I'm not a compiler engineer, but I think it's a diminishing returns issue. Modern optimising compilers are already impressive, and they get more impressive year on year, but only quite slowly. We don't see compilers producing code that runs 30% faster than the code generated last year, for instance.
Such improvements can happen with compiler updates, but not when the starting point is a compiler that's already of decent quality. I recall some GPU driver updates from ATi (years ago) delivered pretty drastic performance improvements, but I believe that's because the original drivers were rather primitive.
(Perhaps a drastic improvement to autovectorisation could give a 30% boost, or better, but this would apply only to certain programs.)
You could grant a compute budget 100x the typical build set-up, but no one has built a production-ready compiler to take advantage of that, and if they did I suspect the improvements would be unimpressive. They may also run into a 'complexity ceiling' issue, as the compiler would presumably be even more complex than today's ordinary optimising compilers, which are already enormous.
As Filligree says, superoptimisers tend to only be practical for very short programs. They can't be applied to monstrous codebases like Chromium.