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Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

medicalxpress.com

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Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#191

Post by ggm »

cassepipe wrote: post #171
ggm wrote: post #102

Earlier quoted context omitted.

Because of homeostasis: dissolved substances like fats in the bloodstream are regulated within bands, and beyond certain limits the amount ingested doesn't translate to more: it's excreted or winds up elsewhere. Your metabolism may cause states worse than other people, sure. But that pound of butter you ingested isn't directly causing rises in the bloodstream to infinity. It's long-term accumulated burden and excess…

While I always knew that sugars where the main culprit for body fat thanks to a highschool biology class, I have never understood why fat is less of a problem so thank you. Could you link me with sources or search keyword in order to know more of what the body is doing with excess fat ?

I tried "what does the body do with excess fat" and I think it covers it. For sure, you get higher triglycerides floating around in the bloodstream, and the liver is under stress. at the extreme end, its Steatorrhea which is .. unpleasant (olestra goes to the same place)

The lymphatic system is also involved.

So it's not entirely "eat as much fat as you like" by any stretch. It's more that over time, the body tends back to a baseline model. Continual high levels of fat which cause surplus in the bloodstream are heading to arterial blockage and isn't good, but the relationship of fat ingested to fats in the blood is a more complex path. "it depends"

I'm not a bio scientist or a med. Happy to be corrected.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#192

Post by thelittleone »

cies wrote: post #147
imtringued wrote: post #142

Earlier quoted context omitted.

>You are a guinea pig when you do this long term. As opposed to being reliably obese? What's your baseline? I recently checked the average weight of men and women and I am honestly shocked.

Short term you can lose weight with ketosis. Long term you are taking unknown risks. The risks of obesity are well known. Also, you do not get obese by lack of a keto diet. One usually gets there with a rubbish diet.

For me I went keto because I had a problem with sugar addiction going back since childhood. I managed to maintain a healthy weight through exercise etc but as I aged I felt that my bodies ability to handle sugar was decreasing, and it had significant impact on my energy levels, physical appearance and digestion.

Keto not only simplified my diet but massively improved my digestion, and helped me form more awareness of risks of sugar.

Regarding no long term studies.. its hard to believe much these days I rely on body feedback. Years ago the American diet was supposed to be healthy, look how that science turned out.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#193

Post by cies »

Attummm wrote: post #151
cies wrote: post #114

Earlier quoted context omitted.

Humans are bad at lipogenesis: we can only convert tiny fraction of the carbs into fat. Thus: the fat your eat is largely the fat you wear. You cannot explain it otherwise (without showing a undiscoverd way humans can convert carbs into fat). > i.e. if you just fed someone large amounts of protein and fat they would be lean; it is the sugar and carbs that make them fat. This is dangerous. It may work on the short ter…

Why would a mammal's body evolved to use fat cells to store and utilise lipids for energy? Plants have carbs in starch. Mammals evolved away from starch to store and use triglycerides. During fasting, the human body is able to survive for months without food. Thus months of lipid metabolism

> Why would a mammal's body evolved to use fat cells to store and utilise lipids for energy?

Hibernation?

For short term glucose storage is preferred by mammals bodies that i know of.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#194

Post by cies »

thelittleone wrote: post #192
cies wrote: post #147

Earlier quoted context omitted.

Short term you can lose weight with ketosis. Long term you are taking unknown risks. The risks of obesity are well known. Also, you do not get obese by lack of a keto diet. One usually gets there with a rubbish diet.

For me I went keto because I had a problem with sugar addiction going back since childhood. I managed to maintain a healthy weight through exercise etc but as I aged I felt that my bodies ability to handle sugar was decreasing, and it had significant impact on my energy levels, physical appearance and digestion. Keto not only simplified my diet but massively improved my digestion, and helped me form more awareness of…

I'm glad it works for you. I'm not keto hating, I just find people advising to do it long term to be on the quacky side (there simply is no such evidence).

> Years ago the American diet was supposed to be healthy

The result of lobbying. True nutrition experts knew all along.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#195

Post by cies »

amanaplanacanal wrote: post #181
cies wrote: post #129

Earlier quoted context omitted.

It's not a modern disease, it simply has exploded in occurrence. This explosion is modern. This is likely due to our diet. There's a book called "the blue zones" that dives into healthy diets and lifestyles that have historically helped people grow old. > Food of yesteryear wasn't really better/healthier than now. Not all food was. But Okinawans do pretty well for a long, long time.

