Earlier quoted context omitted.
Yes. Take the age of the universe, multiple by the rate of expansion to get the total size of the universe, then multiple by the average density of galaxies in the observable universe. There are some further complications, but at the root it is basic algebra.
Replying to the other replies here - this regards the observable universe. Speed of light limits and all that. Of course we have no reason to believe the universe just stops at the point where we happen to lack the ability to observe.
The size and shape of the observable universe also changes. A moving observer, say someone doing 30% of lightspeed, will see further in one direction than another. Accelerate quickly enough and the "dark" side of your custom observable universe might catch up with you, causing all sorts of havoc.