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How long til we're all on Ozempic?

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Re: How long til we're all on Ozempic?

#351

Post by andrewla »

jncfhnb wrote: post #248
andrewla wrote: post #239

I think Ozempic is a treatment of a symptom but not the underlying condition, but unlike many of the posters here, I do not think the underlying condition is "obesity". The below is mostly speculation. Research especially into people with healthy body weight seems to indicate that there is something going on that is causing widespread obesity. That is, there's some sort of environmental "GLP-1 Turbocharger". Maybe it…

You think ozempic is counteracting this mystery force and it is mere unrelated coincidence that it results in eating substantially less?

Yes?

A lizard whose bite makes its prey eat less is crazy but it exists.

A lizard whose bite makes its prey eat more is also crazy, but maybe it exists?

The first lizard is literal, the second lizard is a stand-in for whatever mystery force I am postulating the existence of.

When you look at the historic literature on diet and nutrition from the first half of the century it's like looking into another universe. People are obsessed with getting people to eat more to prevent malnutrition even when food is freely available. Something changed.

Re: How long til we're all on Ozempic?

#352

Post by vessenes »

oremolten wrote: post #206
arcticbull wrote: post #105

Earlier quoted context omitted.

> "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape. Studies show it just doesn't work. There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667. https://www.ncbi.nlm.nih.gov/pmc/…

it's interesting you state "Studies show it just doesn't work." While we are commenting on an article about a drug which makes you feel less hungry, there by "eating less". The drug doesn't make you use more calories, it simply "makes" you EAT LESS. Eating less(calories) than your body uses consistently for duration is literally the only way you can lose weight. (outside of literally losing limbs, or surgery to remov…

There are a number of pathways these drugs hit - dopamine receptors, they slow processing of food, and in tirzepatide's case at least increase insulin response. They're not just small portions in a shot.

I take "Studies show it just doesn't work" to mean "Studies show telling people to eat less and exercise more definitely doesn't work," as opposed to "caloric deficits don't work".

Re: How long til we're all on Ozempic?

#353

Post by squidlogic »

gcr wrote: post #281
paulmist wrote: post #249

Earlier quoted context omitted.

What is a realistic path to this? Being from Europe I visited US last year and was horrified at the quality of your food. You see a lot of documentaries/youtube videos/etc... discussing the problem, but how do you even go about this?

We have good food, but you won't find it on "The Easy Path." The Easy Path is that gentle encouragement to hit up Chipotle for lunch, because it's "right there." The Easy Path says dinner's hard and you've had a long day, so get something simple, like take-out or microwave. The Easy Path is entropy. The Easy Path is self-care over struggle. The Easy Path is simple carbs shown on prominent display in store shelves. Th…

The Easy Path is a meal service like Factor that delivers healthy food directly to your door step.

The Easy Path is signing up for a fitness class on a regular schedule and baking it into your morning routine.

The Easy Path is not buying extra snacks - just don't have them laying around the house for you to eat when you're bored.

The Easy Path is the path of least resistance. However, you have some agency over the environment you create for yourself, so that path of least resistance is to some degree under your control.

Re: How long til we're all on Ozempic?

#354

Post by calculatte »

supportengineer wrote: post #275
logicchains wrote: post #205

Earlier quoted context omitted.

It's funny you say that because just now the US is starting to re-consider water fluoridation: https://www.theguardian.com/us-news/2024/oct/04/fluoridation... . It's also relative uncommon in other developed countries; according to Wikipedia, "Out of a population of about three-quarters of a billion, under 14 million people (approximately 2%) in Europe receive artificially-fluoridated water. Those people are in the U…

The benefits of fluoridation were amazing. I didn't have a single cavity until I was 25 and had moved away from that area to a non-fluoridated area.

Even if that is true, there's no reason to bathe in it, cook with it, water our lawns with it.

And now it's becoming clear that IQ is affected by fluroride https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409983/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285601/ https://www.reuters.com/world/us/epa-must-address-fluoridate...

So how about we keep it out of our drinking water. If you want to put fluoride on your teeth, use fluoridated toothpaste.

Re: How long til we're all on Ozempic?

#355

Post by pixl97 »

rootusrootus wrote: post #10

I'd think it more likely that it'll be one of the next generation drugs, but I do agree with the premise that it will be really common. A few weeks ago I started a low dose of tirzepatide (aka Mounjaro, aka Zepbound) and the side effects are interesting. The biggest negative, which just takes adjustment, is drastically lower stomach capacity. Used to be that two eggs and two pieces of toast was breakfast. Now I bette…

>I might switch to a twice-a-week split dose at some point to ease the peaks and valleys.

If you're willing to shoot up more often it moderates the effects better.

Re: How long til we're all on Ozempic?

