Earlier quoted context omitted.
I don't think you can emulate it on a tiny piece of hardware; the smallest full Uxn/Varvara implementation I've seen so far is the GameBoy Advance, which has 384KiB of RAM. On the other hand, you've previously been able to emulate some pretty astonishing things on pretty astonishing hardware. There are a lot of minor things in Uxn and Varvara that make them hard to emulate efficiently. Extensive use of self-modifying…
LE is all i'd ask for. I bet I could get it to run on an 8008 even without that change, but LE would make it easier to emulate :) Stack-based actually helps (registers suck up RAM fast). Self-mod does not matter to emulators. It would for a JIT, but that is a separate story.
If your stacks grew downwards then you could use LE instructions to operate on 16-bit values on the stack. You'd still need to support loading from BE memory into the LE stack but that might not be too bad (two 8-bit operations instead of one 16-bit operation).
The device ports are also specified as BE so in theory you'd need to split those reads/writes up too. However, in almost all cases those are done directly from the stack values so I bet most ROMs would work fine with LE devices and LE stacks. LE devices would only cause issues when someone used 8-bit reads/writes from part of a 16-bit port.