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WTH Is Cerebrolysin, Actually?

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Re: WTH Is Cerebrolysin, Actually?

#51

Post by gwern »

_nalply wrote: post #20
rdtsc wrote: post #2

> Pigs were a fortuitous choice due to the fact that they are especially resistant to prion disease Prions is the first thing that came to mind after reading the description. I had not idea pigs are resistant to it. TIL.

Perhaps. I wouldn't believe any statements that I learnt today before some research validating it, and even then only give a measure of confidency. Here I did that for you: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510857/ I trust NIH so my confidence that they write corresponds to truth is high even for the scientific interpretation of truth. And that's what they wrote: > Pigs were considered prion resistant as…

> So, no, pigs are not resistant but more resistant than cattle and humans.

...what does 'resistant' mean if not 'less likely to be infected than something else is'? Is it not inherently a comparison?

Re: WTH Is Cerebrolysin, Actually?

#52

Post by rdtsc »

_nalply wrote: post #20
rdtsc wrote: post #2

> Pigs were a fortuitous choice due to the fact that they are especially resistant to prion disease Prions is the first thing that came to mind after reading the description. I had not idea pigs are resistant to it. TIL.

Perhaps. I wouldn't believe any statements that I learnt today before some research validating it, and even then only give a measure of confidency. Here I did that for you: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510857/ I trust NIH so my confidence that they write corresponds to truth is high even for the scientific interpretation of truth. And that's what they wrote: > Pigs were considered prion resistant as…

> So, no, pigs are not resistant but more resistant than cattle and humans.

That's what I meant, sorry for the confusion. I didn't mean that they are 100% immune just that they are more resistant. Perhaps that's the difference between a medical "resistance" vs the colloquial meaning.

I would definitely not jump into drinking raw pig brain smoothies either way and won't advise anyone else to do it either.

Re: WTH Is Cerebrolysin, Actually?

#53

Post by rdtsc »

gwern wrote: post #51
_nalply wrote: post #20

Earlier quoted context omitted.

Perhaps. I wouldn't believe any statements that I learnt today before some research validating it, and even then only give a measure of confidency. Here I did that for you: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510857/ I trust NIH so my confidence that they write corresponds to truth is high even for the scientific interpretation of truth. And that's what they wrote: > Pigs were considered prion resistant as…

> So, no, pigs are not resistant but more resistant than cattle and humans. ...what does 'resistant' mean if not 'less likely to be infected than something else is'? Is it not inherently a comparison?

Right, that's exactly what I (GP) took it to mean. Maybe there is medical "resistance" term to mean 100% immunity from something, but I meant it in a pedestrian sense that pigs are considered _more_ resistant than say cows, when I thought they'd be about the same risk for both.

Re: WTH Is Cerebrolysin, Actually?

#54

Post by chriscappuccio »

9dev wrote: post #12
knodi123 wrote: post #4

Okay, so this miracle drug isn't a miracle either. Which miracle drug is?!?! I'm not asking sarcastically or ironically- I'm sincerely begging for miracles. Anyone??

Not the answer you’re looking for, but mRNA vaccines as used for COVID are nothing short of a miracle. The bioengineering behind them, the logistics of it all—it was incredible.

An incredible waste you mean?

Re: WTH Is Cerebrolysin, Actually?

#55

Post by RGamma »

emsign wrote: post #15

> Ever Pharma’s explanation of how the putative peptides in Cerebrolyin cross the blood-brain barrier does not make sense and flies in the face of scientific research which shows that most peptides do not cross the blood-brain barrier It can be considered a benefit from a manufacturer's pov that their product doesn't work. If it did their customers would smarten up and stop buying it. Anyway this looks like your typi…

Presumably users that inform themselves wouldn't take something that's approximately named "brain dissolvent" anyway.

Re: WTH Is Cerebrolysin, Actually?

#56

Post by throwaway87483 »

Loughla wrote: post #46
A_D_E_P_T wrote: post #17

"“nootropics” users be like: develop never-before-seen prion diseases from Belarusian nootropics made from centrifuged pig brains that you take intravenously but it was all worth it to accomplish great things like posting on an internet messageboard about nootropics" - The Mighty Hakan

I got into nootropics to help me sleep and try to learn how to lucid dream. I got out of nootropics because anything that can make you lucid dream must have some kind of impact on your brain, and the ENTIRE culture of nootropics is based on being more productive at work (at least the forums I was on). It was kind of gross, to be honest. Put these chemicals in your body so you can focus x% more at your job. No thank y…

Not the "entire" community, the places I spent time on years ago were focused exclusively on improved sleep efficiency, if there is such a thing.

I used piracetam for a few months and functioned well on six hours of sleep per day (the norm is 1.5x that). Remembered dreams pretty well too (I very rarely remember them before or after that period).

It also greatly reduced the effects of alcohol intoxication, but that was more of a downside (strip ethanol of its effects on the mind and you get pure poison).

The were no other noticeable effects, and I stopped taking it because dosages were measured in hundreds of milligrams and I was worried about load on the kidneys.

Re: WTH Is Cerebrolysin, Actually?

#57

Post by pshirshov »

Well, I've been having daily injections between age 4 and 8. Together with ATP and B1-B6-B12 mix.

Don't think it made any difference, either positive or negative. The doctors thought it did, but I was misdiagnosed and as I learned later my EEG dynamics perfectly followed my real condition (which is expected to show huge improvement in EEGs with age starting around 6/7).

My EEGs are still bad, but not as remarkably bad as they were when I was a kid.

At least my family didn't pay for this questionable stuff, it was a free prescription.

Re: WTH Is Cerebrolysin, Actually?

#58

Post by pshirshov »

kalium-xyz wrote: post #49

In using cerebrolysin I've always assumed that if it is a placebo the rituals and concepts behind it make it a very good placebo. It has a lot of "medical" potency to it because the idea of injecting pig brain "just makes sense". Also I really enjoyed my vacation to eastern Europe to acquire a stash of it. For its clinical validity I do recall that it passed some clinical trails which I'd need to look up again howeve…

Oh well, my doctors thought it "cured" me, but I was misdiagnosed.

Re: WTH Is Cerebrolysin, Actually?

#59

Post by metta2uall »

rdtsc wrote: post #2

> Pigs were a fortuitous choice due to the fact that they are especially resistant to prion disease Prions is the first thing that came to mind after reading the description. I had not idea pigs are resistant to it. TIL.

Well, before HIV came along it was thought that humans were quite resistant to retroviruses...
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