#356

Post by soulbadguy »

indiebat wrote: post #311
apsec112 wrote: post #22

Earlier quoted context omitted.

Saying that the cure for obesity is to eat less is like saying that the cure for heroin addiction is to stop using heroin. It's both clearly true, and also useless.

Heroin changes brain chemically, it's (more) serious addiction than obesity, again being a little insensitive to obese people, but they're bad in comparison. And there are degrees of truthfulness & wrongness right! About the point you're making, two generations before you and me, people where fit, more attentive & generally healthy (outside vaccines that prevent diseases now & positive effects due to advancements in…

> About the point you're making, 2 generations before you and me, people where fit, more attentive & generally healthy (outside vaccines that prevent diseases now & positive effects due to advancements in medicine), what changed?

Air pollution, water quality, pestecide, food/produce quality, plastic particule everywhere...

I find this perspective so bizarre.

Whats the most probable in 2 generation of exponentially increasing and barely regulated technological changes : culture has change so dramatically as to change human nature and makes us all lazy... or... something in the environment/food chain is having phisiolical/biological effects...

Re: How long til we're all on Ozempic?

#357

Post by nixosbestos »

rootusrootus wrote: post #10

I'd think it more likely that it'll be one of the next generation drugs, but I do agree with the premise that it will be really common. A few weeks ago I started a low dose of tirzepatide (aka Mounjaro, aka Zepbound) and the side effects are interesting. The biggest negative, which just takes adjustment, is drastically lower stomach capacity. Used to be that two eggs and two pieces of toast was breakfast. Now I bette…

These are the same effects I got from doing OMAD and going gluten free. If I fuck up and eat processed food, the "food brain" comes back, and I start chasing dopamine like a fiend.

I'm a fan of these tools helping people get this insight, because otherwise people just accept that cloud as their normal.

Re: How long til we're all on Ozempic?

#358

Post by jrflowers »

llamaimperative wrote: post #256
gcr wrote: post #229

Earlier quoted context omitted.

If you have an open mind, I'd like to assign you some homework if you like. Take a look around r/zepbound and count the following: 1. Posts from folks who diet+exercise, or who have tried diet/exercise and nothing's worked so they then turned to Zepbound ("excited to hit the gym," "my diet is finally starting to work with Zepbound" and similar) 2. Posts from folks who haven't tried diet/exercise and turned to Zepboun…

GP isn't talking about self-control, they're talking about the fact we've created a system that requires obscene amounts of self-control if you wish to maintain physical health. People in the 50s weren't slimmer because they had ironclad determination to stay such.

> People in the 50s weren't slimmer because they had ironclad determination to stay such.

People in the 50s (in the US) had, among other things, fistfuls of benzedrine.

Edit: here is a link for the skeptical folks https://www.smithsonianmag.com/history/speedy-history-americ...

Re: How long til we're all on Ozempic?

#359

Post by cortesoft »

Uehreka wrote: post #271
farceSpherule wrote: post #237

A lot of people fail to realize that eating healthy and exercising is not enough for a lot of people who fight with their weight their entire lives. Ozempic and Wegovy are game changes and have real, tangible health benefits. One person told me, "No matter how much I eat or exercise, I have been 'hungry' my entire life. That ended when I started taking these drugs."

I gained about 50 pounds the past decade and the past year I’ve been trying to lose it. I weighed myself at the beginning: 205 lbs I started running 30 minutes per day (heartrate training targeting about 140-150), every day, for 10 months. I kept my diet the same as before (though with a protein bar after the run). Weighed myself every week or two, always within a couple pounds of 205. In March I ramped up my runs to…

Its a pretty well known fact that exercise alone (unless you are doing extreme athlete training) is not going to change your weight without a change in diet.

You can get healthier with exercise, but not smaller. That is almost entirely based on diet.

Just think about it; your thirty minutes of running probably burned between 300-500 calories. That one protein bar probably has about 300 calories by itself.

Re: How long til we're all on Ozempic?

#360

Post by pixl97 »

DonnyV wrote: post #303
bryanlarsen wrote: post #262

Earlier quoted context omitted.

> a huge swath of the population will be dealing with issues 30 years form now We've got 20 years of data on this class of drug. Certainly there could be some long term issues that we're not aware of yet, but it's not likely that there are significant issues that affect a large percentage of users after 30 years that didn't affect the small sample of users that have been using it for 20 years or the massive number of…

How much of the data was done independent and how much was done by the same company or companies that benefit from it? We've seen this before. How many decades did people take aspirin thinking it was good for you to take everyday. How many decades did people drink wine thinking it was good for you in small dosage? How many people smoked using it as an appetite suppressant not knowing the long term effects? The list g…

How much data do we have on obesity and the effects of it?
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