My aunt started showing symptoms of Alzheimer's. My grandfather passed from it. Is there any thing to do in order to prevent or delay the disease?
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Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
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Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#62Earlier quoted context omitted.
There is a weird crowd of people on the internet that have convinced themselves that seed oils are the cause of many ailments. It doesn’t have a ton of scientific backing but Joe Rogan promoted some guru doctor a while back that spread the idea to a lot more people.
>Joe Rogan promoted You mean he did an episode where he had a conversation with the doctor? Or was the doctor a sponsor of the show where he advertised products? I don't think simply having a conversation about an idea counts as promotion. Advertising is another matter though..
Having a conversation in a very public place can certainly end up promoting ideas
Take a popular piece of media, inject a conversation about fringe ideas with some crackpot that would have very limited reach otherwise. This gives very high visibility to very fringe ideas.
Giving undue weight to fringe viewpoints is promoting those viewpoints.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#63So, is this why fasting sometimes seems like a solution? Edit: Oversimplified, but: Less, calories, less fat? Excess calories, more fat?
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Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#64So, is this why fasting sometimes seems like a solution? Edit: Oversimplified, but: Less, calories, less fat? Excess calories, more fat?
In addition to weight loss, fasting can reduce activated microglia in the brain which could play some part in this, as microglia was mentioned in the study.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#65Earlier quoted context omitted.
>Joe Rogan promoted You mean he did an episode where he had a conversation with the doctor? Or was the doctor a sponsor of the show where he advertised products? I don't think simply having a conversation about an idea counts as promotion. Advertising is another matter though..
Having a conversation in a very public place can certainly end up promoting ideas Take a popular piece of media, inject a conversation about fringe ideas with some crackpot that would have very limited reach otherwise. This gives very high visibility to very fringe ideas. Giving undue weight to fringe viewpoints is promoting those viewpoints.
Promotion: "activity that supports or provides active encouragement for the furtherance of a cause"
Simply discussing an idea, even giving undue weight, is not promotion.
Conflating the two is dangerous as it provides justification for censorship. The free exchange of ideas and information is the only way a democracy can survive.
If the idea is bad or wrong, it will be debated and ultimately defeated in the marketplace of ideas.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#66Doesn't this boost the hypothesis that Alzheimer's is closely related to insulin resistance in the brain? What some people call type III diabetes. I ask because one of the hallmarks of insulin resistance is the presence of lipid droplets in close proximity to mitochondria [0]. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10455923/
If it does boost that hypothesis, what then? Are there things you can do aside from the basic focus on diet, exercise, and sleep?
If this proves out we focus on finding the precise mechanism and how to disrupt it.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#67Earlier quoted context omitted.
A stopped clock is right twice a day. A broken clock could potentially never be right, like if it's perpetually 10 minutes behind.
That's not a broken clock, that's a clock that's set to the wrong time. Unless it remains 10 minutes behind, even when you set it 10 minutes forward, which would be a great prank gift.
A broken analogy never stops.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#68Earlier quoted context omitted.
If I am rich enough to have a down payment for a Bay Area house I’ll be tremendously in debt. But that wouldn’t put me in the same boat as someone with oodles of credit card debt. I’m guessing in endurance athletes it’s there because it’s about to be used. In the obese it’s there because they’re running out of places to put fat.
Right - but even then, if a super fit endurance athlete stops exercising, they don't immediately become diabetic. The upstream cause (what biochemical stimulus is driving the fat deposition?) is probably where the key insight lies.
If I recall correctly there were some studies that actually showed endurance runners have higher type 2 diabetes risk. And the suspect cause was the diet, specifically the carb loading practice and the abuse of high sugar products during the activity. So the three categories may actually share the same baseline, insulin resistance. It was quite controversial when it emerged (see Tim Noakes story), not sure if it's more accepted these days.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#69Earlier quoted context omitted.
There is a weird crowd of people on the internet that have convinced themselves that seed oils are the cause of many ailments. It doesn’t have a ton of scientific backing but Joe Rogan promoted some guru doctor a while back that spread the idea to a lot more people.
>Joe Rogan promoted You mean he did an episode where he had a conversation with the doctor? Or was the doctor a sponsor of the show where he advertised products? I don't think simply having a conversation about an idea counts as promotion. Advertising is another matter though..
When you have a massive megaphone, your choices have impact at scale.
So "having a conversation" is functionally identical to promoting, as is "just asking questions" if you're Tucker Carlson, or "exercising your free speech" if you're Elon Musk amplifying easily disproven talking points about immigration, etc.
Noblesse oblige.
Re: Root cause of Alzheimer's may be fat buildup in brain cells, research suggests
#70My aunt started showing symptoms of Alzheimer's. My grandfather passed from it. Is there any thing to do in order to prevent or delay the disease?
Vaccines. Many of them, seemingly unrelated. Not to delay, but to prevent. I wonder how that links in with this finding.