Live data from Hacker News

Supreme Court blocks controversial Purdue Pharma opioid settlement

washingtonpost.com

451–460 of 691 posts

Re: Supreme Court blocks controversial Purdue Pharma opioid settlement

#451

Pound for pound, the Sacklers probably did more damage to America than any other drug dealers in history. More damage than any serial killer or mass shooter. In my mind they should be considered public enemies 1 through N. I sincerely hope they face civil and criminal liabilities for what they’ve done.

I’d argue it’s the opposite. Look at what’s happened since Oxycontin was heavily regulated. Opioid deaths in America have exploded by an order of magnitude. There’s a direct correlation between higher regulation of OxyContin and opioid deaths in the U.S. The Sacklers have done illegal stuff. Misrepresenting the addictiveness of their drugs (well, it was immoral and wrong…it’s not clear how illegal it was). But it’s q…

> But it’s quite clear that America had a parallel opioid crisis going on

I don’t think that’s really the case. What happened here was that peddling oxy, created the excess demand that is now met by illicit sources that cause more deaths now that oxy is regulated. But what you’re missing in your understanding is that without oxy, demand wouldn’t exist in the first place. And that’s the harm everyone is talking about.

You’re talking about the aftermath of the problem. Parent is talking about the root cause.

Re: Supreme Court blocks controversial Purdue Pharma opioid settlement

#452
post #436

Earlier quoted context omitted.

> That last thing was their crime Taboos are bullshit. Either something is a clearly articulated, written, rule with an enforcement mechanism, or it's fair game. Prescribing doctors are responsible for the opioid epidemic. Doctors failed in their duty of care to patients. Doctors massively overprescribed, failed to track their patient's medication usage, and failed to spot addictive behaviour. Why aren't we holding t…

> Prescribing doctors are responsible for the opioid epidemic. Doctors failed in their duty of care to patients. Doctors failed to track their patient's medication usage, and failed to spot addictive behaviour. Why aren't we holding them responsible? Simply because that's hard to do? This is a nice idea, but most Oxycontin is not prescribed by someone's doctor (it is prescribed by a doctor, but it is power-law distri…

The on-ramp from minor pain or surgery; to a massive, blindly-renewed, over-prescription of Oxy; to an opioid addiction that spirals into street drugs is still mediated by doctors. Until these doctors start losing their licenses for their clear and obvious breaches in their duty of care, this on-ramp will remain open.

> a small number of doctors in the country at any given time that prescribe almost all of the supply

The fact that medical boards allow these doctors to retain their licenses is the core of the issue.

> we already do and always have

I am only aware of a handful of the most obvious, blatant, and egregious pill mill operators being prosecuted. Regular doctors who simply cannot be fucked to care for their patients, and prescribe them pills so they leave their office, have yet to be held accountable.

Re: Supreme Court blocks controversial Purdue Pharma opioid settlement

#453

Earlier quoted context omitted.

No, my question is about how people judge our opioid status quo: a medical system that prescribes addictive opioids for routine and low-grade pain.

I just wonder why random people would know better about this than your highly educated providers. Go ahead and ask. You can say those exact words. They will give better answers! If you want a poll, this court case was a poll. A majority of victims who had ample time to participate in litigation agreed to the settlement terms. They told you that addiction is bad, the new Purdue would help, and that money from its owne…

> I just wonder why random people would know better about this than your highly educated providers. Go ahead and ask. You can say those exact words. They will give better answers!

Are you sure they'll give "better answers" when they're the ones prescribing like that?

Re: Supreme Court blocks controversial Purdue Pharma opioid settlement

#455

Earlier quoted context omitted.

Sure, OxyContin is better than Fentanyl, and banning Oxy can push people to way more dangerous opioids. But before painting Purdue as a hero of the people, let’s remember that million of people were pushed to opioids through Oxy when they shouldn’t have in the first place. Purdue played a big part in creating the epidemic in the first place. People that are now pushed to harder drugs because of an addiction they got…

It's the same shit practically all the way back to opium wars. Always the drug dealers fault. I blame the patient. We've known opiates were bad since at least the 1800s, and really longer than that. What the doc said was just what they needed to hear to lie to themselves, but this is taught in every highschool.

> I blame the patient. We've known opiates were bad since at least the 1800s, and really longer than that.

As a reminder, Oxy was heavily marketed, (to doctors!) as a "not bad" opioid. As in, not as addictive, not as problematic, and something that can be prescribed more easily and with less worries.

If a doctor comes up and tell you "don't worry about this one, it isn't addictive like the others", and you are in a ton of pain at the time, you are going to thank modern medicine for its new miracle pain drug and accept the prescription.

> but this is taught in every highschool.

