Wasn't this class of medication originally for cardiovascular issues, and the whole ED mitigation was a happy marketable accident?
many drugs are found by accident
Viagra improves brain blood flow and could help to prevent dementia
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Re: Viagra improves brain blood flow and could help to prevent dementia
#72It needs prescription, correct?
In the US, it does but the bar is laughably low. For example, you can get a prescription on blewchew.com which gets "reviewed" by their "consulting physicians" and have it in hand in a day or two.
Re: Viagra improves brain blood flow and could help to prevent dementia
#73Well. too sad I can't take it. It gives me terrible heartburn (an acute stomach pain, not a heart related condition) that only partially responds to anti-acids such as Alka Seltzer.
Also, extremelly stuffy nose, to the point where basically I need to breath by the mouth. And the red eyes, eyes as red as if had just smoke the biggest and strongest joint ever.
Yes, I tried to use it recreationally a few times. It is not worth the pain for me.
And then the dosage in the study: 50mg 3X times a day? I am not sure I could even survive the first day.
Did I mention the headaches too?
EDIT: Before someone asks... At least the on-label effect works really well in a recreational setting for me. But it is kind of funny to have persistent carbon-steel erections when you're feeling miserable with stomach pain and can't breath well. Doing oral sex with a stuffy nose is... interesting.
Re: Viagra improves brain blood flow and could help to prevent dementia
#74> The OxHARP trial was a meticulously designed double-blind, placebo-controlled study involving 75 participants who had experienced a minor stroke and showed signs of mild to moderate small vessel disease. Each participant received sildenafil, a placebo, and cilostazol (a similar drug) over three-week periods in a randomised order. I feel like dudes will know if they got Viagra or not? It doesn't seem like cilostazol…
Maybe, but maybe not. If I told you I'm either giving you actual viagra or a placebo, you might get more aroused even if given placebo. Because psychologically you'll be thinking "There's at least a chance I took viagra right now"
the placebo effect does not work like that. You dont get physiological benefits just by thinking you have them.
Re: Viagra improves brain blood flow and could help to prevent dementia
#75I’d like to see how this effect from Sildenafil compares to increased NO levels from eating beets.
If nothing else, you're making me imagine some new scenes involving Dwight Schrute :)
Re: Viagra improves brain blood flow and could help to prevent dementia
#76First NIH said it does: https://www.nih.gov/news-events/nih-research-matters/viagra-... Then it doesn't: https://www.nih.gov/news-events/news-releases/nih-dream-stud... Then it does: https://www.ox.ac.uk/news/2024-06-07-sildenafil-viagra-impro... Who knows what to believe.
I’ve always been taught that “a wank a day keeps the doctor away” so I believe it.
Re: Viagra improves brain blood flow and could help to prevent dementia
#77you know what else would? walkable cities more time off from work more third spaces less air pollution less inequality of course none of that "increases productivity or GDP" so the ruling class won't consider it. of course when they start dying like Japan with low birth rates, their 'solution' is to have a government funded dating app instead of doing the obvious.
Less air pollution does increase productivity (air pollution is actually really bad for your mental performance, it's a surprisingly strong effect) and it seems to me "the ruling class" does consider it seeing as the Clean Air Act exists. Btw, Japan has walkable cities of course but also has low inequality (but not so high wealth). Approximately nothing is known to increase birth rates except for being highly religio…
"Japan doesn't have walkable cities" is not a logical conclusion one can draw from the grandparent.
Re: Viagra improves brain blood flow and could help to prevent dementia
#78Earlier quoted context omitted.
It is prescribed for benign prostatic hyperplasia (BPH; an enlarged prostate) which include difficulty urinating—not just for ED
Just hijacking to add a public health warning about BPH. Like many men as they get older, I was getting up several times a night to pee. Thought I would just put up with it until it got worse. I went on a yacht for the weekend, drank quite a few beers and crashed to sleep. I awoke to find out I couldn't pee at all. I can't describe how painful things were by the time I staggered into the emergency department that eve…
Is there some correlation to boats or just happenstance?
Re: Viagra improves brain blood flow and could help to prevent dementia
#79First NIH said it does: https://www.nih.gov/news-events/nih-research-matters/viagra-... Then it doesn't: https://www.nih.gov/news-events/news-releases/nih-dream-stud... Then it does: https://www.ox.ac.uk/news/2024-06-07-sildenafil-viagra-impro... Who knows what to believe.
Maybe these studies are particularly hard
Re: Viagra improves brain blood flow and could help to prevent dementia
#80Earlier quoted context omitted.
Maybe, but maybe not. If I told you I'm either giving you actual viagra or a placebo, you might get more aroused even if given placebo. Because psychologically you'll be thinking "There's at least a chance I took viagra right now"
the placebo effect does not work like that. You dont get physiological benefits just by thinking you have them.
Being more aroused is not a physiological benefit.
To have no placebo effect, the random patients in the brain blood flow trial would need to all be unable to get erections, or something.