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Viagra improves brain blood flow and could help to prevent dementia

ox.ac.uk

31–40 of 289 posts

Re: Viagra improves brain blood flow and could help to prevent dementia

#33
post #26

> The OxHARP trial was a meticulously designed double-blind, placebo-controlled study involving 75 participants who had experienced a minor stroke and showed signs of mild to moderate small vessel disease. Each participant received sildenafil, a placebo, and cilostazol (a similar drug) over three-week periods in a randomised order. I feel like dudes will know if they got Viagra or not? It doesn't seem like cilostazol…

Viagra doesn't "make" you hard, you still need sexual stimulus. I've taken it and then the sexual opportunity fell through, so I went back to coding or whatever, and I didn't notice anything different.

Re: Viagra improves brain blood flow and could help to prevent dementia

#34

Viagra increases the effect of nitric oxide, which is bad stuff when it gets into cytochrome complex iv in the mitochondria (IIRC). I would personally suspect based on that, that its effects on brain health would be negative in spite of blood flow.

Nitric oxide bad for you? Pretty sure it is good for you ,otherwise super foods like beets and leafy greens would be bad for you.

Re: Viagra improves brain blood flow and could help to prevent dementia

#35

Wasn't this class of medication originally for cardiovascular issues, and the whole ED mitigation was a happy marketable accident?

I vaguely recall an anecdote about athletes using it for performance improvement, and getting a slightly different stat buff

It's commonly used in bodybuilding competitions.

Re: Viagra improves brain blood flow and could help to prevent dementia

#38
post #26

> The OxHARP trial was a meticulously designed double-blind, placebo-controlled study involving 75 participants who had experienced a minor stroke and showed signs of mild to moderate small vessel disease. Each participant received sildenafil, a placebo, and cilostazol (a similar drug) over three-week periods in a randomised order. I feel like dudes will know if they got Viagra or not? It doesn't seem like cilostazol…

Maybe, but maybe not. If I told you I'm either giving you actual viagra or a placebo, you might get more aroused even if given placebo. Because psychologically you'll be thinking "There's at least a chance I took viagra right now"

Re: Viagra improves brain blood flow and could help to prevent dementia

#40

Wasn't this class of medication originally for cardiovascular issues, and the whole ED mitigation was a happy marketable accident?

That is true that it was originally for cardiovascular issues.

However, it seems that there was at least theoretical consideration that it could be used to treat ED

A nice overview is here:

https://www.nature.com/articles/nrd2030

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