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Viagra improves brain blood flow and could help to prevent dementia

ox.ac.uk

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Re: Viagra improves brain blood flow and could help to prevent dementia

#281

Post by CydeWeys »

hombre_fatal wrote: post #203
CydeWeys wrote: post #129

Earlier quoted context omitted.

That's not a randomized controlled trial though. You might find a correlation, but you couldn't actually establish causation, or eliminate hidden variables.

We have to get over this false meme where people think RCTs prove causation and the rest prove correlation. An RCT doesn’t prove causation, it only might observe another correlation that contributes to our causal inferences based on the convergence of evidence. We don’t have RCTs for most things that you take for granted.

Well, an observational-only study proves even less.

Re: Viagra improves brain blood flow and could help to prevent dementia

#282

Post by talldatethrow »

exodust wrote: post #171
talldatethrow wrote: post #98

Earlier quoted context omitted.

Were you taking authentic or internet genetics from China/India? Ive gone through a decent amount of generics over the years, from several sources, and even though the label is the same, they almost all act differently on me. Some give me a flushed red face. Some cause a dull headache. Some don't cause anything negative thank God. They all work though. I think the Indian/Chinese ones are laced with garbage and what I…

The one time I used it over a few weeks was a generic brand. The on-label effect worked, but I had one disturbing side effect: terrible nightmares. Unscientific conclusion, but the nights I took it when with my new gf at the time, nightmares followed. Binned the remaining pills, nightmares vanished. Possibly the generic additives factor, or maybe the drug itself. Who knows, never tried it again after that.

From my experience taking it hundreds of times over 10+ years, from at least 10 different sources.. since almost every source had a distinctive side effect from the others, while entire packets of some sources had zero side effects for me... I'd blame the shady quality of the genetics more likely than the actual original drug.

I'm sure the real drug has some mild side effects too for some people, but the fact that I can distinctively tell the difference between sources makes me think a lot of other stuff is making it into the generics.

Re: Viagra improves brain blood flow and could help to prevent dementia

#283

Post by antonyt »

ezekiel68 wrote: post #87
Aurornis wrote: post #62

Earlier quoted context omitted.

That’s a standard dose. 3X per day is because it has a short half life. > Is anyone aware of research that shows positive benefits to health at recreational doses? Recreational doses? What does that mean? Excessive vasodilation isn’t going to be fun. You actually need some vasoconstriction to balance your blood pressure. Too much and you’re just going to get headaches and lightheaded. Excessive vasodilation would be…

> Recreational doses? What does that mean? I mean, we don't need to act obtuse here in the name of pedantry. Commenter was clearly referring to occasional use for on-label indication.

Giving the parent the benefit of the doubt, they probably were confused by the idea of people taking these pills to get high. That's generally what is meant by the term "recreational use" when it comes to drugs.

Re: Viagra improves brain blood flow and could help to prevent dementia

#284

Post by pcthrowaway »

Fire-Dragon-DoL wrote: post #267
idiotsecant wrote: post #140

Earlier quoted context omitted.

I'm pretty sure you don't just get random erections unless you're engaged in activity that you find sexually stimulating. ...so yes, probably.

Isn't random erections a requirement for healthy genitalia in males?

Not exactly 'random'. I mean, typically it would be during periods of relaxation and certain stages of sleep.

Adult males in their 30s or older very rarely just get a random erection with no physical or mental stimulation while going about their business.

Re: Viagra improves brain blood flow and could help to prevent dementia

#285

Post by Aerbil313 »

xgkickt wrote: post #41

I’d like to see how this effect from Sildenafil compares to increased NO levels from eating beets.

IIRC the benefit of viagra comes from increased NO in blood. You naturally get no when you breathe from your nose. I'd like to see a research on viagra use and mouthbreathing relation.

Re: Viagra improves brain blood flow and could help to prevent dementia

#286

Post by alfiedotwtf »

hooverd wrote: post #250
alfiedotwtf wrote: post #234

Earlier quoted context omitted.

Off-topic but related… I started Vyvanse about 3 months ago and the only negative side effect so far is tinnitus. It’s bloody loud :(

It can also be caused by SSRIs and NDRIs and benzos! Great side effect if you're already feeling depressed. Although benzos can also help, depending. I think 80% of cases are a brain thing and not an ear thing, but because ENTs and audiologists have exactly one hammer (hearing aids), we get fuck all for research.

Yeah, definitely a brain thing. Once it wears off, no more tinnitus :)

But I’d rather tinnitus and focus, than silence but scattered!

Re: Viagra improves brain blood flow and could help to prevent dementia

#287

Post by cactusplant7374 »

salad-tycoon wrote: post #280
cactusplant7374 wrote: post #13

Earlier quoted context omitted.

It's possible to order it from Indian pharmacies or one can pick it up while on vacation in the third world.

Yes, but how do you know what it really is? Plenty of legit generics have been found to be complete bunk,(1) let alone gray market ED drugs. Other generics have high levels of cancer causing contaminates. Eg TMAO in metformin, chantix, ranitidine, and more. 2 You can also buy these things as research chemical but same question as above. Always remember, made in USA is likely a misdirection. You buy this stuff in bulk…

All of the big drug companies have factories in India. Buying powder on Alibaba will be a much different experience.

Re: Viagra improves brain blood flow and could help to prevent dementia

#288

Post by ekianjo »

alexey-salmin wrote: post #225
ekianjo wrote: post #155

Earlier quoted context omitted.

you dont get antibodies against viruses just by thinking you have them.

And yet such thinking can in some cases increase your chances of surviving the viral infection. That's the placebo effect.

where did you see something like that?

Re: Viagra improves brain blood flow and could help to prevent dementia

#289

Post by ekianjo »

tux3 wrote: post #172
ekianjo wrote: post #155

Earlier quoted context omitted.

you dont get antibodies against viruses just by thinking you have them.

Even if this is obviously true, that does nothing to support the original statement. That's a whole different claim that you had to fall back to. Which is a motte-and-bailey type of argument.

if the placebo effect only works for a minority of ailments then its probably something else like you know, regression to the mean
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