Infant microbes and metabolites point to childhood neurodevelopmental disorders • Hacker News Board

Re: Infant microbes and metabolites point to childhood neurodevelopmental disorders

#81

Post by zoeysmithe » Mon, Apr 08, 2024, 4:33 PM UTC

empressplay wrote: post #31

calibas wrote: post #21

Remember the study that said autism and ADHD are linked to acetaminophen use during pregnancy? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385573/ Well it turns out that "Acetaminophen during bacterial colonization of the naïve gut is associated with lasting alterations in childhood microbiome composition": https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9367926/

...except that my mother never used Tylenol during her pregnancy with me and I'm absolutely ASD. I'm not saying these things don't have an influence on severity or presentation of ASD. But they are certainly not the root cause(s).

What people here are missing is ASD is a natural part of humanity and has always been with us. Loose correlations treating it as a "disease" are wrong. One day our thinking will change from the ableist "what is causing this and how can we fix it" to modern ideas of accepting autistic people as just regular people and giving accommodations as needed. We are not going away, ever. There's no "Fix" to this the same way there's and should not be a fix to being LGBTQ.

Re: Infant microbes and metabolites point to childhood neurodevelopmental disorders

#82

Post by matthest » Mon, Apr 08, 2024, 8:41 PM UTC

M0x20M wrote: post #68

matthest wrote: post #35

"Exercise appears to be effective in modifying the gut microbiota in both clinical and healthy populations." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054511/ Anecdotal: my persistent digestion issues completely disappeared when I started walking (not running, not jogging - walking) 2-3 miles a day.

I was involved in this field some years ago now, in one of the first randomized trials that assessed gut microbiome changes as response to aerobic exercise (with a very small effect size). Back then i felt all the evidence for exercise changing the microbiome was quite weak. At the time most of the evidence was observational or mice running on treadmills with very little actual randomised human evidence. The ones tha…

I'll defer to your expertise on studies. And I acknowledge that may be possible.

That said, anecdotally the difference is night and day. So whether it's actually altering the microbiome or altering some other mechanism, I try to recommend it as much as possible.

Re: Infant microbes and metabolites point to childhood neurodevelopmental disorders

#83

Post by M0x20M » Tue, Apr 09, 2024, 6:43 AM UTC

matthest wrote: post #82

M0x20M wrote: post #68

Earlier quoted context omitted.

I was involved in this field some years ago now, in one of the first randomized trials that assessed gut microbiome changes as response to aerobic exercise (with a very small effect size). Back then i felt all the evidence for exercise changing the microbiome was quite weak. At the time most of the evidence was observational or mice running on treadmills with very little actual randomised human evidence. The ones tha…

I'll defer to your expertise on studies. And I acknowledge that may be possible. That said, anecdotally the difference is night and day. So whether it's actually altering the microbiome or altering some other mechanism, I try to recommend it as much as possible.

Walking and zone 2 running are both amazing!

Re: Infant microbes and metabolites point to childhood neurodevelopmental disorders

#84

Post by pfisch » Mon, Apr 15, 2024, 4:09 AM UTC

NotGMan wrote: post #78

pfisch wrote: post #27

Earlier quoted context omitted.

> I've found this difficult as well, my mother always jumped right to antibiotics and it had some pretty clear long term consequences. How could this possibly be true that there were clear long term consequences? How could you reasonably know if there were long term consequences from antibiotic use? Which antibiotics cause what and how do you know they are the cause?

How do you know it wasn't the antibiotics? You can find many people online whose health (gut most often) got destroyed after a round of antibiotics. You obviously won't see this in studies, look for individuals: many such cases.

Why wouldn't we see this in studies if it was common?