loss, changing nothing about your diet.

Re: How long til we're all on Ozempic?

#568
post #451

My wife was interested in taking the Ozempic route, and I am not fond of drugs. We then started intermittent fasting together as a lifestyle, and it's been great. Losing weight while not restricting what we eat and feeling great as our body adapts and doesn't let us overeat. I just wonder about the long-term effects, but I'd rather take this risk than a drug like Ozempic.

We did this, this happened to us: after a while you or her may get extremely obsessed with food and eventually get to the point where you overeat as a form of 'freedom' until you just can't stop.

IF works until it doesn't, then it REALLY doesn't work. My wife had a breakdown before we realized something was incredibly wrong. YMMV.

Re: How long til we're all on Ozempic?

#569
post #381

Earlier quoted context omitted.

My view about obesity has shifted dramatically since Ozempic came out. Before this, I didn't think about it too much (I am not obese myself). I notice now that there is a LOT of judgement, bias(?), around obesity, that people, obese or not, carry with them [1]. I certainly carried that bias, and the reason I noticed it was because Ozempic is literally an external substance that you take that simply makes obesity go a…

The willpower frame actually works pretty well for a lot of people. If not than in our society almost everybody would be obese. This pill will make things worse for the group that hangs out in the treadmills and drinks green and disgusting smoothies. On topic, very happy this medicine exists, but let's pray god will keep the prescription only for BMI > 35.

> The willpower frame actually works pretty well for a lot of people. If not than in our society almost everybody would be obese.

In the US nearly 75% of the population is overweight and almost half are clinically obese. Sounds like "willpower" isn't working for the vast majority of people.

Re: How long til we're all on Ozempic?

#570

Earlier quoted context omitted.

It’s been studied pretty well. Possible effective solutions to the US obesity epidemic are pretty much limited to: 1) Radically alter aspects of food culture, work culture, social policy, and business regulation. 2) Magic pill (/injection) There appears to be no imminent progress on the many parts of #1 that need serious work, so if we want a big turn-around in the next half-century, #2 has suddenly and surprisingly…

> Possible effective solutions to the US obesity epidemic Just wanted to mention that this is not a US problem, and framing it as such won't help find solutions. Even in southeast Asia the rates over obesity are steadily increasing. Europe is already much fatter than southeast Asia. This is a worldwide phenomenon.

I would argue that the US has some fault to why other western nations are getting fatter.

All of the US's worst fast food chains and food products have been exported. In my tiny city a Carl's Jr. Just opened! There is McDonald's, Burger King and Starbucks everywhere. There are also Dunkin donuts in the supermarket as well as oreos. In contrast there arent any Asian or Russian restaurants chains here.

Local foods have become sweeter in order to compete and there are so many local burger restaurants now it's like I have moved to the US.

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