One of the most interesting drives in my life was Chile from the island of Chiloe to the Tatio Geysers in the Atacama. Just so many different climate zones, and all in
relatively close proximity.
Chiloe and Puerto Montt were damp, cold, and fog-shrouded in Summer (Jan-Feb), very similar to parts of the coastal pacific northwest.
The area to its north, centered around the German-influenced town of Valdivia, was California-like. Very temperate in Summer, and very green. Lots of pastures and rivers.
The region becomes progressively more "Mediterranean" as you move further north; one gradually sees fewer pastures and woodlands, more vineyards, olive trees, and fruit orchards. Santiago is on the far northern end of this Mediterranean zone. The great wine regions are generally to the south and west of that capital city.
A few hours north of Santiago and all is desert -- but it's a fairly live desert, with all sorts of succulent plants and many types of flower. Most of the road traffic in these parts comes from copper miners and their work trucks.
Continue north and you're in a dry, mostly empty, moonscape. Antofagasta and Calama are nice enough towns, though, and the interesting drive from the former to the latter takes just two hours but sees you rise from sea level to +2000m. It's such a gentle and relentless slope that you barely notice it. Nothing at all like driving in the Alps.
I broke something in my rental car when I continued to the geysers at +4000m, but it was worth it.