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Viagra improves brain blood flow and could help to prevent dementia

ox.ac.uk

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Re: Viagra improves brain blood flow and could help to prevent dementia

#81

Post by ezekiel68 »

WalterBright wrote: post #58

First NIH said it does: https://www.nih.gov/news-events/nih-research-matters/viagra-... Then it doesn't: https://www.nih.gov/news-events/news-releases/nih-dream-stud... Then it does: https://www.ox.ac.uk/news/2024-06-07-sildenafil-viagra-impro... Who knows what to believe.

> Who knows what to believe.

This may be a sincere statement, but I'm not sure it's a helpful one. What data do we have? A 2:1 advantage in published studies that it does help. Since there is no such thing in science as absolute proof of anything, these are pretty good odds. Certainly more work will be done in the future to try to replicate the results and figure out the one negative outcome. But until then, we cannot say that the evidence is in any way "equal" on both sides.

Re: Viagra improves brain blood flow and could help to prevent dementia

#82

Post by Scoundreller »

elzbardico wrote: post #73

Well. too sad I can't take it. It gives me terrible heartburn (an acute stomach pain, not a heart related condition) that only partially responds to anti-acids such as Alka Seltzer. Also, extremelly stuffy nose, to the point where basically I need to breath by the mouth. And the red eyes, eyes as red as if had just smoke the biggest and strongest joint ever. Yes, I tried to use it recreationally a few times. It is no…

Sildenafil is fairly short acting, so that’s probably the reason for 3x/day (but a better choice if you don’t need a whole day of effects because of its side effects like sinus congestion).

Tadalafil (Cialis) would probably be a better choice, and is used at daily (but reduced) dosing for prostrate issues.

Re: Viagra improves brain blood flow and could help to prevent dementia

#83

Post by CydeWeys »

pcloadletter_ wrote: post #79
WalterBright wrote: post #58

First NIH said it does: https://www.nih.gov/news-events/nih-research-matters/viagra-... Then it doesn't: https://www.nih.gov/news-events/news-releases/nih-dream-stud... Then it does: https://www.ox.ac.uk/news/2024-06-07-sildenafil-viagra-impro... Who knows what to believe.

Maybe these studies are particularly hard

They certainly are hard, because dementia is something that develops over years if not decades. Anytime it takes that long to do a single iteration of your experiment, it's hard!

Re: Viagra improves brain blood flow and could help to prevent dementia

#84

Post by beachy »

justinc8687 wrote: post #78
beachy wrote: post #53

Earlier quoted context omitted.

Just hijacking to add a public health warning about BPH. Like many men as they get older, I was getting up several times a night to pee. Thought I would just put up with it until it got worse. I went on a yacht for the weekend, drank quite a few beers and crashed to sleep. I awoke to find out I couldn't pee at all. I can't describe how painful things were by the time I staggered into the emergency department that eve…

Is there some correlation to boats or just happenstance?

Just coincidence, situations where one might drink too much and be isolated from medical care.

Re: Viagra improves brain blood flow and could help to prevent dementia

#86

Post by wumbo »

saulpw wrote: post #33
sva_ wrote: post #26

> The OxHARP trial was a meticulously designed double-blind, placebo-controlled study involving 75 participants who had experienced a minor stroke and showed signs of mild to moderate small vessel disease. Each participant received sildenafil, a placebo, and cilostazol (a similar drug) over three-week periods in a randomised order. I feel like dudes will know if they got Viagra or not? It doesn't seem like cilostazol…

Viagra doesn't "make" you hard, you still need sexual stimulus. I've taken it and then the sexual opportunity fell through, so I went back to coding or whatever, and I didn't notice anything different.

Severe warning. I have no sexual problems and took a viagra once.

It definitely was automatic and persistent.

It was terrible. It wouldn’t even go away when I was done with it.

Re: Viagra improves brain blood flow and could help to prevent dementia

#87

Post by ezekiel68 »

Aurornis wrote: post #62
Arthanos wrote: post #42

50mg 3x a day, according to the study: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.124.32432... Seems high to me, but I've never taken the drug. I assume most people take it just a few times a week for it's intended use? Is anyone aware of research that shows positive benefits to health at recreational doses?

That’s a standard dose. 3X per day is because it has a short half life. > Is anyone aware of research that shows positive benefits to health at recreational doses? Recreational doses? What does that mean? Excessive vasodilation isn’t going to be fun. You actually need some vasoconstriction to balance your blood pressure. Too much and you’re just going to get headaches and lightheaded. Excessive vasodilation would be…

> Recreational doses? What does that mean?

I mean, we don't need to act obtuse here in the name of pedantry. Commenter was clearly referring to occasional use for on-label indication.

Re: Viagra improves brain blood flow and could help to prevent dementia

#88

Post by ezekiel68 »

doubloon wrote: post #61

you know what else would? walkable cities more time off from work more third spaces less air pollution less inequality of course none of that "increases productivity or GDP" so the ruling class won't consider it. of course when they start dying like Japan with low birth rates, their 'solution' is to have a government funded dating app instead of doing the obvious.

Nah, man.

I'll take the Capitalism and the pills.

Re: Viagra improves brain blood flow and could help to prevent dementia

#89

Post by Dylan16807 »

demondemidi wrote: post #46
mpenick wrote: post #32

Saunas, hot baths, and excercise improve blood flow.

This is America: we demand a low-effort, overpriced solution, preferably in pill form.

Saunas and hot baths are low-effort too, but they get pretty expensive time-wise.

And these pills are pretty cheap.

Re: Viagra improves brain blood flow and could help to prevent dementia

#90

Post by demondemidi »

senordevnyc wrote: post #67
demondemidi wrote: post #46

Earlier quoted context omitted.

This is America: we demand a low-effort, overpriced solution, preferably in pill form.

Not everyone on HN is from the US, and the study in question is from the UK...

Do you have jokes where you live?
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