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World-first tooth-regrowing drug will be given to humans in September

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Re: World-first tooth-regrowing drug will be given to humans in September

#13

A friend I know hopes this can be available to everyone soon. He's suffered from cavities for most of his life, and its shocking he hasn't had to have a tooth pulled. While he isn't the best on dental hygiene I know he tries....but his medication and genetics kinda skew any efforts he makes. He jokes that he'd be lucky to have teeth by 50 still left, and in his case I feel bad for him because he does all he really ca…

There are better toothpastes out there that use more than fluoride. Sensodyne with Novamin is one (but you need to import it), along with many that have hydroxyapatite. The latter often don’t have fluoride but there are some with both.

Re: World-first tooth-regrowing drug will be given to humans in September

#15

I wonder if this or something like it could be used for osteoperosis and/or other aging related bone density issues.

With the right really difficult to get right knowledge and intervention vectors, biological organisms can be hacked all you want. To me, it’s not a question of “if” but of “how expensive”, “when” and “maybe making a silicon-based sucesor species to Homo Sapiens is the madness we settle for.”

Re: World-first tooth-regrowing drug will be given to humans in September

#16
If it can boost density in existing teeth, even that's a big deal. Probably more valuable than regrowing.

I am a 49-year-old and (apart from the four teeth removed in my teens so that orthodontics could straighten and resolve overcrowding) at the moment I have all my teeth, wisdom teeth included.

(It looks like one wisdom tooth might not be long for this mouth, but I digress)

But once you get to this age, the density of your teeth begins to matter.

What would be really great is a treatment that would regrow gums in a meaningful, controlled way that supported reattachment; some of my gums are receding for reasons that are developmental, and some is less than ideal self-care, but much of it is just plain being a man over 40.

There are some medications that cause gum overgrowth as a side effect, but not usefully.

Re: World-first tooth-regrowing drug will be given to humans in September

#17

I wonder if this or something like it could be used for osteoperosis and/or other aging related bone density issues.

The article suggests it does boost bone density in existing teeth so I think the question I'd want to see answered is why doesn't it have an effect on osteoporotic bone?

Re: World-first tooth-regrowing drug will be given to humans in September

#18
post #10
post #9

The USAG-1 protein has a high amino acid homology of 97% between different animal species, including humans, mice, and beagles. I have 0 knowledge in this area, just curious, but are beagles specifically close to human physiology for the purposes of testing this treatment? I would’ve thought any dog breed is going to be like any other dog breed.

They had to find a breed that is, on average, as intelligent as an average human. Animal model optimality, and all that. Border collies were too smart so they had to use beagles.

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Re: World-first tooth-regrowing drug will be given to humans in September

#19
post #10
post #9

The USAG-1 protein has a high amino acid homology of 97% between different animal species, including humans, mice, and beagles. I have 0 knowledge in this area, just curious, but are beagles specifically close to human physiology for the purposes of testing this treatment? I would’ve thought any dog breed is going to be like any other dog breed.

They had to find a breed that is, on average, as intelligent as an average human. Animal model optimality, and all that. Border collies were too smart so they had to use beagles.

[deleted]
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