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Jake Seliger has died

marginalrevolution.com

131–140 of 220 posts

Re: Jake Seliger has died

#131

Jake was strong. He was so prolific throughout his death process. Truly an inspration, especially to those dying of this disease. It is a terrible disease. I would not wish it on my worst enemy. The horror, pain and lethargy that you experience... Having chunks of your body cut out periodically... Slowly dying from the inside out... Watching your loved ones fall apart... I can barely put into words how difficult it i…

And yet… an invaluable opportunity to say goodbye and "get affairs in order". The suffering for all affected, I completely agree, I would not want anyone to go through. But compared to a recent bereavement I experienced where this person just did not come home, having died suddenly, unexpectedly, tragically alone and unseen. Would that I could choose, I think I would like the notice, despite the downsides. Love to all dealing with grief.

Re: Jake Seliger has died

#132

This is Jake’s sister. He was reading and replying to as much as he could up until the end. He loved this community and would in turn be touched by this entire thread. Thank you all who supported him and read and shared his writing. He said it was bittersweet to go out on top.

I am deeply sorry. <3

Re: Jake Seliger has died

#133
post #110

Earlier quoted context omitted.

I agree with you in spirit but would suggest that pushing for more funding of schools, universities, basic research, and applied research is something that we should all be doing. Imagine if all the smart people tried to cure cancer instead of working in Wall Street and Adtech

Think about how difficult it is to make a significant contribution in your particular field of expertise that is not about to be done right now anyway because the time is right. Very difficult indeed. It is the same with cancer research. Not saying the world can‘t be better, but science cannot be done faster, probably.

> Think about how difficult it is to make a significant contribution in your particular field of expertise that is not about to be done right now anyway because the time is right.

I independently reinvented my entire field of research by accident, because I didn't know it existed; and I'm pretty sure I did a better job. There are a few puzzle pieces and key insights it probably would've taken me a few years (or decades) to discover, without which I couldn't demonstrate (or, if I'm being honest, know) the immense superiority of my approach, but I'm pretty sure the majority of the field is obsoleted by the ideas I've had.

Oh, look at me, I'm so clever… right? Good guess, but actually no. When I ask the right questions to my peers (outside the field), they usually propose a similar approach. (The main differences can be attributed to the fact I've thought about this for years, and they've thought about it for minutes: a few of the obvious things don't work, but then things get elegant when you replace them with ones that do.)

That must mean the time's right, then? I did suspect it was this… until I found a few dozen publications by a widely-respected expert, from half a century ago, talking about a (slightly underdeveloped, idiosyncratic) version of the approach like it was common sense, remarking that people were a lot more receptive to this idea than they used to be, but still it was not being adopted.

A minor application of this approach to a different field would completely revolutionise it (even moreso than it does my field). I briefly fantasised about doing that, before dismissing as "something to investigate later" (i.e. "a childish fantasy I haven't found the holes in yet"). But not only does that application work, it was implemented and trialled. The results were published 26 years ago, in a paper that concludes by confusedly asking why nobody was doing this. After reading the paper (which I found completely by accident while looking for something else), I felt much the same way. (Still nobody is doing it, in case you're wondering. It's been cited six times – once in its field, two years after publication, and five times in other fields in papers where it isn't really relevant.)

In physics, parts of chemistry, and parts of mathematics, there is room for revolution. I'm not sure any of the softer fields (counting mathematics qua philosophy as soft) are particularly good at being revolutionised. (Economics is particularly bad: nearly every economist knows that economics is wrong, and yet it persists.) And it's not because new ideas are slow to be adopted: at least 10% of my field's practitioners dropped everything to try to solve its Hard Problems with LLMs. (Those I know, I talked out of this, by describing – with non-rigorous theoretical arguments – what they would find. After years of work, the best result I've seen is only slightly better than the bound I predicted.)

I'm sure there's some way to solve this problem, but I don't know it. I wouldn't be surprised if the solution has been identified, written down, published, forgotten, independently reinvented, tested, found to work, published again, ignored…

I don't say this to cast aspersions on science, or the academic system; nor to blame people or institutions for their failings. This problem is well-known. It's not a matter of people being stuck in their ways: if anything, academics are too credulous, too willing to believe that things work which don't. But I don't think adjusting the "credulity" dial, or the "speed" dial, or the "try novel approaches" dial, is a solution. Science, as it stands, cannot be done faster, because the system doesn't know how.

All I'm saying is, watch out for this. Support people who think they have a better way, check the literature for interesting things (and then confirm them, if you can). Question not whether your current approaches are good, but what they actually do – and ask whether that is really what you want to be doing, or a proxy goal that everybody's lost sight of.

And if you find yourself along with your peers, dismissing something out-of-hand without having tried it, maybe don't lend your voice to the snubbing crowd. Maybe it's bogus, maybe its proponents are wrong about its merits, but it might have merits. We can't afford not to know.

Re: Jake Seliger has died

#134
post #20

Earlier quoted context omitted.

I've experienced this from both sides. First with my father who was dying of cancer and was informed that while some promising treatments were in trials, he was not eligible. Balancing potential harm from unapproved drugs vs. certain death within 12 months feels like an easy task. On the other side, my wife worked for a mid-sized pharma in the past. After several rounds of trials that each cost tens of millions of do…

Part of the harm is in people no longer trusting drugs. We're very fortunate to be able to get prescribed a drug and have certainty the risk-reward tradeoffs have been evaluated to extreme depth by experts far more equipped than we are.

