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Metabolism of autism reveals developmental origins

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Re: Metabolism of autism reveals developmental origins

#241

Post by euglenoid »

ModernMech wrote: post #183
MajimasEyepatch wrote: post #144

Earlier quoted context omitted.

> My ability to type this message and read is not a constant. There are times when I am non verbal. There are times when I cannot read because the letters are all jumbled in my head. When I'm able to read and write and speak, society values me. When I'm not, society devalues me. You want to take autism out of the equation so that I can be valuable to society. > What I'm saying is that society needs to be reoriented s…

> If someone can’t communicate, how exactly are they supposed to participate fully in society? It's not that autistic people cannot communicate, it's that we communicate differently. For example, I cannot talk on the phone. I just can't. I could explain all the reasons why, but I feel very dismissed here so I'm not going to be vulnerable anymore, but suffice it to say it's something I cannot do, and a lot of autistic…

[dead]

Re: Metabolism of autism reveals developmental origins

#242

Post by Animats »

ta988 wrote: post #222
Animats wrote: post #220

Earlier quoted context omitted.

"Of 50 biochemical pathways and 450 polar and lipid metabolites examined, the developmental regulation of the purine network was most changed. Purine network hub analysis revealed a 17-fold reversal in typically developing children. This purine network reversal did not occur in ASD." That's a strong statement, and one which can be checked by others. Anyone trying to replicate this yet?

The article was published today, and study like that take months to do and then months again to be published especially in this kind of journals (thankfully they don't accept replications most of the time so it can get published by more reasonable venues).

Right. This is a result which indicates a research direction worth pursuing. That's about it for now.

Re: Metabolism of autism reveals developmental origins

#243

Post by lynguist »

discretion22 wrote: post #102
Waterluvian wrote: post #75

Earlier quoted context omitted.

When “comorbidity” is used in this context, are we actually referring to people dying because of it? Or does it just mean “are found together when discussing this disease?”

The Latin morbus is disease and mortis is [of] death but my experience - and perhaps yours too - is that when discussions of morbidity (i.e. using the word morbid/morbidity) arise, they are often in the context where someone is near death or has died so it is a natural linguistic connection to make. Remarkably often I find my partner has a different understanding of English words from me - she was schooled in French…

What are some of your word examples?

I recently learned that we use triumph to mean victory, but triumph was originally the ceremonial parade after a military victory.

Re: Metabolism of autism reveals developmental origins

#245

Post by yareal »

Der_Einzige wrote: post #11

I know of at least one book written by and for autistic people who advocates for a gluten free diet. They claim in the book that this significantly reduces their symptoms. I don’t know if I believe it or not, but the notion of gut-brain axis seems to imply that a good diet should help a bit, right?

As an autistic person, professionally diagnosed, this sounds like nonsense woo. Yes, gut bio can influence moods and managing your health can improve symptoms from autism (e.g. meditation might help manage anxiety).

But no amount of "don't eat bread" is going to help me understand faces or social cues. A good diet might help with self esteem, overall energy levels, and resilience to my symptoms (if I'm healthier, I shut down less). But that's it, it's not going to change the way I experience the world, just stretch my tolerance for it.

Re: Metabolism of autism reveals developmental origins

#246

Post by asdfman123 »

grumpy-de-sre wrote: post #55

On the topic of metabolic disturbances in Autism, huge fan of the work Dr. Randy Blakely is doing on the links between Serotonin metabolism and Autism. One of the most surprising, and strongest (25-30% of patients), biomarkers for Autism is actually Platelet Hyperserotonemia (high levels of bound Serotonin in the blood). For decades it's been without explanation but recently Dr Blakely has described a bunch of cases…

Genuine question: how do we know that's not just a side effect instead of a driver?

Re: Metabolism of autism reveals developmental origins

#247

Post by yareal »

r3trohack3r wrote: post #168
squigz wrote: post #159

Earlier quoted context omitted.

> And that many common chronic disorders/illnesses (including ADHD, Autism, weight gain, etc) in our generation are actually attributable to a disfunctioning microbiome All of those things have existed for ... ever

They have. But I do not believe they were as common prior to the 1960s as they are in the 2020s.

In the 1960s you had to learn to mask your differences or you would suffer violence directed at you. We used to beat kids for not behaving in the ways we expect.

Get enough beatings, you learn to hide the thing that gets you beat.

I'm not at all convinced it was less common back then, just more hidden.

Re: Metabolism of autism reveals developmental origins

#249

Post by asdfman123 »

squigz wrote: post #159
r3trohack3r wrote: post #81

Earlier quoted context omitted.

Anecdotal, but we grow a heritage strain of wheat here in PHX (Sonoran White). Its appearance gives me pause. Common commercial wheat is very short in comparison. I have a friend who can’t eat “common” wheat products from the grocery store, having been diagnosed with severe gluten intolerance, but can eat Sonoran White without symptoms. You can follow the same exact recipe but substitute Sonoran White flour for stand…

> And that many common chronic disorders/illnesses (including ADHD, Autism, weight gain, etc) in our generation are actually attributable to a disfunctioning microbiome All of those things have existed for ... ever

That's absolutely not true. Diabetes for instance used to be extremely rare and limited to the elites.

And, for instance, ADHD probably isn't a disorder if you live a very simple life and do manual labor all day. No hyperactivity, no DMV appointments, and your life is decided for you. Remember, all the lines are drawn arbitrarily and something is labeled a disorder when it doesn't work with our (very strange) modern world.

Can't comment on autism though, and this is not directly about micro biome obviously.

Re: Metabolism of autism reveals developmental origins

#250

Post by asdfman123 »

Der_Einzige wrote: post #11

I know of at least one book written by and for autistic people who advocates for a gluten free diet. They claim in the book that this significantly reduces their symptoms. I don’t know if I believe it or not, but the notion of gut-brain axis seems to imply that a good diet should help a bit, right?

I'm hardly an expert on autism but I've fought ADHD for years, and good diet/lifestyle is essential.

Not sure how certain you are of your autism diagnosis, and I'm still not even sure where the line of demarcation is, but it may actually be ADHD. Worth considering.

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