I’m not so convinced about “blue zones”. A lot of longevity claims seem to disappear once modern record keeping and birth certificates come into play.

Not aware of this. Any source you have?

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#196

Post by michaelcampbell »

amelius wrote: post #135
ProjectArcturis wrote: post #21

As a former Alzheimer's researcher, this is a big fucking deal. It puts together a lot of clues (APOE risk, microglia) and finds a theory that makes a lot of sense. All around the world, there are labs pulling late nights trying to figure out how to drug this.

Perhaps a stupid question but why wasn't this found earlier after examination of brain tissue?

I'm not an expert, but I've been reading lately that the plaque vector has been so well studied because it's the only direction that has been able to get funding. Conspiracy aside, this seems like a more common thing now - someone has a little bit of possible progress, and no one will give any money to any other thing, often at our detriment.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#197

Post by ffgjgf1 »

ineedaj0b wrote: post #137
ffgjgf1 wrote: post #88

Earlier quoted context omitted.

> Why did he have a job hosting fear factor. A job hosting UFC That has no relationship with someone being able to have meaningful discussions on complex topics. Probably even the opposite..

You don’t get a job in front of camera unless you’re good looking or talented. Rogan was not good looking.

He’s certainly talented. However again that has almost bo relationship to being able to have meaningful discussions on highly complex topics.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#198

Post by amanaplanacanal »

cies wrote: post #195
amanaplanacanal wrote: post #181

Earlier quoted context omitted.

I’m not so convinced about “blue zones”. A lot of longevity claims seem to disappear once modern record keeping and birth certificates come into play.

Not aware of this. Any source you have?

Not sure where I originally heard this, but I just found this preprint: https://www.biorxiv.org/content/10.1101/704080v3

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#199

Post by _heimdall »

simonbarker87 wrote: post #169
_heimdall wrote: post #152

Earlier quoted context omitted.

The calorie hypothesis isn't the most likely from all the research I've done. The calorie as a unit of measure doesn't even make much sense IMO. A calorie is measured by burning food a specific distance away from a specific amount of water and measuring how much the water temperature rises. It's based on an assumption that the body uses all energy in the food the same, and that fire is analogous to the complex proces…

Which the body basically is. Anyone who tracks their calories daily for a long period of time will see that when they eat more they gain weight, when they eat less they loose weight. Like I said above, there are other aspects that can factor but “calories in calories out” accounts for 80% of weight loss and weight gain (applying the broad brush of the 80:20 rule)

If a calorie is a calorie, would you agree that I would be just as well of eating 1800 calories of fat rather than a balanced diet? Could I stick to 1800 calories of gasoline?

We can't simply burn food and deem that an accurate analog to how the body processes and utilizes different food. Ask anyone that live(d) primarily on rabbit meat.

And to be clear, the 80:20 rule is am extremely broad and inaccurate rule of thumb that isn't useful when applied to something specific. You can't claim that calories in equals 80% of calories out because Paredo.

Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests

#200

Post by _heimdall »

antiframe wrote: post #173
_heimdall wrote: post #150

Earlier quoted context omitted.

We've probably done more harm with the similar, and also incorrect, assumption that eating more saturated fats go directly to the blood and clog arteries.

Can you point to some evidence that increased saturated fat consumption does not increase LDL? Or that there is no link between serum LDL levels and plaque build up? Or are you making a different claim?

Dr Michael Eades is a good gateway toif you're interested. He wrote a book a while ago now titled Protein Power [1], I think he is working on an update/sequel as well.

At the high level, my basic claim is that the idea that dietary saturated fat directly leads to heart attack is incorrect. The history of this claim dates back to President Eisenhower. After having a heart attack while in office he wanted to tell the public how he could avoid the same fate. Researchers cut corners to meet political targets, ignoring data that disproved their hypothesis and claimed that plaque found in cadaver arteries was made of saturated fats and that it got there due to the person's diet.

The claims weren't backed up by the studies used and we were told that this was now a known fact when it wasn't. We've spent many decades since avoiding saturated fats in favor of unsaturated fats, which are highly oxidative and have concerning side effects when run through the Krebs Cycle.

Dr Eades also has a few interesting talks on the subject when he walks through the Krebs Cycle and the difference of saturated and unsaturated fats in case that's helpful. I think [2] is one I watch years ago, though he has other similar talks on YouTube as well.

[1] https://proteinpower.com/ [2] https://www.youtube.com/watch?v=7MTNJNAZPiw

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