Live data from Hacker News

Prostate cancer cases worldwide likely to double by 2040, analysis finds

theguardian.com

11–20 of 62 posts

Re: Prostate cancer cases worldwide likely to double by 2040, analysis finds

#11
post #5

“The number of men diagnosed with prostate cancer worldwide is projected to double to 2.9 million a year by 2040, with annual deaths predicted to rise by 85%, (…) and the most common form of male cancer in more than 100 countries. “ Iirc, some ethnicities have a higher risk rate and the risk increases with testosterone supplementation. One of the lines of defense is attempting to block T after mid stage diagnosis.

My understanding is that the alleged link between testosterone replacement therapy and prostate cancer has very weak evidence: https://www.health.harvard.edu/mens-health/appropriate-use-o... .

Thanks for the link and the 3yr study highlighting is a nice touch. Can’t edit my post though. I wonder if the blocking T is contraindicated also then. Sample size 1, a relative, it didn’t work at all to reduce testosterone.

“The study was limited to men with hypogonadism who had a low risk of prostate cancer, so it's not clear how TRT may affect higher-risk men or those who use testosterone in higher amounts, for longer periods of time, or for treating other conditions.”

Re: Prostate cancer cases worldwide likely to double by 2040, analysis finds

#12

You die with prostate cancer, not from it. It has a 95% survival rate.

I wouldn’t be thrilled to fly in a plane if it had a 5% chance to kill me.

You should multiply this 5% with the probability you have prostate cancer.

Re: Prostate cancer cases worldwide likely to double by 2040, analysis finds

#14

You die with prostate cancer, not from it. It has a 95% survival rate.

Let's say you undergo medical procedures to cure it, (chemo, surgery, etc.) and end up dying from a complication from it. Does that still count as a prostate cancer death (the 5%)?

Re: Prostate cancer cases worldwide likely to double by 2040, analysis finds

#15

You die with prostate cancer, not from it. It has a 95% survival rate.

About 40 years ago my father, an oncologist, told me there were two common types of prostate cancer, the fast growing type that kills you and the slow growing type that doesn't. We've learned a lot about it since then, but that description is still essentially true.

It causes 30,000 deaths a year in the US, which is not insignificant - in comparison breast cancer kills 40,000.

Re: Prostate cancer cases worldwide likely to double by 2040, analysis finds

#16
post #8

what are the symptoms? i have BPH and its been a struggle. I been taking zinc, saw palmetto but its only temporary. maybe i need to experience anal sex to fix this problem

Have you tried Tamsulosin (Flomax)? It seems to help a lot of the symptoms.

Re: Prostate cancer cases worldwide likely to double by 2040, analysis finds

#18
post #8

what are the symptoms? i have BPH and its been a struggle. I been taking zinc, saw palmetto but its only temporary. maybe i need to experience anal sex to fix this problem

Not to be crass but “sounding” would be most likely to provide urinary relief as this widens the urethra within the prostate gland. This is absolutely not medical advice, just a follow-on to your quip.

Re: Prostate cancer cases worldwide likely to double by 2040, analysis finds

#19
Prostate cancer survivor here, AMA.

Tips:

* I recommend everyone with a prostate get their PSA tested by age 45, or earlier if it runs in the family. It's a simple blood test but sometimes you have to ask for it.

* Early detection is key. A biopsy can assess how aggressive it is (the Gleason score). They can even genetically profile the tumor to further gauge risk (the Decipher score).

* Most cases are slow growing and may never escape the prostate. These are usually treated by simply monitoring them with more PSA testing, imaging and the occasional biopsy. Years ago these cases uses to be over-treated but now they have high quality data showing the safety of monitoring.

* If it hasn't left the prostate (stage 1 or 2) and they think you need treatment there are a few options. In lesser cases you can do focal therapy which is like zapping a small tumor. But it tends to be a multi-focal disease, so often you'll end up getting "definitive treatment": removing the prostate surgically or saturating it with radiation.

* Surgery typically uses a cool-ass remote-controlled robot called "the DaVinci" that operates through a set of small incisions.

* Radiation is done either via external beam -- you just lie there and get zapped -- or by inserting radioactive seeds directly into the prostate (brachytherapy).

* The main side effect of surgery is erectile dysfunction, because the nerves that control that run right along the prostate and nerves do not like getting manipulated. Recovery can take up to two years and you don't always get all your function back. I think that stat is something like 1/3rd get back to baseline, 1/3rd get there but with the help of meds (Viagra), and 1/3rd suffer permanent decline / need other interventions. There is also some incontinence but that typically resolves within weeks/months.

* Radiation also causes ED, as well as urinary bother and potentially some other issues. But these typically kick in later, possibly years later. There are also some short term side effects while undergoing treatment. It's a good option for older patients for sure but "younger" patients (* If it escapes the prostate (stage 3 or 4) then there is an awesome new scan called a PSMA PET that can locate where it is with radiomarkers. They might do focal treatment on hot spots, but the main course of treatment is hormone therapy.

* Hormone therapy is essentially chemical castration. It removes all the testosterone from your body, and this weakens prostate cancer cells. By all accounts it is not fun: kills libido, saps energy levels. But it's also not as rough as chemotherapy, so we're "lucky" prostate cells work that way. There has been a lot of development here; often when you hear there's a new prostate cancer drug it's for hormone therapy.

* We all die but you don't want to die from prostate cancer. It's typically drawn out and painful. I watched my dad go through it, and it's why I got tested early. Fortunately it is very treatable if caught early.

Re: Prostate cancer cases worldwide likely to double by 2040, analysis finds

#20
post #19

Prostate cancer survivor here, AMA. Tips: * I recommend everyone with a prostate get their PSA tested by age 45, or earlier if it runs in the family. It's a simple blood test but sometimes you have to ask for it. * Early detection is key. A biopsy can assess how aggressive it is (the Gleason score). They can even genetically profile the tumor to further gauge risk (the Decipher score). * Most cases are slow growing a…

While you're at it, schedule a colonoscopy too. Early detection saves lives.
Post reply on HN