And as another reminder, most schools, until recently, just taught that "drugs are bad" and kind of left it at that. They exaggerated some of the down sides, and didn't mention any of the positive experiences.

IMHO South Park actually did the world's best anti pot ad -

"Well, Stan, the truth is marijuana probably isn't gonna make you kill people, and it most likely isn't gonna fund terrorism, but… well, son, pot makes you feel fine with being bored. And it's when you're bored that you should be learning some new skill or discovering some new science or being creative. If you smoke pot you may grow up to find out that you aren't good at anything."

-

And IMHO messages like that are more useful than what kids are being told.

There is also the social contract side of things - Since around 1950s, if people worked hard they things in return from society: A stable job, a house, the opportunity to raise a family. That social contract is shot to shit, and so it should be no surprise that more and more people are choosing to drop out of society via drugs/games/apathy.

Re: Supreme Court blocks controversial Purdue Pharma opioid settlement

#456

Pound for pound, the Sacklers probably did more damage to America than any other drug dealers in history. More damage than any serial killer or mass shooter. In my mind they should be considered public enemies 1 through N. I sincerely hope they face civil and criminal liabilities for what they’ve done.

I’d argue it’s the opposite. Look at what’s happened since Oxycontin was heavily regulated. Opioid deaths in America have exploded by an order of magnitude. There’s a direct correlation between higher regulation of OxyContin and opioid deaths in the U.S. The Sacklers have done illegal stuff. Misrepresenting the addictiveness of their drugs (well, it was immoral and wrong…it’s not clear how illegal it was). But it’s q…

morally: providing more of something that has no societal good is not commendable.

logically: this argument isn't sound at all. looking at what happened since Oxycontin was regulated is not a proper counterfactual. you would have to look at a universe in which it was never introduced to begin with

Re: Supreme Court blocks controversial Purdue Pharma opioid settlement

#457
post #216

Earlier quoted context omitted.

Well, it is. The victims had a settlement agreement worth billions of dollars, which the Sackler family was going to willingly provide in exchange for legal protections. Now that legal protections are off the table, it is very unlikely that any new settlement will be as generous, and in fact quite unlikely that any settlement will be achieved at all.

But also very likely that the case will go to court and the damages will be substantially higher.

Victory is not guaranteed, and even if the victims do win, going to court takes a lot of time and costs a lot of money. The victims agreed to the settlement because they preferred that option to going to court.

Re: Supreme Court blocks controversial Purdue Pharma opioid settlement

#458

Earlier quoted context omitted.

And honestly, while we like to lump them into "conservative" and "liberal" camps for simplicity, it's easy to get the correlation wrong. Like anyone else, their moral and legal philosophies might make them lean one way or another politically, not the other way around. Even for the most extremely political justices, to hear them expound on the legal principles of federalism or human rights is very fascinating. It's ea…

Liberal vs. conservative has always been the wrong take. The stronger dividing line is textualism vs pragmatism. In fact Scalia famously said this coming from a textualist perspective which I think most people can agree with even if they hate him: “ If you’re going to be a good and faithful judge, you have to resign yourself to the fact that you’re not always going to like the conclusions you reach.” This seems absol…

> The stronger dividing line is textualism vs pragmatism.

Except when it came to "textualism vs pragmatism", I've seen that the "textualist" judges have, in many cases, no problem being "pragmatists" when it suits their desired outcome on an issue.

For example, when Scalia dissented in some famous gay rights cases (I'm thinking of Lawrence v Texas specifically) his basic disgust at the thought of same sex relations was laid bare. Ironically, in Lawrence v Texas his dissent was basically correct - striking down laws against sodomy was a step towards gay marriage - but the gist of his argument was that gay marriage was such a god awful, horrible, unthinkable thing that any decision that allowed it must be prima facie wrong. He was basically warning "This decision will force us to allow gay marriage" as if, instead of that being a good thing, it was akin to allowing the apocalypse.

Scalia also authored the 5-4 decision in District of Columbia v. Heller, a major second amendment case that held, for the first time, that individuals had a private right to own guns (not just "a well-regulated militia"). Read up on that case, as tons of "conservative" judicial scholars argued that it was "pulled from thin air" just as much as Roe v Wade was. From the Wikipedia page:

> Richard Posner, judge for the United States Court of Appeals for the Seventh Circuit, compares Heller to Roe v. Wade, stating that it created a federal constitutional right that did not previously exist, and he asserts that the originalist method – to which Justice Antonin Scalia claimed to adhere – would have yielded the opposite result of the majority opinion.

