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The brain has its own microbiome

newscientist.com

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Re: The brain has its own microbiome

#11

Post by FollowingTheDao »

I have a genetic partial immunodeficiency (PNP Deficiency) and I constantly get fungal infections. Living in warm, humid climates is a challenge for me.

Reading just the beginning of that article "she experienced chronic pain, digestive problems and a cardiac arrhythmia", well, that is my life. I constantly have minor aspergillosis, and I have some lung nodules from some past fungal infections as well.

Keeping the microbiome under control is all about a healthy immune system.

But since my disorder affected my mental state they just labeled me as a psychiatric case and did not look any further, If anyone here is a doctor, please do not give up on psychiatric patients. Thanks.

Interesting case here:

Aspergillosis of the central nervous system in a previously healthy patient that simulated Creutzfeldt–Jakob disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180434/

"He was admitted to the hospital with an occipital headache which he had endured for 2 months. For over 1 and a half months, he had also experienced behavioral disorders and a disruption of higher mental functions. He had retrograde and anterograde amnesia with both echolalia and the presence of visual hallucinations. "

Re: The brain has its own microbiome

#16

Post by Calavar »

hajjf wrote: post #10

Where are we in the hype cycle regarding microbiome? Would it be feasible to launch a startup that leverages the synergy between AI, the blockchain and gut bacteria? I am serious!

It does feel like every organ system and every disease has at least one research group trying to connect it to the microbiome. It's reminiscent of the hype cycle around oxidative stress and antioxidants 20 uears ago. There was a core of solid science there, but in terms of connecting specific diseases to oxidative stress, it seems like the research community has largely moved on.

Re: The brain has its own microbiome

#18

Post by mhaberl »

hajjf wrote: post #10

Where are we in the hype cycle regarding microbiome? Would it be feasible to launch a startup that leverages the synergy between AI, the blockchain and gut bacteria? I am serious!

There is one with the AI and gut bacteria combination: https://www.linkedin.com/company/anibiome/ They recently raised series A.

> Ani Biome uses machine learning models to provide personalized solutions for enhancing gut microbiome function and addressing inflammation, a prevalent factor in age-related chronic ailments.

But they are missing the blockchain component :)

Re: The brain has its own microbiome

#19

Post by mapt »

hajjf wrote: post #10

Where are we in the hype cycle regarding microbiome? Would it be feasible to launch a startup that leverages the synergy between AI, the blockchain and gut bacteria? I am serious!

If you were a nonprofit medical service or a for-profit insurance company, you could do AI analysis of gut microbiome eDNA against electronic health records with potential for significant value if you could get a stool sample every so often.

Re: The brain has its own microbiome

#20

Post by FollowingTheDao »

Calavar wrote: post #16
hajjf wrote: post #10

Where are we in the hype cycle regarding microbiome? Would it be feasible to launch a startup that leverages the synergy between AI, the blockchain and gut bacteria? I am serious!

It does feel like every organ system and every disease has at least one research group trying to connect it to the microbiome. It's reminiscent of the hype cycle around oxidative stress and antioxidants 20 uears ago. There was a core of solid science there, but in terms of connecting specific diseases to oxidative stress, it seems like the research community has largely moved on.

> in terms of connecting specific diseases to oxidative stress, it seems like the research community has largely moved on.

As someone who knows someone at UNC Chapel Hill who was researching this starting about 15 years ago, the research community did not move on, the news just stopped talking/hyping about it.

Here is a recent paper: Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease

https://pubmed.ncbi.nlm.nih.gov/35395415/

It is fundamentally true that oxidative balance is crucial to health, and that nutrients play a large role in maintaining that balance; Manganese (SOD2) zinc/copper (SOD1/SOD3), Selenium/Riboflavin/Pyridoxine (Glutathione).

Deficiencies will not cause one disease, but many different ones, depending on the persons risk.

I think oxidative balance plays a large role in controlling the microbiome.

Nutrition, oxidative stress and intestinal dysbiosis: Influence of diet on gut microbiota in inflammatory bowel diseases

https://pubmed.ncbi.nlm.nih.gov/35395415/

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