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Scientists traced a mysterious Covid case back to six toilets

technologyreview.com

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Re: Scientists traced a mysterious Covid case back to six toilets

#41

I must be missing something. There was only one line back to the restroom? Shouldn't there be another trail back to their residence? Or is there a person who only poops at work?

They could live outside the city where they would be connected to a local septic system instead of a central city sewer.

Re: Scientists traced a mysterious Covid case back to six toilets

#42
post #41

I must be missing something. There was only one line back to the restroom? Shouldn't there be another trail back to their residence? Or is there a person who only poops at work?

They could live outside the city where they would be connected to a local septic system instead of a central city sewer.

That's a good point! I knew there was an edge case I was missing

Re: Scientists traced a mysterious Covid case back to six toilets

#43
post #25

Earlier quoted context omitted.

> Covid is supposedly a respiratory tract infection, so who'd be expecting it to only show up in the gut? That's the thing with SARS-CoV-2. It's primarily transmitted by aerosols, but it has also been shown to be transmitted via smearing. It's primarily a respiratory tract infection, but it has also been shown to have intestinal, cardiovascular and neurological impact as well as persistence in these tissues [1]. And…

> long covid Sadly the politicians are trying to wave that one away as well...

[flagged]

Re: Scientists traced a mysterious Covid case back to six toilets

#44

Earlier quoted context omitted.

> Covid is supposedly a respiratory tract infection, so who'd be expecting it to only show up in the gut? That's the thing with SARS-CoV-2. It's primarily transmitted by aerosols, but it has also been shown to be transmitted via smearing. It's primarily a respiratory tract infection, but it has also been shown to have intestinal, cardiovascular and neurological impact as well as persistence in these tissues [1]. And…

7 million people is 0.1% of the population. Approximately 1% of the population die per year. You think that's a big number, but it's not. People die.

But we do a lot to prevent that number from being higher.

Re: Scientists traced a mysterious Covid case back to six toilets

#45
post #40

Earlier quoted context omitted.

From the second link: > COVID-19 is associated with clinically significant symptoms despite resolution of the acute infection (i.e., post-COVID-19 syndrome). Fatigue and cognitive impairment are amongst the most common and debilitating symptoms of post-COVID-19 syndrome.

That's comparing to no infection and doesn't answer their question.

Your comment doesn’t make any sense because how would the absence of an infection ever arrive at a debilitating outcome and thus be a point of comparison? The parent claimed COVID doesn’t cause debilitating outcomes. I provided evidence it does, including specific use of the exact term by medical researchers. When they couldn’t refute that, they made an ambiguous appeal to other infections to distract from being wrong, trying to shift attention from their original, unsupported claim to a new claim (COVID is the same as other viruses), and demanding that I provide evidence contrary to that. But that’s separate from the truth or falsity of the original claim, and thus irrelevant.

Re: Scientists traced a mysterious Covid case back to six toilets

#46

I'm honestly of the opinion that all of the ethical questions that arose during this search are fairly minuscule compared to the potential findings that could help us end this never-ending outbreak altogether. (At least by developing better targets for drugs like Paxlovid, if their hypothesis about GI tract replication turns out to be correct.) Of them all the potential to reveal that the patient X is hiding their HI…

> could help us end this never-ending outbreak altogether.

it has jumped to so many other species where it has established reservoirs that it'll never be gone.

this virus is going to be with the human race for at least the next hundred years.

it may very well spill back from other species into new pandemics (although those pandemics are likely to look more like the 2009 swine flu pandemic since everyone will have cross reactive T-cells).

there's nothing we do to stop this with any known or really plausibly imagined technology.

even if you could snap your fingers and wipe it out of the human race, then the problem is that the longer it goes with humans not establishing immunity to it, the worse the pandemic will be when it jumps back from the deer or mice or whatever (although that likely wouldn't take very long at all).

Re: Scientists traced a mysterious Covid case back to six toilets

#47
post #29

Earlier quoted context omitted.

> There is nothing that can help us "end" the SARS-CoV-2 (COVID-19) outbreak. We could massively mitigate its effects to the point we could actually live with the virus without risking the often debilitating effects it can have. On a societal/systemic level: HEPA air filters in hospitals, care homes, public transport, schools, churches, generally any indoors place where large amounts of people gather would not just d…

It seems clear at this point that Covid (the latest variants in the wild, at any rate) does not cause "often debilitating effects", and so any mitigation must have its costs, which are very high for any easily-transmissible respiratory illness, weighed against its benefits, which are pretty low. Remember: "there are no solutions, only tradeoffs." Otherwise, we should just plug everyone into VR pods a la The Matrix an…

> It seems clear at this point that Covid (the latest variants in the wild, at any rate) does not cause "often debilitating effects"

Depending on the study, you have up to 45% of people experiencing covid symptoms (aka Long Covid) almost four months past infection, and around 10% that experience symptoms 18 months past infection [1].

