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Story of Vitamin D Toxicity (2022)

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Re: Story of Vitamin D Toxicity (2022)

#51

Post by 0xbadcafebee »

Traubenfuchs wrote: post #32
llmblockchain wrote: post #15

I read a study today about a person that got a blood infection from the "good" bacteria in yogurt, and died. Nature be scary yo. If you can be taken out by yogurt I imagine anything can do it used in the wrong way, or even the correct way on occasion.

Salad considered harmful. https://archive.is/wip/vqmi5 > Professor Pennington also pointed out that a bean sprout farm in northern Germany was identified as the most likely source of many of the infections in the E. coli outbreak that left 22 people dead in 2011.

On the CDC's website there seems to be an outbreak of e. coli every year, and uncooked greens are a constant: https://www.cdc.gov/ecoli/outbreaks.html

Washing them doesn't help: https://www.consumerreports.org/e-coli/washing-greens-protec...

Could be linked to cows: https://www.theguardian.com/environment/2020/sep/01/unclean-... https://www.verywellhealth.com/lettuce-e-coli-contamination-...

On top of all that, root veggies and leafy greens absorb a lot of toxins: https://www.canr.msu.edu/news/vegetable_selection_makes_a_di... https://pubmed.ncbi.nlm.nih.gov/15016510/

Re: Story of Vitamin D Toxicity (2022)

#52

Post by mchinen »

hombre_fatal wrote: post #28
hammock wrote: post #19

Earlier quoted context omitted.

The widely used daily recommended amounts of Vitamin D (600 IU in the US and Canada) are wrong, by a factor of 10, and based on a math typo that no one caught until 2017: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541280/ . I guess many still don't realize this fact. "We call public health authorities to consider designating as the RDA ... around 8000 IU for adults"

Can you corroborate their opinion with other sources? It’s not very evidence based.

https://vitamindforall.org/letter.html is a letter that goes into why >= 4000 IU daily is recommended based on blood serum levels with more literature review.

Re: Story of Vitamin D Toxicity (2022)

#53

Post by lambdaba »

Novosell wrote: post #43
lambdaba wrote: post #36

Earlier quoted context omitted.

> The knowledge about toxicity from hypervitaminosis D in terms of dosage and duration is limited. Because of the high heterogeneity in reported amounts of vitamin D intoxication cases, it is not possible to calculate a reliable mean value that will invariably induce toxic effects. The highest daily dose hitherto reported in the literature is about 2,000,000 UI/day that has led to intoxication in a couple of months >…

Quotes without a source? > 1mg will instantly kill you.

does not jive with the documented case of 2M IU (50mg) per day for months, nor with this case:

> Two patients, a Caucasian 90-year old man and a 95-year old woman, were monitored from 1 h up to 3 months after intake for clinical as well as biochemical signs of vitamin D intoxication. Blood vitamin D3 concentrations showed a prompt increase with the highest peak area already hours after the dose, followed by a rapid decrease to undetectable levels after day 14. Peak blood 25(OH)D3 concentrations were observed 8 days after intake (527 and 422 nmol/L, respectively (ref: 50–200 nmol/L)). Remarkably, plasma calcium levels increased only slightly up to 2.68 and 2.73 mmol/L, respectively (ref: 2.20–2.65 mmol/L) between 1 and 14 days after intake, whereas phosphate and creatinine levels remained within the reference range. No adverse clinical symptoms were noted.

Re: Story of Vitamin D Toxicity (2022)

#54

Post by mixmastamyk »

lambdaba wrote: post #29
JohnMakin wrote: post #4

I struggle to believe that a physician told her to take 5000 IU of vitamin D daily for 5+ years. This is nearly 10x canada's recommended winter time dose for adults under 70. After years of struggling with severe joint pain and mental fog/depression, among other things it was discovered that I had critically low vitamin D. They prescribed the 5000 dose but told me at least 10 times how I should NOT continue this high…

The fear of vitamin D overdose is GREATLY overblown, people recover even with overdose with ridiculous (2 MILLION) units over several weeks, anyway, it's strange how much fear has been manufactured over this particular "vitamin".

That was enough to prevent rickets and the goal in the old days. Perhaps why not revisited for a long time.

Re: Story of Vitamin D Toxicity (2022)

#55

Post by JohnMakin »

chimeracoder wrote: post #41
JohnMakin wrote: post #11

Earlier quoted context omitted.

Yea, the dosage and labeling for sure needs work. I see 2000 IU doses regularly sold in stores and the bottle says you can take 2/day. Obviously no doctor would recommend that for anyone not sick. I also get regular blood tests since, I'd guess most people using supplements do not.