You are past of the reason the world is a worse place than it could be. Without people like you defending excessive caution as good for the PR of drug regulatory agencies millions of people who are dead would be alive, possibly tens of millions.

Re: Jake Seliger has died

#135

Jake's wife on FDA deregulation https://bessstillman.substack.com/p/the-drugs-killing-dying-...

May Jake rest in peace and may his memory be a blessing to his wife and daughter. Their views on clinical trials were understandable given the circumstances. Those regulations were written in blood, miscarriage/birth defects, autoimmune conditions, genetic damage, and other horrors. This is a complicated ethical topic because clinical trials can harm patients and families of patients as much as they can help, and som…

May you be treated as a free man and not the slave you wish others to be treated as.

Re: Jake Seliger has died

#136

Jake posted as jseliger on HN: https://news.ycombinator.com/user?id=jseliger He blogged at https://jakeseliger.com/ >, and numerous of his blog articles were submitted to HN: https://news.ycombinator.com/from?site=jakeseliger.com >. That includes numerous topics, over the past year or so his experience with cancer, often concerning frustrations with the process and mechanism. His essay on agenticness especially strik…

In an August 2023 post about regrets, https://jakeseliger.com/2023/08/12/regrets/ , his last regret is: * Not looking into that thing on my tongue in July 2022, when I first noticed it, but that is very specific to me and probably not generalizable. In https://jakeseliger.com/2024/05/16/the-financial-costs-of-he... , he mentions "...I got a partial glossectomy in Oct. 2022. Mine had some high-risk features, but I was…

I'm interested in his vague comments about age and how saying age is just a number is coping. Do you know what he might be referring to in his life, or of any posts he's made where he talks about that sort of thing?

Re: Jake Seliger has died

#137

This is Jake’s sister. He was reading and replying to as much as he could up until the end. He loved this community and would in turn be touched by this entire thread. Thank you all who supported him and read and shared his writing. He said it was bittersweet to go out on top.

My deepest condolences.

Much strength to you.

Re: Jake Seliger has died

#138

The craziest thing to me is he was still posting up to the very end. I've seen this multiple times in end-stage cancers, my grandfather's pancreatic cancer, he seemed "fine" (other than looking incredibly sick) til the last ~12 hours or so - he was even doing some yard work the day or two before he died. He knew the entire time how much time was left, too. I don't know why I find this so crazy, other than I hope I ne…

It's very strange - some people are lucid and mobile up until nearly the end, and others are 'out of it' for a long time. My mother was mostly delirious and bedridden for the entire last month of her life before dying from cancer.

I suppose if the person is able to find peace with what's happening, then maybe it's better to be lucid, but for others, maybe being 'out of it' is a blessing.

Re: Jake Seliger has died

#139

This is Jake’s sister. He was reading and replying to as much as he could up until the end. He loved this community and would in turn be touched by this entire thread. Thank you all who supported him and read and shared his writing. He said it was bittersweet to go out on top.

This is heartbreaking, my sincere condolences.

Re: Jake Seliger has died

#140

Earlier quoted context omitted.

In an August 2023 post about regrets, https://jakeseliger.com/2023/08/12/regrets/ , his last regret is: * Not looking into that thing on my tongue in July 2022, when I first noticed it, but that is very specific to me and probably not generalizable. In https://jakeseliger.com/2024/05/16/the-financial-costs-of-he... , he mentions "...I got a partial glossectomy in Oct. 2022. Mine had some high-risk features, but I was…

Cancer is insidious in all kinds of ways. One in particular is that insight into the current and possible state(s) of a tumor are are really difficult to assess. With all our current imaging and testing capabilities, the human body is still largely a black box. Especially after multiple surgeries, distinguishing new tumour growth from scar and necrotic tissues is difficult. And ... for suitably aggressive tumours, ev…

My dad discovered he had a very large solid tumor (a form of soft tissue sarcoma) in 2022 and due to the lack of solid data or population size no oncologist could even give a hunch as to the growth rate. Whether it had been developing slowly for a decade before it finally became symptomatic over a few months, or the terrifying possibility it was extremely fast growing during the year or so he began to notice symptoms which suddenly emerged and then steadily got worse.

Due to lack of evidence for chemo having any benefit for his cancer with devastating impact on quality of life he was instead put into several months of proton radiation therapy, a Keytruda clinical trial, and then surgery all within about 6 months. After about 7 hours into surgery we got a call from the lead surgeon who told us they were unable to get clean margins due to proximity to the bone but spent an extra several hours removing all visible cancerous which was the best they could do before they had to hand it over to the reconstructive surgeon. That was a horrible gut punch and I can still picture the expressions on my brother and mother's face as we processed what we were hearing.

He survived the surgery, recovered impressively quickly, but we were all terrified waiting for the first 3 month follow up scan expecting the worse given the lack of margins and potential of being extremely fast growing. But it was clean, and so was the next 3 month, and he's now through his 7th or so clean scan I believe.

I had read so much about survival rates but the data for his specific cancer was all so poor plus confounded by his tumor being huge (data says that's very bad) but no systemic spread or to adjacent organs (data says that's very good), no clean margins (bad) but no remaining tumor tissue (less bad).

Eventually I realized all the time I spent digging through PubMed for any scrap of a data point hadn't actually given me any insight, reassurance or had any predictive value whatsoever. Which was tough to accept given how my brain is wired. So all I can really do now is be grateful for the extra time he's already had and the possibility that seemed so unlikely pre-surgery that he may even have many more, but the future will always be unknowable either way and not worth obsessing about.

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