Hard disagree on this.
I strongly believe that there is a TON of potential for synthetic biology-- but not in computation.
People just forget how superior current silicon is for running algorithms; if you consider e.g. a 17 by 17 digit multiplication (double precision), then a current CPU can do that in the time it takes for light to reach your eye from the screen in front of you (!!!). During all the completely unavoidable latency (the time any visual stimulus takes to propagate and reach your consciousness), the CPU does millions more of those operations.
Any biocomputer would be limited to low-bandwidth, ultra high latency operations purely by design.
If you solely consider AGI as application, where abysmal latency and low input bandwidth might be acceptable, then it still appears to be extremely unlikely that we are going to reach that goal via synthetic biology; our current capabilities are just disappointing and not looking like they are gonna improve quickly.
Building artificial neural networks on silicon, on the other hand, capitalises on the almost exponential gains we made during the last decades, and already produces results that compare to say, a schoolchild, quite favorably; I'd argue that current LLM based approaches already eclipse the intellectual capabilities of ANY animal, for example. Artificial bio brains, on the other hand, are basically competing with worms right now...
Also consider that even though our brains might look daunting from a pure "upper bound on required complexity/number of connections" point of view, these limits are very unlikely to be applicable, because they confound implementation details, redundancy and irrelevant details. And we have precise bound on other parameters, that our technology already matches easily:
1) Artificial intelligence architecture can be bootstrapped from a CD-ROM worth of data (~700MiB for the whole human genome-- even that is mostly redundant)
2) Bandwidth for training is quite low, even when compressing the ~20year training time for an actual human into a more manageable timeframe
3) Operating power does not require more than ~20W.
4) No understanding was necessary to create human intelligence-- its purely a result of an iterative process (evolution).
Also consider human flight as an analogy: we did not achieve that by copying beating wings, powered by dozens of muscle groups and complex control algorithms-- those are just implementation details of existing biological systems. All we needed was the wing-concept itself and a bunch of trial-and-error.