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Researchers find Alzheimer's-like brain changes in long Covid patients

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101–110 of 197 posts

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#101

I had strange symptoms post-Covid infection - my ability to recognize faces was very distorted and it seemed like everyone was familiar to me. It was like everyone I saw was an old high school acquaintance or maybe a celebrity, and I would get anxious because I didn't remember their name.

there was publications about viruses "causing the host to be more outgoing/in public" in the lead-up to the part of the disease where you're laid up with fluids leaking out of every orifice. I'm fairly certain some flu and iirc sars-ncov-2 were found to display this secondary (or tertiary) effect. So you "catch" a flu. Before you know you've caught it, suddenly you want to go out to dinner, or go to a meetup of frien…

"hey... Don't I know you from somewhere?" will become an even worse pickup line when it means the person probably has Covid

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#102

Alz is brain inflammatory response to viruses (among other foreing detritus) that got past the blood-brain barrier, so I'm not surprised.

Not fully known but increasing evidence. Pretty stunning result is the discontinuity in all causes dementia for NHS seniors in Wales with the week of birth as the discontinuity point (week of birth is cutoff qualifier for a shingles vaccine)

That was really interesting, I saw it earlier while logged out and just wanted to say thanks for pointing that out.

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#103

Earlier quoted context omitted.

it's stigmatized, has an overwhelmingly complex etiology and no clear empirical signature. i think for the most part people just don't think it's real

After acquiring a bad case of mononucleosis at 18, I acquired CFS which lasted a number of years and severely impacted my ability to focus and make meaningful progress for extended periods of time, and this worsened my depression and anxiety, which exacerbated the problem in a positive feedback loop. Everyone in my life disregarded me or didn't understand the severity of what I was dealing with. Looking back, returni…

I hesitate to ask but have you been checked for Multiple Sclerosis.

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#104
post #81

Earlier quoted context omitted.

Not really, since the survey paper notes that the EEG pathologies were detected in 69-96% of patients, including children. It is not plausible to propose that 69-96% of patients, including children, had undetected brain disorders and that was the direction of causality.

That’d only be true if the study population was a random sample of the general population. If they’re only testing people with symptoms, the causality could easily go either way.

The U.K. BioBank study should put this to rest: https://www.nature.com/articles/s41586-022-04569-5

These are participants whose health is being followed long term. They had brain scans before and after COVID, and abnormalities were detected in the scans post-COVID.

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#105

Earlier quoted context omitted.

All of this has been true for over half a century. The problem is that the direction of improvement in lives has changed. Compare today to the 90s and there’s very little reason to believe that today is better than the 90s in a developed country. What’s frustrating is that we have MORE tools to be in a much better shape right now. We have things available to us today that people wouldn’t have dreamt of in the 90s, in…

I disagree. Reagan's plans, including legitimizing stock buybacks which were previously taboo stock manipulation, 'starving the beast' where a political party was willing to weaponize making the US government worse in order to achieve their ends, etc. are what is responsible for today's worsening environment. You are conflating current technical change with the results of decades olds political policies.

It certainly feels to me that we're simply at the logical end-ish point of 40 years of neoclassical policies that have encouraged the dismantling of society.

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#106
post #96

ME/CFS is seriously underinvested. I don't really understand why, any drug that makes a noticeable difference here will be a guaranteed money printer. There are millions of people suffering total disability, many in developed countries that have well funded medical insurance. Compare that to depression (which it only superficially resembles): many SSRIs, SNRIs, multiple "schools" of psychotherapy, neuroleptics, lithi…

You can probably take a low dose of adderall to alleviate atleast the symptoms.

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#107

Alz is brain inflammatory response to viruses (among other foreing detritus) that got past the blood-brain barrier, so I'm not surprised.

Not fully known but increasing evidence. Pretty stunning result is the discontinuity in all causes dementia for NHS seniors in Wales with the week of birth as the discontinuity point (week of birth is cutoff qualifier for a shingles vaccine)

I don’t understand. What do you mean by week of birth as the discontinuity point?

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#108

I thought I was depressed, but recently realised that I’m actually feeling off because of long COVID symptoms. The brain fog is pretty much constant, and I’m definitely more forgetful and confused than I used to be. There are some cardiac symptoms as well, but those interfere less with my day to day. I’d love to find a way out of this state, but it seems that my doctor doesn’t keep up with the latest research, and do…

I have a similar experience, albeit with a different set of symptoms. I've been active and athletic all my life, never a problem with my blood pressure, after Covid I now permanently have high blood pressure and need to treat for it. All the doctors I've seen tell me that no, Covid doesn't do that, even though there's a clear cut line of before and after.

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#109
post #96

ME/CFS is seriously underinvested. I don't really understand why, any drug that makes a noticeable difference here will be a guaranteed money printer. There are millions of people suffering total disability, many in developed countries that have well funded medical insurance. Compare that to depression (which it only superficially resembles): many SSRIs, SNRIs, multiple "schools" of psychotherapy, neuroleptics, lithi…

You can probably take a low dose of adderall to alleviate atleast the symptoms.

I suggested that once, but was down voted by resident HN Medical Experts LOL

The irony of warning not to take medical advice on HN, and then proceeding to offer alternative medical advice...

This, despite the fact that Doctors do actually prescribe stimulants for CFS.

Re: Researchers find Alzheimer's-like brain changes in long Covid patients

#110
post #95

Earlier quoted context omitted.

It's quite possible that it's environmental suppression of immunity, aging and/or degradation of the blood brain barrier that permits the viruses to make their way topside. There's some evidence that the amyloid plaques actually exhibit antimicrobial activity and may be an immune response to infection. [1] In my unsubstantiated opinion it's likely to be herpesviridae that make their way to the brain due to their affi…

> It also explains why acyclovir and valacyclovir dramatically reduces the risk of developing dementia. Sounds fascinating, where could one read more about this? I don’t think I’ve come across this before.

Here's a couple of studies.

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882534/

[2] https://alzres.biomedcentral.com/articles/10.1186/s13195-021...

And here's a clinical trial that's been running since 2018, scheduled for conclusion at EOY 2024.

[3] https://clinicaltrials.gov/study/NCT03282916

This is a very in-depth hypothesis paper that explains more.

[4] https://core.ac.uk/download/544294788.pdf

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