Or drink green tea that negates these effects via l-theanine automatically.
Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night
21–30 of 148 posts
Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night
#22Here's the thing: never mind getting to bed, that will happen when you are tired enough. How about sleeping through the night? A different function with different math. My model is caffeine is well-known for having a half-life, from three to six hours depending. That means a geometric fall in effective caffeine in your system after you go to sleep (you don't continue ingesting caffeine in your sleep do you? Sleep-bre…
And there are at least 3 different metabolic rates for caffeine, rapid, standard, and slow. As a holder of the slow gene, none of these calculators work for me since for me caffeine has a ~9 hour half life. Caffeine after about 11 am is a bad plan.
This is interesting.
One thing I am fairly sure about, the amount of caffeine makes a difference to my sleep quality. If I have a single cup of coffee in the morning, no more, then my sleep quality seems not to be impacted. If I have several cups of coffee, only in the morning, I feel great for the morning, very stimulated, but my sleep is impacted. I wake up with a buzzing several times a night and have never been able to understand what is causing the buzzing.
Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night
#23Here's the thing: never mind getting to bed, that will happen when you are tired enough. How about sleeping through the night? A different function with different math. My model is caffeine is well-known for having a half-life, from three to six hours depending. That means a geometric fall in effective caffeine in your system after you go to sleep (you don't continue ingesting caffeine in your sleep do you? Sleep-bre…
And there are at least 3 different metabolic rates for caffeine, rapid, standard, and slow. As a holder of the slow gene, none of these calculators work for me since for me caffeine has a ~9 hour half life. Caffeine after about 11 am is a bad plan.
Just curious, but how do you know that you are a "holder of the slow gene"?
Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night
#24Does this work to assess each individual'd actual caffeine half life? Every individual is metabolizing caffeine at a different rate...
Line 6 of readme.md: Assumptions The script works on some generalized assumptions that would be difficult to take into account.
why read anything when you can just ask the comments and make someone else do the work? /s
Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night
#25This looks like a windows only app, here's another source, that runs on the browser. https://www.gkbrk.com/wiki/caffeine-halflife/.
Not affiliated, I just use it
Also, Smokers metabolise caffeine faster. https://pubmed.ncbi.nlm.nih.gov/657717/
Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night
#26Here's the thing: never mind getting to bed, that will happen when you are tired enough. How about sleeping through the night? A different function with different math. My model is caffeine is well-known for having a half-life, from three to six hours depending. That means a geometric fall in effective caffeine in your system after you go to sleep (you don't continue ingesting caffeine in your sleep do you? Sleep-bre…
And there are at least 3 different metabolic rates for caffeine, rapid, standard, and slow. As a holder of the slow gene, none of these calculators work for me since for me caffeine has a ~9 hour half life. Caffeine after about 11 am is a bad plan.
Try drinking more water. When I drink a lot of water, I feel that I can drink a cup much later in the evening and sleep much better at night. I highly suspect that the water intake and release washes caffeine away with it (e.g. helps with whatever mechanism caffeine is removed be it filtration, chemical, metabolism, etc). There are lots of other benefits to remaining well-hydrated, I wish that I understood this decades ago.
Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night
#27Cool. But to guard your sleep a bit more than just caffeine blood concentration is needed.
Caffeine will influence your sleep schedule by influencing your cicardian clock via its effect on the underlying signaling.
That effect stacks with that of bright light etc, so half-life is not enough.
Rule of thump: 2 espressos 3h before normal bedtime will delay your sleep by ca. 40 minutes even without bright light.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657156/#:~:tex....
Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night
#28Earlier quoted context omitted.
And there are at least 3 different metabolic rates for caffeine, rapid, standard, and slow. As a holder of the slow gene, none of these calculators work for me since for me caffeine has a ~9 hour half life. Caffeine after about 11 am is a bad plan.
Just curious, but how do you know that you are a "holder of the slow gene"?
Probably though 23andMe and the CYP450 enzyme CYP1A2.
Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night
#29Earlier quoted context omitted.
And there are at least 3 different metabolic rates for caffeine, rapid, standard, and slow. As a holder of the slow gene, none of these calculators work for me since for me caffeine has a ~9 hour half life. Caffeine after about 11 am is a bad plan.
Just curious, but how do you know that you are a "holder of the slow gene"?
a) personal experience, also my mom carries it. b) I had my exome sequenced in 2018, and Promethease generated a report from it that showed slow metabolizer in cyp1a2
Re: Coffee Stats – Maximize Caffeine Intake and Get to Bed at Night
#30A note about caffeine and adenosine. What keeps you awake is that adensosine turns into inosine via Adensoine Deaminase (which needs zinc). Inosine ends up inhibiting the GABA receptor[1].
[1]https://link.springer.com/article/10.1007/BF02255859
When I drink caffeine I get mild hallucinations and my blood pressure skyrockets. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421806/