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Psychiatric risks for worsened mental health after psychedelic use

journals.sagepub.com

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Re: Psychiatric risks for worsened mental health after psychedelic use

#2
> We find that 16% of the cohort falls into the “negative responder” subset.

“they should have known they had a family history of schizophrenia before using it!”

every dismissive psychedelic user that brags about increased empathy in the next breath

but in all seriousness, yes I would like to see more studies so we can at least have side effects printed on the side of the package, so the right people can take informed risks

Re: Psychiatric risks for worsened mental health after psychedelic use

#3
post #2

> We find that 16% of the cohort falls into the “negative responder” subset. “they should have known they had a family history of schizophrenia before using it!” every dismissive psychedelic user that brags about increased empathy in the next breath but in all seriousness, yes I would like to see more studies so we can at least have side effects printed on the side of the package, so the right people can take informe…

so 84% had a positive response?

Re: Psychiatric risks for worsened mental health after psychedelic use

#4
post #2

> We find that 16% of the cohort falls into the “negative responder” subset. “they should have known they had a family history of schizophrenia before using it!” every dismissive psychedelic user that brags about increased empathy in the next breath but in all seriousness, yes I would like to see more studies so we can at least have side effects printed on the side of the package, so the right people can take informe…

This makes sense because people that have used psychedelics sharing their positive experiences are the bad guys and people that have used psychedelics sharing their negative experiences are the good guys

Re: Psychiatric risks for worsened mental health after psychedelic use

#5
post #2

> We find that 16% of the cohort falls into the “negative responder” subset. “they should have known they had a family history of schizophrenia before using it!” every dismissive psychedelic user that brags about increased empathy in the next breath but in all seriousness, yes I would like to see more studies so we can at least have side effects printed on the side of the package, so the right people can take informe…

so 84% had a positive response?

84% positive and 16% worsened mental health is not the same thing as 84% and the rest neutral or mild side effects.

Re: Psychiatric risks for worsened mental health after psychedelic use

#6
post #2

> We find that 16% of the cohort falls into the “negative responder” subset. “they should have known they had a family history of schizophrenia before using it!” every dismissive psychedelic user that brags about increased empathy in the next breath but in all seriousness, yes I would like to see more studies so we can at least have side effects printed on the side of the package, so the right people can take informe…

so 84% had a positive response?

No.. 16% had a negative response, 28% had ~no response, and 55% had a positive response. I think people would be much more hesitant to try psychedelics for their mental issues if you told them it was a coin toss whether it would help or not -- and was an unlucky game of Russian Roulette from making their mental problems worse.

Re: Psychiatric risks for worsened mental health after psychedelic use

#7
I find the design and results somewhat underwhelming (weak significance in a N=800 sample with >50% dropout). The authors also mention that they lack power, but the only correct answer then is not to do the study, include more people, more data points, or reduce measurement variance.

That said, I think it's a refreshing perspective, and it seems like a good idea to look at effect heterogeneity in psychedelics use. Thinks like bayesian trees (BART) can help identify subgroups that react differently to stimuli along specific characteristics.

Re: Psychiatric risks for worsened mental health after psychedelic use

#8
Interesting that OCD is the winning disorder, with zero negative responders.

Recalling my mushroom days.... Okay, I think I get it. Psychedelic experience is, in part, about embracing the beautiful chaos of the universe. Surrendering to the charms of free-flowing wild information at scale so huge there's no chance of imposing your own orderly corrections - as you might in normal every day life via OCD. That's my armchair take anyway.

  Psychiatric history | Negative responders (%) | Non-responders (%) | Positive responders (%) 

  OCD | 0.0 | 25.0 | 75.0

Re: Psychiatric risks for worsened mental health after psychedelic use

#9
post #2

> We find that 16% of the cohort falls into the “negative responder” subset. “they should have known they had a family history of schizophrenia before using it!” every dismissive psychedelic user that brags about increased empathy in the next breath but in all seriousness, yes I would like to see more studies so we can at least have side effects printed on the side of the package, so the right people can take informe…

so 84% had a positive response?

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