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An adult fruit fly brain has been mapped

economist.com

11–20 of 208 posts

Re: An adult fruit fly brain has been mapped

#11

Datahoarder question but can I download the map of the fly?

See the FAQ: https://codex.flywire.ai/faq which leads to the API for access: https://codex.flywire.ai/api/download

You'd need to inspect the paper, the supplementals, and the website closely to determine exactly which files are interesting.

Re: An adult fruit fly brain has been mapped

#12

What does it mean "mapped". Does it mean we know what each nerve/axon does?

It's my (layman) understanding that it's more or less a wiring diagram. Synapse #8217492 connects neuron #27472 and neuron #27865. It's a graph with 140,000 nodes (neurons) and 54.5 million edges (synapses). And then some labels for them like neurotransmitter type, which class of brain operations they're associated with, its size and position in 3D, etc. They have a cool website that lets you browse the data: https:/…

Is the data such that it can be modeled in software?

Re: An adult fruit fly brain has been mapped

#13

It was my understanding that all this connectome-based research was largely a deadend, because it doesnt capture dynamics, nor a vast array of interactions. if you've ever seen neurones being grown (go search YT), you'll see it's a massive gelatinous structure which is highly plastic and highly dynamic. Even in the simplest brains (eg., of elgans), you get 10^x exponential growth in number of neurones and their conne…

From https://news.ycombinator.com/item?id=35877402#35886145 :

> So, to run the same [fMRI, NIRS,] stimulus response activation observation/burn-in again weeks or months later with the same subjects is likely necessary given Representational drift

And isn't there n-ary entanglement?

Re: An adult fruit fly brain has been mapped

#15
"human brains could follow" feels like a few jumps ahead? a fruit fly has on the order of 100k neurons, a human brain has on the order of 100 billion neurons. that's 6 orders of magnitude larger. that's like saying "A map of San Francisco has been completed, the entire solar system could follow!"

Re: An adult fruit fly brain has been mapped

#18
post #15

"human brains could follow" feels like a few jumps ahead? a fruit fly has on the order of 100k neurons, a human brain has on the order of 100 billion neurons. that's 6 orders of magnitude larger. that's like saying "A map of San Francisco has been completed, the entire solar system could follow!"

Well assuming the same density it's "only" 100 times bigger in linear dimensions. Doesn't sound quite as crazy...

Re: An adult fruit fly brain has been mapped

#19
post #16

Are all fruit fry brains the same? Does anyone know what has actually been mapped and why it would generalize from one fruit fly to the next?

I don't think that drosophila are eutelic (https://en.wikipedia.org/wiki/Eutely) so no two flies have precisely the same cells at precisely the same locations (that's true for c. elegans, whose connectome is probably the best studied).

The large-scale architecture will be roughly the same between any two individuals. You would likely need some sort of mapping (like an embedding) to generalize. It's definitely an active area of research.

Re: An adult fruit fly brain has been mapped

#20
post #15

"human brains could follow" feels like a few jumps ahead? a fruit fly has on the order of 100k neurons, a human brain has on the order of 100 billion neurons. that's 6 orders of magnitude larger. that's like saying "A map of San Francisco has been completed, the entire solar system could follow!"

I thought it was intended as more of a pun on questionable displays of human intelligence.
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