Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night • Hacker News Board

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#31

Post by jaggederest » Mon, Sep 23, 2024, 10:09 AM UTC

FollowingTheDao wrote: post #28

lecunn wrote: post #23

Earlier quoted context omitted.

Just curious, but how do you know that you are a "holder of the slow gene"?

Probably though 23andMe and the CYP450 enzyme CYP1A2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212886/

Actually went through fullgenomes.com - they apparently don't offer exome sequencing any more but for under $1200 getting your genome sequenced is interesting.

If you ask anyone who works in genetics, though, they'll advise you never to do it. It can be bad news, but there's virtually no good news there.

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#32

Post by froh » Mon, Sep 23, 2024, 10:23 AM UTC

great! now, has anybody found apps to approximate caffeine contents from bean, roast and prep?

this could be a basis for computation:

How Much Caffeine in Coffee Cup? Effects of Processing Operations, Extraction Methods and Variables

Carla Severini, Antonio Derossi, Ilde Ricci, Anna Giuseppina Fiore and Rossella Caporizzi

Reviewed: 05 April 2017 Published: 21 June 2017

DOI: 10.5772/intechopen.69002

open access:

https://www.intechopen.com/chapters/55623

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#33

Post by bilsbie » Mon, Sep 23, 2024, 10:32 AM UTC

Coffee must have a very different half life in me. Even 400mg in the morning won’t completely leave my system over 24 hours. So it seems to gradually build up and by the fourth day of 400 mg I can’t sleep at all.

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#34

Post by dunk010 » Mon, Sep 23, 2024, 10:33 AM UTC

jaggederest wrote: post #31

FollowingTheDao wrote: post #28

Earlier quoted context omitted.

Probably though 23andMe and the CYP450 enzyme CYP1A2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212886/

Actually went through fullgenomes.com - they apparently don't offer exome sequencing any more but for under $1200 getting your genome sequenced is interesting. If you ask anyone who works in genetics, though, they'll advise you never to do it. It can be bad news, but there's virtually no good news there.

It's useful to have as a resource that you can dip into; for instance to check a specific thing like "how fast do I metabolise caffeine (bad example as youc can get that from a SNV checking service like 23&Me. However, never ever EVER dump your whole genome into a program that will output every match for some potential condition. Now that's not for the reason you might immediately think ("Oh no look at all the bad stuff"), but rather because the databases that tools like this use are pretty chock full of junk where some researcher threw in a reference - along with a few thousand others - to say that their particular piece of research implicates this gene at this poistion with this variant. I've seen it with my own eyes, and a lot of it is very low quality. You therefore need highly curated databases where the genotype-phenotype associations are well-defined and thoroughly researched. You'll spend the rest of your life either trying to prove/disprove every potential false positive, or just worrying yourself needlessly. So, yeah, it's not a bad resource to have if you can be responsible with it.

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#35

Post by bilsbie » Mon, Sep 23, 2024, 10:34 AM UTC

I don’t have a link handy but I was just reading that broccoli can speed up caffeine metabolism!

Someone should do a test.

More broadly we should be researching products to increase caffeine metabolism. It would have a huge market.

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#36

Post by delichon » Mon, Sep 23, 2024, 10:44 AM UTC

I had a >300mg caffeine/day energy drink habit for a few of years. It took around six months to get past the additional fatigue after quiting. There seems to be some long term effect on me way beyond the half life. Does everyone else get past the effects of going cold turkey in a matter of hours?

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#37

Post by hbs18 » Mon, Sep 23, 2024, 10:49 AM UTC

delichon wrote: post #36

I had a >300mg caffeine/day energy drink habit for a few of years. It took around six months to get past the additional fatigue after quiting. There seems to be some long term effect on me way beyond the half life. Does everyone else get past the effects of going cold turkey in a matter of hours?

Would gradually decreasing the amount of caffeine consumed have made quitting the habit easier?

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#38

Post by jessyco » Mon, Sep 23, 2024, 10:51 AM UTC

delichon wrote: post #36

I had a >300mg caffeine/day energy drink habit for a few of years. It took around six months to get past the additional fatigue after quiting. There seems to be some long term effect on me way beyond the half life. Does everyone else get past the effects of going cold turkey in a matter of hours?

Not a chance. The body has to adapt and start producing chemicals naturally again which it hasn't. You'll also have to go through the addiction side effects of the habit which can be hard for your mental health. In my experience it's taken about 2 weeks for my body to adjust and get rid of the side effects... but then again sips coffee I've not stopped for to long.

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#39

Post by FollowingTheDao » Mon, Sep 23, 2024, 11:01 AM UTC

jaggederest wrote: post #31

FollowingTheDao wrote: post #28

Earlier quoted context omitted.

Probably though 23andMe and the CYP450 enzyme CYP1A2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212886/

Actually went through fullgenomes.com - they apparently don't offer exome sequencing any more but for under $1200 getting your genome sequenced is interesting. If you ask anyone who works in genetics, though, they'll advise you never to do it. It can be bad news, but there's virtually no good news there.

I had mine run twice through 23andMe just to make sure they didn’t get something wrong. I tried to get my full genome once but the company screwed me over.

And I take exception to your “no good news”.

I discovered a gene polymorphism that led to the discovery the reason for my immune deficiency and mood disorder.

I found it gave me agency as well since I know that these genes are all risk genes and not fully determinant genes.

Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night

#40

Post by systems_glitch » Mon, Sep 23, 2024, 11:01 AM UTC

delichon wrote: post #36

I had a >300mg caffeine/day energy drink habit for a few of years. It took around six months to get past the additional fatigue after quiting. There seems to be some long term effect on me way beyond the half life. Does everyone else get past the effects of going cold turkey in a matter of hours?

I went cold turkey after developing a facial tic and realizing I was consuming 1000 - 1200 mg of caffeine a day (mostly coffee, French press and canned, with some energy drinks too). I was 100% not aware that caffeine is physically addictive and causes receptor changes in your brain. Aside from withdrawal symptoms (joint aches and pains for me), the fatigue didn't fully go away after several months.

What did "fix" it was bringing it up to my doctor at my yearly checkup -- I explained that my mystery joint pains from a few years ago were almost certainly physical symptoms of caffeine withdrawal. This led to "why in the world were you consuming that much?!" questions and an eventual diagnosis of adult ADHD (likely lifelong and never diagnosed). 10 mg of generic ritalin twice a day and not only is the no-caffeine fatigue gone, but I basically don't tolerate caffeine anymore and have zero desire to consume it. Fortunately the local coffee roaster has a decaf :P I love coffee with or without the caffeine.