121–130 of 372 posts
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DIY tips please on how to do it What do I need, centrifuges ?, Electrophoresis gel ?, X-RAY machines, Or hand held dna scanning devices like these : https://arstechnica.com/science/2018/01/pocket-sized-dna-rea... ?
https://stackoverflow.blog/2021/12/24/sequencing-your-dna-wi... ~$800 USB dongle (above article was published in 2021 and the price has gone down) plus consumables.
Zero chance I ever give my DNA to one of these companies.
I took an alternate approach: my genome is freely available: https://my.pgp-hms.org/profile/hu80855C When I was sequenced, a bunch of genetic counselors at Illumina analyzed it and said they couldn't find a single gene mutation that was linked to increased risk of disease, which was a surprise to me but is really absence of information rather than information of absence.
Literally just one day after 23andMe presented positive phase 2 clinical results for two anti-cancer drugs: https://therapeutics.23andme.com/news-and-research/ The board of directors of 23andMe just resigned in protest. The CEO, Anne Wojcicki (who's sister Susan died of lung cancer last month, and was the former CEO of YouTube) had tried to low ball take the company private at only $0.40 a share -- a more than 96% dr…
To complete the data, the company is trading at $0.34/share, so while $0.40 is a bit lower than the typical 20% premium (~$0.41), I'm not sure it counts as "lowball". It's a typical premium over market cap. Is there any reason to think the company is worth $4.7B or whatever ($9.30/share)? If so the stock is a steal at its current price and we should all buy lots. But can the market be THAT wrong?
Yes. Historic examples abound of the market being that wrong. People can and have made fortunes by finding those opportunities.
Which is different from is the market that wrong in this case?
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Most of them are minor ideas like the ones I just copy/pasted below. But sometimes they are longer like this one: https://hub.scroll.pub/applecard/applecard.pdf ----- Nope, we don't have one yet though it would be a good idea. I'm looping in Joe for this. Thanks for the nudge! Nathan Co-founder & CTO Help: www.airbnb.com/help Recent press: Washington Post http://bit.ly/KkEzT On Mon, Oct 12, 2009 at 11:12 AM, Breck Yu…
wow altman hired jacob bc of your email?
he (or his office/AGI reply bot) always humors me into at least believing he's listening ;)
(he has also always generously provided me with great guidance many times over the years, like when he advised me to take the MSFT offer we got in 2014, when I was on the fence, which turned out to be the right move 110%)
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My oldest brother did so I'm already screwed
Can even one single person here articulate their specific fears of using 23andme, or is it all FUD?
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On the topic of laughability, I would propose that "invoking a dead stranger's name in a self-significant ritual" is absurd to do, and also absurd to be offended by. I hereby grant permission for my name to be invoked in all rituals, sacred and profane, by all current and future living persons. And I'll laugh at you in advance.
Que sera, sera Whatever will be, will be The future's not ours to see Que sera, sera
Zero chance I ever give my DNA to one of these companies.
Why? It's just a record of a group of letters, not your soul. I upload my dna records everywhere I can. Sure I had some surprises but in general I benefit from those services.
What the Nazis would have done if they had gotten their fingers onto such a ddatabase is anybodies guess.
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Was the plan all the time to go B2B (drug development) and they just used B2C (selling SNP kits) to hoard samples? Even considering all FDA limitations, I cannot understand how bad their genetic risk scores are. They have talent, they have lots of customers and data. This is a position other companies, like deCODE, would have killed to be in.
Anne's plan from the very beginning was to capitalize on the value of the human genome in drug development and medical testing. Frankly everything you need to know about the idea behind the company before its various pitfalls and pivots is here (2007): https://web.archive.org/web/20140312001152/http://www.wired.... (sorry, it takes a while to load but wired has killed most of their long-term links) IMHO she and Avey…