[dead]
Man in remission from blood cancer and HIV after remarkable treatment
51–60 of 61 posts
Re: Man in remission from blood cancer and HIV after remarkable treatment
#52Earlier quoted context omitted.
Are there still laws in place that prohibit research using stem cells? That might not help
Some highlights after reading the Wikipedia article on Stem cell controversy: - Austria, Denmark, France, Germany, Portugal and Ireland do not allow the production of embryonic stem cell lines - The creation of embryonic stem cell lines is permitted in Finland, Greece, the Netherlands, Sweden, and the United Kingdom - Arkansas, Indiana, Louisiana, North Dakota and South Dakota have passed laws to "prohibit the creati…
my understanding is that embryos aren't the primary source of stem cells anymore and all of these jurisdictions are satisfied
Miqu 70B Q4_K_M writes
Embryonic stem cells are one of the main sources, but not the only ones. Embryonic stem cells are derived from embryos that are 3-5 days old. These cells have the ability to develop into all cell types in the body. However, due to ethical concerns and the limited availability of human embryos, researchers have also developed methods to create induced pluripotent stem cells (iPSCs). iPSCs are adult cells that have been reprogrammed to behave like an embryonic stem cell. They can be generated directly from adult tissues, such as skin or blood cells. Another source of stem cells is the umbilical cord blood and tissue, which is rich in hematopoietic stem cells. Adult (or somatic) stem cells are also present in various tissues in our body, such as bone marrow and fat.
and here is a wiki and non-wiki source I found on iPSCs just in case the LLM made up an acronym. https://en.wikipedia.org/wiki/Induced_pluripotent_stem_cell
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347549/#:~:tex....
(this is how I do most of my queries these days)
Re: Man in remission from blood cancer and HIV after remarkable treatment
#53These sort of articles pop up every few months and make people hopeful for a cure, but this is sadly unlikely to ever be a viable one. Stem cell transplantation is a standard treatment for several blood cancers, but will almost certainly never be a standard HIV treatment for anyone except patients who need a transplantation anyway, for one single reason: with modern medicine, living with transplanted stem cells is si…
Not the same as large-scale transplantation, but that reminds me of some work in Chimeric Antigen Receptor (CAR) T-Cell therapy, where the dangerously-useful cells either have a manual suicide-switch or else another method to temporarily deactivate/reactivate them.
So still sci-fi at this point, but I'm imagining some kind of "bone marrow in a box" implant which cages the borrowed immune-system (copied, rather than genetically-engineered) within a barrier that somehow allows only roaming/non-reproducing cells to exit.
Re: Man in remission from blood cancer and HIV after remarkable treatment
#54Here's a dumb question: is it possible to culture stem cells? Or make more of them? Or does every stem cell have to be donated?
And another one: could we take someone's own stem cells, edit this mutation into them with CRISPR, culture more of them, and then re-implant them?
Yes, there are approved treatments that do exactly this with stem cells for some diseases.
Re: Man in remission from blood cancer and HIV after remarkable treatment
#55Re: Man in remission from blood cancer and HIV after remarkable treatment
#56Re: Man in remission from blood cancer and HIV after remarkable treatment
#57Re: Man in remission from blood cancer and HIV after remarkable treatment
#58Here's a dumb question: is it possible to culture stem cells? Or make more of them? Or does every stem cell have to be donated?
Also sounds like you could create a human clone embryo and harvest the stem cells.
There are already surrogate pregnancy outsourcing places in poor parts of the world - if this is viable I expect this to become the new blood boy fad for the rich.
Re: Man in remission from blood cancer and HIV after remarkable treatment
#59These sort of articles pop up every few months and make people hopeful for a cure, but this is sadly unlikely to ever be a viable one. Stem cell transplantation is a standard treatment for several blood cancers, but will almost certainly never be a standard HIV treatment for anyone except patients who need a transplantation anyway, for one single reason: with modern medicine, living with transplanted stem cells is si…
>but this is sadly unlikely to ever be a viable one.
I'm not a medical expert by any means, but you claiming this is unlikely to ever be a viable idea makes me think of the sheer number of things we take for granted today in medicine that to a 19th century or even an early 20th century doctor would seem flatly absurd, or completely incredible. A supposition of never makes a bet that one's own limited frame of knowledge, cognitive capacity and imagination has a leg up on all the potential decades ahead of us worth of new discoveries by a vast number of other very clever people. It' s a bet I wouldn't make in my own favor or anyone else's.
Re: Man in remission from blood cancer and HIV after remarkable treatment
#60Earlier quoted context omitted.
[flagged]
Isn't it better to actually consider their arguments than dismissing them for being just who they are? Many of these people are extremely skilled in philosophy and ethics Although their arguments often are based on religious grounds that you may dismiss, you may also find that similar principles can be derived from humanistic traditions alone.
They get dismissed because they are toxic people and there is no value in dealing with them. They kill kids and entrap people and break them so they can keep exploiting people. Its a system of exploitation. If you're under 8yo, you can believe in Santa, but once you're old enough, you shouldn't believe in imaginary friends that someone else made up, especially if those imaginary friends are psychopaths.