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World-first tooth-regrowing drug will be given to humans in September

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Re: World-first tooth-regrowing drug will be given to humans in September

#3
A friend I know hopes this can be available to everyone soon. He's suffered from cavities for most of his life, and its shocking he hasn't had to have a tooth pulled.

While he isn't the best on dental hygiene I know he tries....but his medication and genetics kinda skew any efforts he makes. He jokes that he'd be lucky to have teeth by 50 still left, and in his case I feel bad for him because he does all he really can yet still has cavities and needs fillings regularly.

Re: World-first tooth-regrowing drug will be given to humans in September

#4
This would be amazing. I've got one tooth missing and the prospect that maybe in a decade or so I could grow it back? Wow.

Really hope this trial works out. Of all the things I thought we'd be trialling regrowth of first, I would never have guessed teeth. But actually I never thought anything like this would happen in my lifetime.

Re: World-first tooth-regrowing drug will be given to humans in September

#5

A friend I know hopes this can be available to everyone soon. He's suffered from cavities for most of his life, and its shocking he hasn't had to have a tooth pulled. While he isn't the best on dental hygiene I know he tries....but his medication and genetics kinda skew any efforts he makes. He jokes that he'd be lucky to have teeth by 50 still left, and in his case I feel bad for him because he does all he really ca…

I am in my mid 30s now and unfortunately due to genetics on my mother's side (diabetes and high blood pressure) and with tartar/plaque buildup accelerated the process and now I have periodontitis where the bone the teeth is lost (the left upper side from the 3rd molar to the 2nd bicuspid).

I still have my teeth, but not for long (probably not to even my 40s). While teeth cleaning and tartar removal every few weeks helps slowing this process, its not going to stop it.

I pray that this breakthrough happens (even though it will probably take 5 to 10 years until we have something viable that we can pay for).

Re: World-first tooth-regrowing drug will be given to humans in September

#6
That would be a massive quality of life improvement for me. I've had a lot of issues with my teeth and while being in my thirties I currently need at least 4 implants to get close to a properly functioning dentition. And that still leaves a lot of empty space in the back that makes my speech inherently more slurred.

Re: World-first tooth-regrowing drug will be given to humans in September

#7

A friend I know hopes this can be available to everyone soon. He's suffered from cavities for most of his life, and its shocking he hasn't had to have a tooth pulled. While he isn't the best on dental hygiene I know he tries....but his medication and genetics kinda skew any efforts he makes. He jokes that he'd be lucky to have teeth by 50 still left, and in his case I feel bad for him because he does all he really ca…

Your friend should take a look at Lumina. It's a treatment to inoculate yourself with a strain of s.mutans that does not produce lactic acid and will remain dominant against other strains. Depending on the root cause of his cavities, it is possible that it would completely eliminate them.

The mutation occurs naturally; if you have heard of entire families who do not get cavities or children 'growing out' of getting cavities, my understanding is that it is usually correlated with the natural spread of this variant of s.mutans.

Re: World-first tooth-regrowing drug will be given to humans in September

#9

  The USAG-1 protein has a high amino acid homology of 97% between different animal species, including humans, mice, and beagles.
I have 0 knowledge in this area, just curious, but are beagles specifically close to human physiology for the purposes of testing this treatment? I would’ve thought any dog breed is going to be like any other dog breed.

Re: World-first tooth-regrowing drug will be given to humans in September

#10
post #9

The USAG-1 protein has a high amino acid homology of 97% between different animal species, including humans, mice, and beagles. I have 0 knowledge in this area, just curious, but are beagles specifically close to human physiology for the purposes of testing this treatment? I would’ve thought any dog breed is going to be like any other dog breed.

They had to find a breed that is, on average, as intelligent as an average human. Animal model optimality, and all that. Border collies were too smart so they had to use beagles.
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