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Deaf girl is cured in world first gene therapy trial

independent.co.uk

171–180 of 351 posts

Re: Deaf girl is cured in world first gene therapy trial

#171

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It would be nice if people at these companies were rewarded the same way as food delivery app employees.

???? I would imagine the average surgeon is much happier with their compensation than the average DoorDasher. It's a reliable fixed-rate salary vs wondering if you'll get enough $3 tips to make rent this month.

Maybe gp was referring to the coders who work at said companies. I don't even think the individual dashers are employees.

Re: Deaf girl is cured in world first gene therapy trial

#172

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I don't agree with this point of view, but people with hearing shouldn't be so quick to dismiss it. Deaf people raise it every time medicine makes an advance in restoring hearing.

Oliver Sacks has written interesting things on this subject btw.

Re: Deaf girl is cured in world first gene therapy trial

#173

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Wow! There is a great gag in latest Star Trek where Spock reveals that Vulcans need to medically suppress their smell near humans because we just stink to their sensitive noses.

Here is another reference from Enterprise with T'pol: https://www.youtube.com/watch?v=tIYsVBaYNSU

It's a recurring thing in Enterprise, Archer's pet dog Porthos also bothers T'Pol at one point. I'm not sure but I think Enterprise was the one that introduced this aspect of Vulcans.

Re: Deaf girl is cured in world first gene therapy trial

#174

Every time I hear about a new medical discovery or treatment, I think "yeah right, maybe in 15 years". Well, here we finally are. Our ancestors, and I mean great-grandparents and grandparents, would call us gods.

I have profound hearing loss (sensorineural) in both ears, and I've been following gene therapy in all of its fits and starts for almost two decades. I was lucky enough to have _not horrible_ hearing at my youngest, and then lost it progressively up until I rely entirely on lip reading for conversation.

I was eligible for cochlear implants probably more than 15 years ago, but I was getting by, and I heard that getting implants would almost certainly preclude any future therapy like this. I'm ecstatic to finally hear an actual "it worked, in a human" outcome, and can't wait for something that works for my hearing to reach maturity.

Re: Deaf girl is cured in world first gene therapy trial

#175
post #97

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> I agree with that evaluation, but I also think mavericks should be allowed to try curing their own colorblindness (assuming they had informed consent and paid for the therapy themselves). I mean, what's stopping you? This guy cured his own lactose intolerance: https://www.youtube.com/watch?v=J3FcbFqSoQY But I'm guessing — in part because you say "paid for the therapy" — that you don't really mean "should be allowed…

FWIW, doctors usually specify brands over generics when it actually matters if you have the same supplier every time. Bioavailability of generics is +/- 20% compared to the original branded drug by law in the US. So if you have a legal, generic drug here, it might be a 120% one, and your next refill might be an 80% one - you just got a 1/3 reduction in dose without warning. And if you have seizures? That’s a bad thin…

True but it's not ±20%, it's "90% confidence interval of the mean is within +25%/-40%" which puts the dose much closer to 100% in practice.

https://www.pharmacytimes.com/view/debunking-a-common-pharma...

Still, these measured %ages should be much more explicit in the actual delivered drugs and in the range of values that are determined safe. There are plenty og drugs where double dose is fine and the therapeutic dose is "let's experiment on every patient evey day to see what works".

Re: Deaf girl is cured in world first gene therapy trial

#176
post #57

My Mom was born with less than half of her hearing in left ear and barely anything at all in right ear. She had surgery as an adult and it slightly improved, especially on the right side. Pretty sure this little girl and my Mom don't share the same disability at all but she saw these news today and texted me so excited because future kids won't have to endure the same. Brings tears to my eyes, I'm so grateful for mod…

It might be the condition I have, otosclerosis, where the bones of the middle ear fuse. The surgery, a stapedectomy, involves removing the bones and replacing them with a metallic prosthesis. Unfortunately, in my case, the calcification is also happening in my cochlea which means that at some indeterminate time in the future, I will end up losing all hearing. Not to mention that even with the prosthetic, my hearing i…

Did your sense of taste change after your surgery? My sister is considering a similar procedure and is concerned that everything could start tasting like hot garbage.

Re: Deaf girl is cured in world first gene therapy trial

#177
post #96
post #89

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The problem there isn't your receptors, which are UV sensitive. The problem is your lens, which filters it out. Remove the lens and you can see UV just fine. Until you get eyeball cancer, that is. UV is mutagenic. That's why you filter it out. People with cataracts get replacement lenses, and some exist that don't filter the UV. I think they're hard to get, what with the whole "eyeball cancer" thing. But if I get to…

Are you eyes more sensitive to UV than the rest of your body? I guess melanin absorbs UV in the skin, so this serves a similar purpose in the eye?

"Sensitivity to light" is the primary function of the eye.

Re: Deaf girl is cured in world first gene therapy trial

#178
post #132
post #66

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Colorblind person here. This debunking video is piling on more BS, like oh, colorblind people learned to be amazing at detecting slight color changes! No, we are not. We learned what names are attached to what color, but we see them differently, much poorer (save for blues). Enchroma apparently helps with separation, as parent comment suggests. That being said, the fake dramatic videos are definitely shameful scam, a…

What boggles my mind a bit is that true colorblindness glasses don't seem that difficult to me. Standard red-blue 3d glasses almost do it, it's just you need red-green differentiating glasses. I don't think this would Open the World of Color!, but it would with a bit of practice probably allow you to at least perceive a difference. But the glasses need to be visibly-differently (to a non-color-blind person) tinted. I…

RB 3GD glasses remove color to create a different image. I don't see how that would generalize to add color.

Re: Deaf girl is cured in world first gene therapy trial

#179

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I started smoking as a teenager and almost entirely lost my sense of smell. I later spent years working in cafes and bars and did a lot of food and beverage tastings where I used my limited sense of smell to the best of my ability and got pretty good at it . Eventually I met my favorite person, who didn't smoke, so I quit and over the course of the following weeks it felt like I was regaining my sense of smell with o…

Wow! There is a great gag in latest Star Trek where Spock reveals that Vulcans need to medically suppress their smell near humans because we just stink to their sensitive noses.

Babylon 5 had that with telepaths who sing songs to block out the noise of human thoughts.
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