> Yea, the dosage and labeling for sure needs work. I see 2000 IU doses regularly sold in stores and the bottle says you can take 2/day. Obviously no doctor would recommend that for anyone not sick. That is simply not true. Doctors do recommend 2000-4000 IU for healthy patients all the time.

I should clarify by what I obviously meant that doctors would not recommend that as a DAILY dose - daily implying long-term use is okay.

Re: Story of Vitamin D Toxicity (2022)

#56

Post by chasil »

Traubenfuchs wrote: post #32
llmblockchain wrote: post #15

I read a study today about a person that got a blood infection from the "good" bacteria in yogurt, and died. Nature be scary yo. If you can be taken out by yogurt I imagine anything can do it used in the wrong way, or even the correct way on occasion.

Salad considered harmful. https://archive.is/wip/vqmi5 > Professor Pennington also pointed out that a bean sprout farm in northern Germany was identified as the most likely source of many of the infections in the E. coli outbreak that left 22 people dead in 2011.

Bean sprouts are well known to be dangerous when eaten raw.

'Such infections, which are so frequent in the United States that investigators call them "sproutbreaks", may be a result of contaminated seeds or of unhygienic production with high microbial counts.'

https://en.wikipedia.org/wiki/Sprouting#Health_concerns

Re: Story of Vitamin D Toxicity (2022)

#57

Post by Novosell »

lambdaba wrote: post #53
Novosell wrote: post #43

Earlier quoted context omitted.

Quotes without a source? > 1mg will instantly kill you.

does not jive with the documented case of 2M IU (50mg) per day for months, nor with this case: > Two patients, a Caucasian 90-year old man and a 95-year old woman, were monitored from 1 h up to 3 months after intake for clinical as well as biochemical signs of vitamin D intoxication. Blood vitamin D3 concentrations showed a prompt increase with the highest peak area already hours after the dose, followed by a rapid d…

[flagged]

Re: Story of Vitamin D Toxicity (2022)

#58

Post by nh23423fefe »

0xbadcafebee wrote: post #39

> The only lingering effects appeared to be a wariness of physicians and distrust of vitamins, both understandable I am not a doctor, by any stretch of the imagination. But I do work on cars, and computers. As far as I can tell, a doctor works exactly the same way as a mechanic or a computer technician. They listen to symptoms, make an educated guess at a root cause based on limited information, make an educated gues…

seems like your entire argument hinges on misusing words the words: exactly, symptoms, art, science, and trust

Re: Story of Vitamin D Toxicity (2022)

#59

Post by bun_terminator »

lambdaba wrote: post #46
Novosell wrote: post #43

Earlier quoted context omitted.

Quotes without a source? > 1mg will instantly kill you.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8811610/ Figured people can Google, all I bring is awareness this is widely overblown, having taken myself, for therapeutic purposes, upwards of 100k IU per day for months without doctor supervision (but doing it correctly, with a very low calcium diet). People take vit D megadoses for autoimmunity, with significant success, but I'm not discussing this here.

Since you seem to be an expert: What about different forms of vit D? I vaguely remember discussions about pills not being absorbed well. Also I remember people talking that vit D intervention fails to do anything besides raising the blood levels, indicating that things might be more complex. I'm interested in the topic, but never really dived into it.

Re: Story of Vitamin D Toxicity (2022)

#60

Post by Balgair »

0xbadcafebee wrote: post #39

> The only lingering effects appeared to be a wariness of physicians and distrust of vitamins, both understandable I am not a doctor, by any stretch of the imagination. But I do work on cars, and computers. As far as I can tell, a doctor works exactly the same way as a mechanic or a computer technician. They listen to symptoms, make an educated guess at a root cause based on limited information, make an educated gues…

> They listen to symptoms, make an educated guess at a root cause based on limited information, make an educated guess at what might resolve the situation, and then wait to hear back if that fixed it; if it didn't, the loop continues.

Having been a mechanic and having worked with a lot of MDs, unfortunately, neither profession really works that way anymore.

Mostly, you're taking symptoms, yes, but then you use a computer system to 'help' educate your guesses. By 'help' here, I mean that most mechanics and MDs just kinda blindly plug the symptoms into the computer and then start reading.

These systems have pretty detailed stats on the possible causes and fixes, what you should go check out again to get more data for the computer, etc.

Both sets of systems can pretty reliably turn a C level person into a B+/A- level person. As such the subscriptions are worth every penny.

Mechanics (in my day) use AllData : https://www.alldata.com/us/en/repair

MDs use UpToDate : https://www.uptodate.com/login

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