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Man in remission from blood cancer and HIV after remarkable treatment

theguardian.com

31–40 of 61 posts

Re: Man in remission from blood cancer and HIV after remarkable treatment

#31

Are these sorts of treatments available anywhere in Europe?

On our underfunded government socialized healthcare systems? No way. Those who are minted go to the US or Switzerland for best cutting edge treatments and prosthetics.

This procedure was first used about a decade ago in Germany.

Re: Man in remission from blood cancer and HIV after remarkable treatment

#32
post #2

Here's a dumb question: is it possible to culture stem cells? Or make more of them? Or does every stem cell have to be donated?

And another one: could we take someone's own stem cells, edit this mutation into them with CRISPR, culture more of them, and then re-implant them?

Yes in theory. However there is a lot of tricky parts that mean we are not doing this in real humans often it at all.

Re: Man in remission from blood cancer and HIV after remarkable treatment

#33
post #17

Are these sorts of treatments available anywhere in Europe?

I believe its a byproduct of stem cell transplant treatment for blood cancer combined with the luck that the matching donor having a mutation that protects against HIV.

It’s not “luck”. They specifically look for such a donor.

Re: Man in remission from blood cancer and HIV after remarkable treatment

#34

Earlier quoted context omitted.

Some highlights after reading the Wikipedia article on Stem cell controversy: - Austria, Denmark, France, Germany, Portugal and Ireland do not allow the production of embryonic stem cell lines - The creation of embryonic stem cell lines is permitted in Finland, Greece, the Netherlands, Sweden, and the United Kingdom - Arkansas, Indiana, Louisiana, North Dakota and South Dakota have passed laws to "prohibit the creati…

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As an atheist, I would say that the opinions of these organisations do matter, insofar as they are likely to influence political opinion in the countries where they have significant followers.

Re: Man in remission from blood cancer and HIV after remarkable treatment

#35
post #25

These sort of articles pop up every few months and make people hopeful for a cure, but this is sadly unlikely to ever be a viable one. Stem cell transplantation is a standard treatment for several blood cancers, but will almost certainly never be a standard HIV treatment for anyone except patients who need a transplantation anyway, for one single reason: with modern medicine, living with transplanted stem cells is si…

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Re: Man in remission from blood cancer and HIV after remarkable treatment

#36
post #25

These sort of articles pop up every few months and make people hopeful for a cure, but this is sadly unlikely to ever be a viable one. Stem cell transplantation is a standard treatment for several blood cancers, but will almost certainly never be a standard HIV treatment for anyone except patients who need a transplantation anyway, for one single reason: with modern medicine, living with transplanted stem cells is si…

This is correct. I have an extremely rare leukemia This is not something you're going to want for something as apparently treatable as HIV.

Re: Man in remission from blood cancer and HIV after remarkable treatment

#37
post #2

Here's a dumb question: is it possible to culture stem cells? Or make more of them? Or does every stem cell have to be donated?

Induced pluripotent stem cells (iPS) were a major development by Shinya Yamanaka around 20 years ago. Essentially, you take an adult's cell and induce it to become a stem cell.

I don't know much more about it but that certainly is part of the answer to your question. Hopefully others will chime in ...

Re: Man in remission from blood cancer and HIV after remarkable treatment

#38

Earlier quoted context omitted.

Some highlights after reading the Wikipedia article on Stem cell controversy: - Austria, Denmark, France, Germany, Portugal and Ireland do not allow the production of embryonic stem cell lines - The creation of embryonic stem cell lines is permitted in Finland, Greece, the Netherlands, Sweden, and the United Kingdom - Arkansas, Indiana, Louisiana, North Dakota and South Dakota have passed laws to "prohibit the creati…

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It matters to people who live in Muslim-majority countries.

Re: Man in remission from blood cancer and HIV after remarkable treatment

#39
post #18

Stem cells seem to have this potential to cure so many things but we are somehow not there yet.

Are there still laws in place that prohibit research using stem cells? That might not help

California legalized stem cell research ~20 years ago, https://www.nytimes.com/2002/09/23/us/california-law-permits... This led to CA being one of the world leaders (funny that a state can be a world leader, but that's CA in a nutshell) in stem cell research and applications.

I worked in a few labs that did stem cell work and we got really attached to some of them. Like, "here's a microbrain I've been growing for 3 months", you start to empathize with them a bit.

Re: Man in remission from blood cancer and HIV after remarkable treatment

#40
post #2

Here's a dumb question: is it possible to culture stem cells? Or make more of them? Or does every stem cell have to be donated?

And another one: could we take someone's own stem cells, edit this mutation into them with CRISPR, culture more of them, and then re-implant them?

Yes, example: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418799/ although I am not sure if T cells are considered stem cells or derived.
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