The amount of people so massively impacted by Long Covid that they can't work any more or have to significantly reduce their labor hours is so large that it's been theorized to be a significant contributor to current labor shortages [2]. So yes, it does classify as "often" IMHO.

> and so any mitigation must have its costs, which are very high for any easily-transmissible respiratory illness, weighed against its benefits, which are pretty low.

Just the 2023/24 covid+rsv+influenza wave is suspected to have cost the German economy alone 36 billion euros in lost income and sick day payments [3].

We need pathogen mitigation concepts, the sooner the better.

[1] https://www.nature.com/articles/s41467-023-43661-w

[2] https://www.brookings.edu/articles/is-long-covid-worsening-t...

[3] https://www.deutschlandfunk.de/ifw-grippewelle-koennte-die-d...

Re: Scientists traced a mysterious Covid case back to six toilets

#48

Earlier quoted context omitted.

> Covid is supposedly a respiratory tract infection, so who'd be expecting it to only show up in the gut? That's the thing with SARS-CoV-2. It's primarily transmitted by aerosols, but it has also been shown to be transmitted via smearing. It's primarily a respiratory tract infection, but it has also been shown to have intestinal, cardiovascular and neurological impact as well as persistence in these tissues [1]. And…

7 million people is 0.1% of the population. Approximately 1% of the population die per year. You think that's a big number, but it's not. People die.

> You think that's a big number, but it's not.

Yeah, but generally, your standard flu doesn't end the careers of about 6% of athletes who manage to catch it [1]. Covid is worse than the flu.

> People die.

Old people, yes. Young, healthy people in the midst of their careers? No. That's quite the misconception that has always stuck with covid, particularly as politicians focused on protecting primarily the elderly - the reality is, of all the US covid deaths, a quarter were people below pension age [2].

[1] https://www.dw.com/en/https-wwwdwcom-en-life-with-long-covid...

[2] https://www.statista.com/statistics/1191568/reported-deaths-...

Re: Scientists traced a mysterious Covid case back to six toilets

#49

I'm honestly of the opinion that all of the ethical questions that arose during this search are fairly minuscule compared to the potential findings that could help us end this never-ending outbreak altogether. (At least by developing better targets for drugs like Paxlovid, if their hypothesis about GI tract replication turns out to be correct.) Of them all the potential to reveal that the patient X is hiding their HI…

> could help us end this never-ending outbreak altogether. it has jumped to so many other species where it has established reservoirs that it'll never be gone. this virus is going to be with the human race for at least the next hundred years. it may very well spill back from other species into new pandemics (although those pandemics are likely to look more like the 2009 swine flu pandemic since everyone will have cro…

my point was not to make it disappear, but to develop better targets for antivirals, which effectively make it end by just shortening the disease course to 1-2 days. Right now, the rebounds that happen are mostly due to virus reservoirs within the body that aren't completely eradicated by 5 day course. More effective targeting within the body could be key. Either way, saying "nothing can be done" and just throwing in the towel when valuable info could be obtained is not the way to go. Personally, I have a general interest in the virus (though I'd never work as a virologist due to my germaphobia) so I think it's worth investigating for its own sake.

Re: Scientists traced a mysterious Covid case back to six toilets

#50
post #29

Earlier quoted context omitted.

> There is nothing that can help us "end" the SARS-CoV-2 (COVID-19) outbreak. We could massively mitigate its effects to the point we could actually live with the virus without risking the often debilitating effects it can have. On a societal/systemic level: HEPA air filters in hospitals, care homes, public transport, schools, churches, generally any indoors place where large amounts of people gather would not just d…

It seems clear at this point that Covid (the latest variants in the wild, at any rate) does not cause "often debilitating effects", and so any mitigation must have its costs, which are very high for any easily-transmissible respiratory illness, weighed against its benefits, which are pretty low. Remember: "there are no solutions, only tradeoffs." Otherwise, we should just plug everyone into VR pods a la The Matrix an…

i think applying software engineering logic to diseases is fallacious. anyway, the reason you can say that is because there is basically no one left who doesn't have some sort of immunity against the virus. no immunologically naive people means better outcomes.
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