>> The text of the amendment, whether viewed alone or in light of the concerns that actuated its adoption, creates no right to the private possession of guns for hunting or other sport, or for the defense of person or property. It is doubtful that the amendment could even be thought to require that members of state militias be allowed to keep weapons in their homes, since that would reduce the militias' effectiveness. Suppose part of a state's militia was engaged in combat and needed additional weaponry. Would the militia's commander have to collect the weapons from the homes of militiamen who had not been mobilized, as opposed to obtaining them from a storage facility? Since the purpose of the Second Amendment, judging from its language and background, was to assure the effectiveness of state militias, an interpretation that undermined their effectiveness by preventing states from making efficient arrangements for the storage and distribution of military weapons would not make sense.

Re: Supreme Court blocks controversial Purdue Pharma opioid settlement

#459
post #419
post #389

Earlier quoted context omitted.

Yes of course there are realistic ways to prescribe opioids routine and safely. Purdue did not invent opioids, what they did is patent a particularly strong formulation, and then work to undermine the cultural taboo in medicine around their use. That last thing was their crime. There isn't, at this time, any other way to treat serious pain (in all cases). Opioid prescriptions will continue to be an unfortunately nece…

> Opioids can't be banned until we can replace them with something equally generally effective. Opioids should not be banned Opioid addiction (I have seen a lot of it, not had it) is a social problem and is best managed with, opioids The problems stem from putting unreasonable obstacles between adicts amd their appropriate treatment. Practical legal and financial obstacles, sadistic legal obstacles, and bizarre moral…

> Opioid addiction (I have seen a lot of it, not had it) is a social problem and is best managed with, opioids

I don't entirely disagree with you, but I have also seen enough people stop, who probably wouldn't have if that were the typical treatment, to be pretty cautious about that. There are a number of promising addiction treatments in the wings at the moment, in particular Ozempic and the general GLP-1 agonist class.

Transitional opioids like Buprenorphine are fine as a detox strategy, and maybe even fine for the medium term, but committing to them for life I think is a mistake (in most cases).

> The problems stem from putting unreasonable obstacles between adicts amd their appropriate treatment. Practical legal and financial obstacles, sadistic legal obstacles, and bizarre moral obstacles

There is a lot of truth to this. It is, in fact, what I used to say when I used them. And it is and remains true. It is also true that prolonged opioid use is mostly physiologically harmless (overdoses notwithstanding). However, there are psychological elements that come with long term use that these measures do not capture, and are not fully internalized by the transaction costs (or literal costs) associated with obtaining them.

> Nineteenth century society managed it with laudinum

Ask China why they fought that opium war, and how they feel about such things lately. They are still mad about it.

> The Sacklers are, were, parasites profiting from that social malaise and bad things will finally happen to them. But the cause of the malaise is our irrational attitude to drugs

Agree on the Sacklers although personally I'd place more blame on the McKinsey consultants that wrote the original deck that proposed the strategy. I don't know how much the Sackler individuals personally made these decisions, but those people certainly did.

Re: irrational attitudes to drugs, I agree, but the situation is substantially more nuanced than it might superficially appear. Laudanum did used to be over the counter, as did cocaine among other things. However, these things were not criminalized for no reason - heroin wasn't criminalized in the 60s/70s anti-hippie craze, or for racist reasons in the 1930s (like marijuana).

Heroin was first criminalized for over the counter sale in 1910 - 15 years after Bayer first marketed it. Easily the fastest criminalization of a novel pharmaceutical compound in the history of the world. This is not an accident or a product of some temporary social hysteria. And unfortunately, it was also not criminalized because all of its harms were due to its being illegal.

If criminality were the problem we would expect things to get better, not worse, with the introduction of fentanyl which is far cheaper and more readily available. I could be misreading the data, but that does not seem to be working out.

Re: Supreme Court blocks controversial Purdue Pharma opioid settlement

#460

Earlier quoted context omitted.

> That last thing was their crime Taboos are bullshit. Either something is a clearly articulated, written, rule with an enforcement mechanism, or it's fair game. Prescribing doctors are responsible for the opioid epidemic. Doctors failed in their duty of care to patients. Doctors massively overprescribed, failed to track their patient's medication usage, and failed to spot addictive behaviour. Why aren't we holding t…

Purdue aggressively marketed OxyContin as having a very small rate of addiction to doctors who weren't pain specialists and thus had little experience with controlled medications, while providing a dosing regime that was almost designed to cause addiction. (It's sole advantage was as a timed-release medication; if pain returned before time for the next dose, doctors were instructed (strongly) to raise the dosage rath…

> . (It's sole advantage was as a timed-release medication; if pain returned before time for the next dose, doctors were instructed (strongly) to raise the dosage rather than increase the number of doses per day.)

The same thing happens with ADHD medications, the timed release dosages are supposed to last 12+ hours, but in reality they vary from 8 to 16.

Thankfully most doctors will willingly prescribe a small after lunch short acting dose.

There is a large delta between the average response curve and an individual's response curve!

Post reply on HN