This is the biggest thing for me, I would love to have a big fancy lab setup at home, but when you start adding up the power consumption and put a monthly dollar amount to it, then it becomes less exciting. Especially if you live somewhere like California where home electricity bills are incredibly high nowadays, it is extra painful.
There are some low-power setups that are great, but it seems like once you start using rack-mounted equipment, the machines get more power-hungry.