The brain has its own microbiome • Hacker News Board

Re: The brain has its own microbiome

#31

Post by snapcaster » Mon, Oct 07, 2024, 12:11 PM UTC

FollowingTheDao wrote: post #26

FollowingTheDao wrote: post #11

I have a genetic partial immunodeficiency (PNP Deficiency) and I constantly get fungal infections. Living in warm, humid climates is a challenge for me. Reading just the beginning of that article "she experienced chronic pain, digestive problems and a cardiac arrhythmia", well, that is my life. I constantly have minor aspergillosis, and I have some lung nodules from some past fungal infections as well. Keeping the mi…

So, something is weird here, just want to invade this thread and ask HN if there should be a change. I literally have no idea why someone would downvote this comment. But someone did. This does not bother my ego, it bothers my sensibilities. So, maybe we should not allow downvotes unless someone comments on why they thing the comment is negative. No need to do this for upvotes because there is no need to comment on t…

Or maybe your reaction to this downvote is the problem?

Re: The brain has its own microbiome

#32

Post by ajb » Mon, Oct 07, 2024, 12:15 PM UTC

FollowingTheDao wrote: post #26

FollowingTheDao wrote: post #11

I have a genetic partial immunodeficiency (PNP Deficiency) and I constantly get fungal infections. Living in warm, humid climates is a challenge for me. Reading just the beginning of that article "she experienced chronic pain, digestive problems and a cardiac arrhythmia", well, that is my life. I constantly have minor aspergillosis, and I have some lung nodules from some past fungal infections as well. Keeping the mi…

So, something is weird here, just want to invade this thread and ask HN if there should be a change. I literally have no idea why someone would downvote this comment. But someone did. This does not bother my ego, it bothers my sensibilities. So, maybe we should not allow downvotes unless someone comments on why they thing the comment is negative. No need to do this for upvotes because there is no need to comment on t…

You have a point, but often it seems that if a comment got a downvote because some rando took exception to it without a good reason; then the crowd will vote it back up fairly soon. And indeed, your comment is not grey at the time of writing. I personally am not a very consistent upvoter unless either a) the comment was amazing or b) it looks unfairly downvoted.

Re: The brain has its own microbiome

#33

Post by chadcmulligan » Mon, Oct 07, 2024, 12:17 PM UTC

gytisgreitai wrote: post #5

Full article anyone?

its new scientist I wouldn't worry about it. A number of times I've seen articles then looked at the source, they can be fairly exaggerated.

Re: The brain has its own microbiome

#34

Post by foobarbecue » Mon, Oct 07, 2024, 12:18 PM UTC

hinoki wrote: post #7

krageon wrote: post #3

Earlier quoted context omitted.

We can take it one step further: There are microbes everywhere in your body, they matter and they do things. When you take them away or fuck with them too much, weird things start happening. It is I think not a particularly surprising take. But then often it can be valuable to have things that are kind of obvious codified into a paper of some sort so that we no longer have to rely on "but isn't that obvious?" and can…

Is there any evidence (yet?) of an autoimmune disease caused by the immune system accidentally attacking part of the micro-biome?

Great question. Not that I have heard of.

Re: The brain has its own microbiome

#35

Post by hanniabu » Mon, Oct 07, 2024, 12:20 PM UTC

hinoki wrote: post #7

krageon wrote: post #3

Earlier quoted context omitted.

We can take it one step further: There are microbes everywhere in your body, they matter and they do things. When you take them away or fuck with them too much, weird things start happening. It is I think not a particularly surprising take. But then often it can be valuable to have things that are kind of obvious codified into a paper of some sort so that we no longer have to rely on "but isn't that obvious?" and can…

Is there any evidence (yet?) of an autoimmune disease caused by the immune system accidentally attacking part of the micro-biome?

Idk if there's evidence of it but I know many people claim they developed celiac disease after a course of black label antibiotics

Re: The brain has its own microbiome

#36

Post by MailleQuiMaille » Mon, Oct 07, 2024, 12:23 PM UTC

Surprised as how such basic stuff gets "discovered" now and then. For all the toot of science, how come it took us that long to realise such a basic (in appearance at least I'm sure) fact ?

Re: The brain has its own microbiome

#37

Post by foobarbecue » Mon, Oct 07, 2024, 12:24 PM UTC

snapcaster wrote: post #31

FollowingTheDao wrote: post #26

Earlier quoted context omitted.

So, something is weird here, just want to invade this thread and ask HN if there should be a change. I literally have no idea why someone would downvote this comment. But someone did. This does not bother my ego, it bothers my sensibilities. So, maybe we should not allow downvotes unless someone comments on why they thing the comment is negative. No need to do this for upvotes because there is no need to comment on t…

Or maybe your reaction to this downvote is the problem?

Down voting parent because it is entirely unproductive -- combative, with no attempt to explain itself.

Re: The brain has its own microbiome

#38

Post by xattt » Mon, Oct 07, 2024, 12:25 PM UTC

giantg2 wrote: post #23

uLogMicheal wrote: post #2

Next will we find that there is an exchange of microbes between the brain and gut?

Of course. Gut microbes to blood via leaky gut, small enough blood microbes to brain via BBB.

That’s the purpose of the BBB, which breaks down in hypoxia and cell death.

Re: The brain has its own microbiome

#39

Post by foobarbecue » Mon, Oct 07, 2024, 12:26 PM UTC

FollowingTheDao wrote: post #26

FollowingTheDao wrote: post #11

I have a genetic partial immunodeficiency (PNP Deficiency) and I constantly get fungal infections. Living in warm, humid climates is a challenge for me. Reading just the beginning of that article "she experienced chronic pain, digestive problems and a cardiac arrhythmia", well, that is my life. I constantly have minor aspergillosis, and I have some lung nodules from some past fungal infections as well. Keeping the mi…

So, something is weird here, just want to invade this thread and ask HN if there should be a change. I literally have no idea why someone would downvote this comment. But someone did. This does not bother my ego, it bothers my sensibilities. So, maybe we should not allow downvotes unless someone comments on why they thing the comment is negative. No need to do this for upvotes because there is no need to comment on t…

I think sometimes these are accidental. When using HN on mobile, the up/down widget is so tiny that it's very easy to hit down when you mean to hit up.

Re: The brain has its own microbiome

#40

Post by teaearlgraycold » Mon, Oct 07, 2024, 12:28 PM UTC

MailleQuiMaille wrote: post #36

Surprised as how such basic stuff gets "discovered" now and then. For all the toot of science, how come it took us that long to realise such a basic (in appearance at least I'm sure) fact ?

Not quite what you asked, but I know of why another really common set of micro organisms wasn’t noticed. Megaviruses, which rival bacteria in size, were only discovered in the last couple of decades. They’re everywhere. But when people would look for viruses they’d do so specifically by sorting matter in samples by size. So effectively by definition a virus would have to be small. We’d been looking at them under microscopes for over a hundred years but assumed they were inert particles.